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{"id":556797886537,"title":"Victoza Review: Are Anti-Diabetic Injections Effective?","created_at":"2022-07-31T21:51:09-04:00","body_html":"\u003cscript type=\"application\/ld+json\"\u003e\/\/ \u003c![CDATA[\n{\n \"@context\": \"https:\/\/schema.org\",\n \"@type\": \"Article\",\n \"headline\": \"Victoza Review: Are Anti-Diabetic Injections Effective?\",\n \"keywords\": \"victoza, victoza review, victoza reviews, victoza side effects, victoza weight loss, victoza dosage, victoza insulin, saxenda vs victoza, ozempic vs victoza\",\n \"description\": \"Our research team reviews medical studies on Victoza to determine if it's effective for type-2 diabetes. We analyze whether the drug causes weight loss, highlight its side effects, and compare its efficacy to another popular injectable diabetes medication called Ozempic.\",\n \"url\": \"https:\/\/illuminatelabs.org\/blogs\/health\/victoza-review\",\n\"author\": {\n \"@type\": \"Person\",\n \"name\": \"Calloway Cook\",\n \"url\": \"https:\/\/illuminatelabs.org\/pages\/calloway-cook\",\n \"sameAs\": \"https:\/\/www.linkedin.com\/in\/calloway-cook\/\",\n \"jobTitle\": \"President\",\n \"knowsAbout\": \"entrepreneurship, dietary supplements, herbal supplements, eCommerce, medical research\",\n \"alumniOf\": {\n \"@type\": \"EducationalOrganization\",\n \"name\": \"S.I. Newhouse School of Public Communications at Syracuse University\"\n },\n \"memberOf\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n }\n},\n\"creator\": {\n \"@type\": \"Person\",\n \"name\": \"Calloway Cook\",\n \"url\": \"https:\/\/illuminatelabs.org\/pages\/calloway-cook\",\n \"sameAs\": \"https:\/\/www.linkedin.com\/in\/calloway-cook\/\",\n \"jobTitle\": \"President\",\n \"knowsAbout\": \"entrepreneurship, dietary supplements, herbal supplements, eCommerce, medical research\",\n \"alumniOf\": {\n \"@type\": \"EducationalOrganization\",\n \"name\": \"S.I. Newhouse School of Public Communications at Syracuse University\"\n },\n \"memberOf\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n }\n},\n\"editor\": {\n \"@type\": \"Person\",\n \"name\": \"Taylor Graber MD\",\n \"url\": \"https:\/\/illuminatelabs.org\/pages\/taylor-graber\",\n \"sameAs\": \"https:\/\/www.linkedin.com\/in\/taylor-j-graber-md-81351642\/\",\n \"jobTitle\": \"Content Partner\",\n \"knowsAbout\": \"medicine, health, anesthesiology, iv therapy, science, drugs, pharmaceutical, medical research, scientific research, medical journals, entrepreneurship, healthcare, orthopedic surgery, biomedical engineering\",\n \"alumniOf\": {\n \"@type\": \"EducationalOrganization\",\n \"name\": [\n \"University of California San Diego\",\n \"Arizona University\",\n \"University of Arizona College of Medicine\"\n ]\n },\n \"memberOf\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n }\n},\n\"image\": {\n\"@type\": \"ImageObject\",\n\"url\": \"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Victoza_Thumbnail.png?v=1659318895\",\n\"width\": \"3008\",\n\"height\": \"3008\"\n},\n\"citation\": [\n\"https:\/\/illuminatelabs.org\/blogs\/health\/saxenda-review\", \n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21609656\/\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21844879\/\",\n\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6981922\/\",\n\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8820228\/\",\n\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK551568\/\",\n\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8017323\/\",\n\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2017\/022341s027lbl.pdf\",\n\"https:\/\/www.victoza.com\/getting-started-on-victoza-\/your-first-injection.html\",\n\"https:\/\/www.drugs.com\/comments\/liraglutide\/victoza-for-diabetes-mellitus-type-ii.html\",\n\"https:\/\/illuminatelabs.org\/blogs\/health\/ozempic-review\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30122305\/\",\n\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8466858\/\"\n],\n\"mentions\": [{\n \"@type\": \"Thing\",\n \"name\": \"Saxenda\"\n },\n {\n \"@type\": \"Thing\",\n \"name\": \"type-2 diabetes\"\n },\n {\n \"@type\": \"Thing\",\n \"name\": \"FDA\"\n },\n {\n \"@type\": \"Thing\",\n \"name\": \"StatPearls\"\n },\n {\n \"@type\": \"Thing\",\n \"name\": \"Drugs.com\"\n },\n {\n \"@type\": \"Thing\",\n \"name\": \"liraglutide\"\n }\n],\n\"datePublished\": \"2022-07-31\",\n\"copyrightHolder\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n},\n\"publisher\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\",\n \"url\": \"https:\/\/illuminatelabs.org\/\",\n \"description\": \"Illuminate Labs is the most transparent supplement company in the U.S., and is a leading publisher of research-based health information.\",\n \"knowsAbout\": \"supplements, science, nutrition, exercise, health, medication, pharmaceutical, wellness, diet, weight loss, medical research\",\n \"publishingPrinciples\": \"https:\/\/illuminatelabs.org\/pages\/editorial-guidelines\",\n \"logo\": {\n \"@type\": \"ImageObject\",\n \"url\": \"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Illuminate_Labs_Logo.png?v=1641249064\", \n \"width\": 150,\n \"height\": 150\n},\n \"foundingDate\": \"2019-01-30\",\n \"Address\": {\n \"@type\": \"PostalAddress\",\n \"streetAddress\": \"50 Union Street, Unit 9\",\n \"addressLocality\": \"Northampton\",\n \"addressRegion\": \"Massachusetts\",\n \"postalCode\": \"01060\",\n \"addressCountry\": \"US\"\n},\n \"sameAs\": [\n \"https:\/\/www.instagram.com\/illuminatelabs\",\n \"https:\/\/twitter.com\/illuminatelabs\",\n \"https:\/\/www.linkedin.com\/company\/illuminate-labs-supplements\",\n \"https:\/\/www.youtube.com\/channel\/UCpgSJAsIPb-fZ25djtTxBEA\"\n ]\n }\n}\n\/\/ ]]\u003e\u003c\/script\u003e\n\u003cp\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Victoza_Review_Article_Header_Image_Optimized.png?v=1659318830\" alt=\"\"\u003e\u003c\/span\u003e\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eDisclaimer: None of the information in this article constitutes medical advice, and is just the opinion of the writer(s) and published for informational purposes only. We recommend that patients follow their doctor’s guidance in regard to prescription medication.\u003c\/span\u003e\u003c\/i\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan class=\"dc\"\u003eV\u003c\/span\u003eictoza is an injectable prescription medication for type-2 diabetes. The generic form of the drug is called liraglutide, and is also the active ingredient in a prescription weight loss medication called \u003c\/span\u003e\u003ca href=\"https:\/\/illuminatelabs.org\/blogs\/health\/saxenda-review\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSaxenda\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe’ll use the terms liraglutide and Victoza interchangeably throughout this article, as they refer to the same active drug ingredient.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIn this article we’ll review published medical studies on Victoza to determine if it’s effective for treating type-2 diabetes. We’ll highlight potential side effects of the medication, share research-based dosage information, and compare the drug to other diabetes medications such as Ozempic.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eIs Victoza Effective For Diabetes?\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eVictoza has been studied in many clinical trials for its effectiveness in treating type-2 diabetes.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOne \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21609656\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emedical review\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e published in the \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eHealth Technology Assessment\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e journal found that Victoza at both of its prescribed doses was effective for reducing blood glucose on average. The researchers noted that the drug also reduced systolic blood pressure which could be considered a potential secondary benefit for patients with high blood pressure and type-2 diabetes.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAnother \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21844879\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emeta-study\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e from 2020 examined whether Victoza could be a beneficial adjunctive treatment to insulin in patients with type-1 diabetes. This means that both medications were used concurrently. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAfter analyzing data from over 2,400 patients, the study authors found that Victoza reduced blood sugar levels compared to insulin alone. Those taking Victoza also required less daily insulin.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eA recent \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6981922\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emedical study\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e examined the long-term effectiveness of Victoza for diabetes, which was a useful inquiry because medical trials can often be short in duration. The researchers examined the efficacy of the drug over the course of 5 years.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eHemoglobin A1c (HbA1c) levels, which is a marker for blood sugar, decreased from an average starting point of 7.9 to 7 at the end of the trial. This represents a blood sugar decrease of 11.4%. The researchers also noted that fasting blood sugar levels experienced a “significant reduction.”\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe will conclude from the available research that Victoza is effective for managing diabetes. It is effective for treating type-2 diabetes, and potentially effective for treating type-1 diabetes, but the drug is only approved by the Food and Drug Administration (FDA) in the U.S. for treating type-2 diabetes because it has more research backing for that condition.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eIs Victoza Effective for Weight Loss?\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003ePatients are often curious about whether Victoza is effective for weight loss, given that the same active drug ingredient is FDA-approved for weight loss at a higher dose, in the form of the drug Saxenda.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOne of the previously-referenced studies, on the long-term outcomes of Victoza, reported on body weight changes. The study authors documented that average body weight in the overweight and obese trial population decreased from 92.1 kilograms (kg), which equates to 203 pounds (lbs) to 87.3 kg, which equates to 192.5 lbs.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThis isn’t a tremendous decrease, but it’s still a significant body weight decrease of around 5% which is a useful secondary benefit of the drug. The study authors also noted that women experienced greater body weight decreases on the drug than men.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAnother \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8820228\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emedical review\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e, published in the \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eObesity Facts\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e journal, examined Victoza’s weight loss effects in overweight patient populations at various doses. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAfter four months, patients on the 1.2 milligram (mg) dose lost an average of 7.4 kg, or 16.3 lbs. Patients on the 1.8 mg dose lost an average of 7.8 kg, or 17.2 lbs. The sample sizes used in this study were relatively low, which makes the data weaker in our opinion.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eVictoza seems to be effective for weight loss, but it’s not FDA-approved for weight loss so we wouldn’t recommend using the drug for weight loss alone. Patients interested in liraglutide for weight loss should speak with their doctor about Saxenda.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWhile Victoza isn’t FDA-approved for weight loss, this can still be a beneficial secondary benefit of the drug for overweight and obese patients with type-2 diabetes. This benefit may make this drug more favorable than other diabetes medications which don’t have a weight loss effect in overweight and obese patient populations.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eHow Does Victoza Work?\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eVictoza, when injected, stimulates insulin secretion in response to glucose. \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK551568\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eAccording to\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e StatPearls, which is one of the largest free medical databases in the U.S., this normalizes the insulin and glucose interaction after eating, which is dysregulated or totally absent in type-2 diabetics.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eVictoza falls into a class of medications called glucagon-like peptide-1 (GLP-1) agonists. GLP-1 receptors in the pancreas stimulate insulin release, so agonizing these receptors is the mechanism of action of this drug.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAccording to StatPearls, this type of medication can directly improve cardiovascular function by improving endothelial function and cardiac output, which is potentially why we noted reduced blood pressure as a secondary benefit of the drug in some of the above-linked research trials.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eVictoza Side Effects\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eVictoza does cause side effects in some patients, as would be expected from a medication which is injected directly into the bloodstream.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eA thorough \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8017323\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emedical review\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e published in the \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Obesity \u0026amp; Metabolic Syndrome\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e reported on the most common side effects of Victoza to be relatively mild: nausea, vomiting, dyspepsia (indigestion), constipation and diarrhea. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe side effects which are more rare are more concerning in our opinion. The research review above reports an increased risk of pancreatitis (inflammation of the pancreas), gallbladder, liver disease and heart rate. Percentage increased was not reported for these side effects, and we assume them to be rare.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAdditionally, Victoza’s \u003c\/span\u003e\u003ca href=\"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2017\/022341s027lbl.pdf\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eFDA label\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e contains a “black box” warning indicating increased risk of thyroid C-cell tumors. This type of warning is the most severe issued by the FDA, and indicates a side effect that’s potentially life-threatening.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe black box warning for Victoza notes that this risk was only proven in animal and not human studies, but it seems logical for patients with a personal or family history of thyroid disorders to speak with their doctor about alternative type-2 diabetes medications which may not confer this risk.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eVictoza Dosage\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAccording to Victoza’s \u003c\/span\u003e\u003ca href=\"https:\/\/www.victoza.com\/getting-started-on-victoza-\/your-first-injection.html\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eofficial website\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e, the medication is a once-daily injection that’s available at three separate doses: 0.6 mg, 1.2 mg and 1.8 mg. Doctors will prescribe Victoza at one of these doses based on severity of type-2 diabetes and level of insulin dysfunction experienced by the patient.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAs would be logically expected, the higher doses of Victoza are likely to be more effective, but also more likely to cause side effects.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eTypically doctors will start a patient on the lowest dose of Victoza to monitor response, and gradually increase the dose if the patient isn’t experiencing benefit. If a patient can achieve successful outcomes at the lowest dose, this is generally considered to be the best solution, because it will lower the risk of side effects.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eVictoza User Reviews\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eVictoza has been reviewed over 500 times \u003c\/span\u003e\u003ca href=\"https:\/\/www.drugs.com\/comments\/liraglutide\/victoza-for-diabetes-mellitus-type-ii.html\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eon Drugs.com\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e, which is a website where patients on prescription medication can publish reviews of their experience with a drug. The average rating of Victoza for type-2 diabetes is 7.6\/10, which is a relatively high rating.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe cannot verify the legitimacy or accuracy of any reviews on this site.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe top positive review of Victoza is written by a user named “T2D under control!” who claims that the drug was a superior alternative to Metformin for them:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e“diagnosed with type 2 diabetes 4 yrs ago. I was prescribed Metformin, then added glipizide, which made me gain a half a pound a day until I quit taking it 30 days \u0026amp; 15 lbs later. Then I was prescribed Victoza. The first 3 weeks, I was sick to my stomach, all day, every day. I had NO energy at all. I would get out of bed, get dressed \u0026amp; then lay back down - it was really THAT bad. BUT after around the 4th week, I started feeling normal again. My A1C went from 9.2 to 5.4 in just 5 weeks.”\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe top negative review of Victoza is from a user named “Lolo” who claims that the side effects of the medication were unpleasant:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e“Finished 2 weeks on victoza. 0.6 for one week then 1.2 for a week. I'm nauseous 24\/7. No appetite. No energy. Nothing tastes good anymore. I stopped talking this med. After 1 day without it, the nausea was gone, my energy returned, my appetite came back and food had flavor again.”\u003c\/b\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eVictoza Vs. Ozempic\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOzempic is another GLP-1 medication which is prescribed for type-2 diabetes. As we detailed in our recent \u003c\/span\u003e\u003ca href=\"https:\/\/illuminatelabs.org\/blogs\/health\/ozempic-review\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eOzempic for weight loss reviews\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e article, patients often ask about which of these two drugs are more effective, given that they’re in the same drug class and prescribed for the exact same conditions.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThankfully, there have been clinical trials directly comparing their efficacy.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOne such \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30122305\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003etrial\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e compared the weight loss effects of the two drugs and found that Ozempic caused significantly greater weight loss than Victoza. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eA separate \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8466858\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emedical review\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e published in 2021 compared the efficacy of the two drugs for treating type-2 diabetes, and found that Ozempic was superior. Blood sugar levels were 0.47% lower with Ozempic 1 mg compared to Victoza 1.2 mg, and 0.3% lower with Ozempic 1 mg compared to Victoza 1.8 mg.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eBased on the available research we would recommend that patients speak with their doctor about Ozempic rather than Victoza, as it may be more effective.  \u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eConclusion\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eVictoza is effective for managing type-2 diabetes, and may cause weight loss as a secondary benefit in overweight and obese patients. Since normalizing weight has favorable effects on blood sugar and metabolism, this drug may be superior to prescription type-2 diabetes medications which do not cause weight loss.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThis medication causes side effects in some patients such as nausea and indigestion. It also may increase the risk of developing certain types of cancer, which while rare, is concerning.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eVictoza appears to be inferior to Ozempic for both type-2 diabetes and weight loss based on the research we could identify. Ozempic is another prescription injectable drug which is a member of the same drug class as Victoza.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe reviews of Victoza on Drugs.com from users of the medication are more favorable than reviews of most drugs we’ve analyzed on Illuminate Health.\u003c\/span\u003e\u003c\/p\u003e","blog_id":49281925193,"author":"Calloway Cook","user_id":26601750601,"published_at":"2022-07-31T22:01:58-04:00","updated_at":"2022-08-04T17:12:21-04:00","summary_html":"We review medical studies on prescription diabetes drug Victoza to determine if it's effective for type-2 diabetes. We analyze whether the drug causes weight loss, highlight its side effects, and compare its efficacy to another popular injectable diabetes medication called Ozempic.","template_suffix":"","handle":"victoza-review","tags":"_related:diabetes, _related:weight-loss"}

Victoza Review: Are Anti-Diabetic Injections Effective?

Victoza Review: Are Anti-Diabetic Injections Effective?


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Disclaimer: None of the information in this article constitutes medical advice, and is just the opinion of the writer(s) and published for informational purposes only. We recommend that patients follow their doctor’s guidance in regard to prescription medication.

Victoza is an injectable prescription medication for type-2 diabetes. The generic form of the drug is called liraglutide, and is also the active ingredient in a prescription weight loss medication called Saxenda.

We’ll use the terms liraglutide and Victoza interchangeably throughout this article, as they refer to the same active drug ingredient.

In this article we’ll review published medical studies on Victoza to determine if it’s effective for treating type-2 diabetes. We’ll highlight potential side effects of the medication, share research-based dosage information, and compare the drug to other diabetes medications such as Ozempic.

Is Victoza Effective For Diabetes?

Victoza has been studied in many clinical trials for its effectiveness in treating type-2 diabetes.

One medical review published in the Health Technology Assessment journal found that Victoza at both of its prescribed doses was effective for reducing blood glucose on average. The researchers noted that the drug also reduced systolic blood pressure which could be considered a potential secondary benefit for patients with high blood pressure and type-2 diabetes.

Another meta-study from 2020 examined whether Victoza could be a beneficial adjunctive treatment to insulin in patients with type-1 diabetes. This means that both medications were used concurrently. 

After analyzing data from over 2,400 patients, the study authors found that Victoza reduced blood sugar levels compared to insulin alone. Those taking Victoza also required less daily insulin.

A recent medical study examined the long-term effectiveness of Victoza for diabetes, which was a useful inquiry because medical trials can often be short in duration. The researchers examined the efficacy of the drug over the course of 5 years.

Hemoglobin A1c (HbA1c) levels, which is a marker for blood sugar, decreased from an average starting point of 7.9 to 7 at the end of the trial. This represents a blood sugar decrease of 11.4%. The researchers also noted that fasting blood sugar levels experienced a “significant reduction.”

We will conclude from the available research that Victoza is effective for managing diabetes. It is effective for treating type-2 diabetes, and potentially effective for treating type-1 diabetes, but the drug is only approved by the Food and Drug Administration (FDA) in the U.S. for treating type-2 diabetes because it has more research backing for that condition.

Is Victoza Effective for Weight Loss?

Patients are often curious about whether Victoza is effective for weight loss, given that the same active drug ingredient is FDA-approved for weight loss at a higher dose, in the form of the drug Saxenda.

One of the previously-referenced studies, on the long-term outcomes of Victoza, reported on body weight changes. The study authors documented that average body weight in the overweight and obese trial population decreased from 92.1 kilograms (kg), which equates to 203 pounds (lbs) to 87.3 kg, which equates to 192.5 lbs.

This isn’t a tremendous decrease, but it’s still a significant body weight decrease of around 5% which is a useful secondary benefit of the drug. The study authors also noted that women experienced greater body weight decreases on the drug than men.

Another medical review, published in the Obesity Facts journal, examined Victoza’s weight loss effects in overweight patient populations at various doses. 

After four months, patients on the 1.2 milligram (mg) dose lost an average of 7.4 kg, or 16.3 lbs. Patients on the 1.8 mg dose lost an average of 7.8 kg, or 17.2 lbs. The sample sizes used in this study were relatively low, which makes the data weaker in our opinion.

Victoza seems to be effective for weight loss, but it’s not FDA-approved for weight loss so we wouldn’t recommend using the drug for weight loss alone. Patients interested in liraglutide for weight loss should speak with their doctor about Saxenda.

While Victoza isn’t FDA-approved for weight loss, this can still be a beneficial secondary benefit of the drug for overweight and obese patients with type-2 diabetes. This benefit may make this drug more favorable than other diabetes medications which don’t have a weight loss effect in overweight and obese patient populations.

How Does Victoza Work?

Victoza, when injected, stimulates insulin secretion in response to glucose. According to StatPearls, which is one of the largest free medical databases in the U.S., this normalizes the insulin and glucose interaction after eating, which is dysregulated or totally absent in type-2 diabetics.

Victoza falls into a class of medications called glucagon-like peptide-1 (GLP-1) agonists. GLP-1 receptors in the pancreas stimulate insulin release, so agonizing these receptors is the mechanism of action of this drug.

According to StatPearls, this type of medication can directly improve cardiovascular function by improving endothelial function and cardiac output, which is potentially why we noted reduced blood pressure as a secondary benefit of the drug in some of the above-linked research trials.

Victoza Side Effects

Victoza does cause side effects in some patients, as would be expected from a medication which is injected directly into the bloodstream.

A thorough medical review published in the Journal of Obesity & Metabolic Syndrome reported on the most common side effects of Victoza to be relatively mild: nausea, vomiting, dyspepsia (indigestion), constipation and diarrhea. 

The side effects which are more rare are more concerning in our opinion. The research review above reports an increased risk of pancreatitis (inflammation of the pancreas), gallbladder, liver disease and heart rate. Percentage increased was not reported for these side effects, and we assume them to be rare.

Additionally, Victoza’s FDA label contains a “black box” warning indicating increased risk of thyroid C-cell tumors. This type of warning is the most severe issued by the FDA, and indicates a side effect that’s potentially life-threatening.

The black box warning for Victoza notes that this risk was only proven in animal and not human studies, but it seems logical for patients with a personal or family history of thyroid disorders to speak with their doctor about alternative type-2 diabetes medications which may not confer this risk.

Victoza Dosage

According to Victoza’s official website, the medication is a once-daily injection that’s available at three separate doses: 0.6 mg, 1.2 mg and 1.8 mg. Doctors will prescribe Victoza at one of these doses based on severity of type-2 diabetes and level of insulin dysfunction experienced by the patient.

As would be logically expected, the higher doses of Victoza are likely to be more effective, but also more likely to cause side effects.

Typically doctors will start a patient on the lowest dose of Victoza to monitor response, and gradually increase the dose if the patient isn’t experiencing benefit. If a patient can achieve successful outcomes at the lowest dose, this is generally considered to be the best solution, because it will lower the risk of side effects.

Victoza User Reviews

Victoza has been reviewed over 500 times on Drugs.com, which is a website where patients on prescription medication can publish reviews of their experience with a drug. The average rating of Victoza for type-2 diabetes is 7.6/10, which is a relatively high rating.

We cannot verify the legitimacy or accuracy of any reviews on this site.

The top positive review of Victoza is written by a user named “T2D under control!” who claims that the drug was a superior alternative to Metformin for them:

“diagnosed with type 2 diabetes 4 yrs ago. I was prescribed Metformin, then added glipizide, which made me gain a half a pound a day until I quit taking it 30 days & 15 lbs later. Then I was prescribed Victoza. The first 3 weeks, I was sick to my stomach, all day, every day. I had NO energy at all. I would get out of bed, get dressed & then lay back down - it was really THAT bad. BUT after around the 4th week, I started feeling normal again. My A1C went from 9.2 to 5.4 in just 5 weeks.”

The top negative review of Victoza is from a user named “Lolo” who claims that the side effects of the medication were unpleasant:

“Finished 2 weeks on victoza. 0.6 for one week then 1.2 for a week. I'm nauseous 24/7. No appetite. No energy. Nothing tastes good anymore. I stopped talking this med. After 1 day without it, the nausea was gone, my energy returned, my appetite came back and food had flavor again.”

Victoza Vs. Ozempic

Ozempic is another GLP-1 medication which is prescribed for type-2 diabetes. As we detailed in our recent Ozempic for weight loss reviews article, patients often ask about which of these two drugs are more effective, given that they’re in the same drug class and prescribed for the exact same conditions.

Thankfully, there have been clinical trials directly comparing their efficacy.

One such trial compared the weight loss effects of the two drugs and found that Ozempic caused significantly greater weight loss than Victoza. 

A separate medical review published in 2021 compared the efficacy of the two drugs for treating type-2 diabetes, and found that Ozempic was superior. Blood sugar levels were 0.47% lower with Ozempic 1 mg compared to Victoza 1.2 mg, and 0.3% lower with Ozempic 1 mg compared to Victoza 1.8 mg.

Based on the available research we would recommend that patients speak with their doctor about Ozempic rather than Victoza, as it may be more effective.  

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Conclusion

Victoza is effective for managing type-2 diabetes, and may cause weight loss as a secondary benefit in overweight and obese patients. Since normalizing weight has favorable effects on blood sugar and metabolism, this drug may be superior to prescription type-2 diabetes medications which do not cause weight loss.

This medication causes side effects in some patients such as nausea and indigestion. It also may increase the risk of developing certain types of cancer, which while rare, is concerning.

Victoza appears to be inferior to Ozempic for both type-2 diabetes and weight loss based on the research we could identify. Ozempic is another prescription injectable drug which is a member of the same drug class as Victoza.

The reviews of Victoza on Drugs.com from users of the medication are more favorable than reviews of most drugs we’ve analyzed on Illuminate Health.





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