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Ovasitol Review: Can It Naturally Treat PCOS?

Ovasitol Review: Can It Naturally Treat PCOS?


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Read our Editorial Guidelines to learn more about what makes our site the premier resource for online health information.


Read our Editorial Guidelines to learn more about what makes our site the premier resource for online health information.

Disclaimer: None of the information in this article constitutes medical advice, and is just the opinion of the writer(s) and published for informational purposes only. We recommend that PCOS patients and women dealing with menstrual irregularities consult with their doctor prior to purchasing any dietary supplement.

Ovasitol is a women's health supplement that’s formulated to help with menstrual regularity and optimize ovarian function. It’s manufactured by a brand named Theralogix, which claims that the supplement can also help support healthy hormone levels in women and positively influence reproductive health.

In this article we’ll review Ovasitol’s formulation based on published medical research to give our take on whether these claims are likely to be true. We’ll also analyze whether any side effects are likely with use of this product.

Formulation Review

Ovasitol ingredients

Ovasitol has a simple formulation with only two active ingredients: myo-inositol at a dosage of 2,000 milligrams (mg) and d-chiro-inositol at a 50 mg dose. These are two different forms of inositol, which is a compound produced naturally by the body that affects insulin function and hormones.

The dosage instructions provided by Ovasitol recommend a twice-daily use of the supplement, resulting in a 4 gram (g) total dose of myo-inositol and a 100 mg total daily dose of d-chiro-inositol.

One medical trial using these two ingredients at nearly the exact same dose proved that ovulation was able to be restored in Polycystic Ovary Syndrome (PCOS) patients. The trial participants took the same forms of inositol as in Ovasitol at the exact same ratio (40:1), and progesterone levels were significantly increased by nearly 50x. These findings validate Ovasitol’s claim that their product could improve reproductive health in women.

A separate medical study found that myo-inositol and d-chiro-inositol improved menstrual regularity in women with PCOS. Their average menstrual cycle length decreased from 124.5 days to 57.8 days, which is an impressive change. Their markers of insulin resistance also decreased. These findings suggest that Ovasitol’s claims about their supplement aiding with menstrual regularity and insulin function may be accurate, particularly for patients with PCOS.

A medical study from 2017, published in the European Review for Medical and Pharmacological Sciences, evaluated the effects of myo-inositol on insulin-resistant women. The researchers found that myo-inositol had “significantly beneficial” effects on progesterone levels (a sign of fertility) and pregnancy rates. The group taking myo-inositol were also taking 400 micrograms (mcg) of folic acid, so we can’t attribute these results to the inositol alone. That being said, this study is important because it proved the efficacy of inositol in women without PCOS.

Based on the available research we would recommend this supplement for patients with PCOS, but we don’t believe there’s enough data to prove it’s effective for women without PCOS. The vast majority of studies we reviewed on inositol supplementation were on women with PCOS. 

We’re not suggesting this supplement is harmful for women without PCOS, just that there appears to be less medical research at this point in time suggesting it to be effective. Women without PCOS may wish to speak to their doctor about taking Ovasitol to ensure they’re not wasting their money.

One benefit of this formulation is that it contains no harmful additive ingredients. It’s an unflavored powder with no added sugars, flavorings or other chemical agents that we often find in supplements we review. 

Ovasitol Side Effects

Ovasitol claims that their supplement is unlikely to cause any side effects. In an FAQ section on their site, the brand states the following: “There are no expected side effects from Ovasitol.”

Medical research backs this claim. An extensive meta-study of inositol, which analyzed data from many individual studies, found that only the highest dose of inositol (which was 12 g per day, or 3x the amount in Ovasitol) caused side effects, and even then the side effects were minor such as nausea and gas.

Even in women with PCOS, there are apparently no side effects. A medical review found that 4,000 mg of myo-inositol (the exact dose and type in Ovasitol) caused no side effects compared to a placebo group: “No relevant side effects were present among the patients.”

It’s rare to find a compound with demonstrated clinical efficacy and no reported side effects. This should be a great sign for women considering this product, or considering inositol supplementation generally.

Can Ovasitol Cause Weight Loss?

Many consumers ask whether Ovasitol can cause weight loss, and it’s a reasonable question. Inositol helps regulate insulin sensitivity, and we know from previous medical research that dysregulated insulin sensitivity is associated with weight gain. 

It logically follows that normalizing insulin sensitivity through supplementation of inositol could theoretically cause weight loss in overweight adults, if the cause of their weight gain was dysregulated insulin sensitivity.

Medical research suggests that Ovasitol may cause weight loss in overweight adults.

A medical trial on overweight and obese women with PCOS found that myo-inositol supplementation combined with diet caused improved weight loss outcomes compared with diet alone. The dosage used was exactly the same dosage in Ovasitol (4 g).

A separate study on overweight women without PCOS showed similar efficacy. Over a 12 month period, supplementation with inositol caused a 5% decrease in body mass index (BMI), compared with a negligible difference in a control group. 

These results suggest that Ovasitol may be effective for moderate weight loss in overweight women with or without PCOS.

NSF Certification

Ovasitol is NSF certified, which is a sign of a quality brand. The NSF is a non-profit organization that analyzes both quality control metrics of manufacturers (like facility inspections for sanitation) and quality control metrics for products (like contaminant levels and label accuracy).

Put simply, a supplement that’s NSF certified is less likely to be contaminated. This is an important consideration in the U.S. supplement market, which has no required pre-approvals.

In January of 2020, over 800 individual supplement brands were forced to recall their products by the Food and Drug Administration (FDA) in the U.S. due to failures of good manufacturing practice which could have resulted in tainted supplements. Incidents like these help to clarify why certifications and published product test results are so important for U.S. supplement brands to prove the safety of their products.

Ovasitol User Reviews

Ovasitol has generally favorable reviews on Amazon. Their powder supplement is rated 4.6 stars out of 5, and 80% of reviewers have rated the product 5 stars.

Ovasitol powder receives an F rating on FakeSpot, which is an algorithm which detects potentially fraudulent reviews. This is a minor red flag, which suggests that some of the Amazon reviews may not be legitimate.

The most helpful positive review comes from a verified purchaser named “Em” who claims that the supplement helped her achieve menstrual regularity:

“I first started using this October 11,2018 and on November 5,2018 I have gotten my period!!!!! . I Thank god that I ran across this because This is amazing !!”

The most helpful negative review comes from a verified purchaser named “Samantha Crandall” who claims that the lower-dosed ingredient in Ovasitol (d-chiro-inositol) negatively affects fertility:

“This product literally has an ingredient in it that is the complete opposite of what it claims to do.”

Her claim is technically correct but we don’t believe the concern is warranted, because the study she references uses a minimum dose which is 3x higher than the dose in Ovasitol. D-chiro-inositol has not been proven harmful to human fertility at the dose in Ovasitol.

One of the most popular YouTube reviews comes from a creator named “Stephanie Amanda” who used the supplement for 90 days and claims it helped with many of her symptoms:

Ovasitol Price

The price of Ovasitol on their website is $80 for a one-time purchase and $70 for a subscription purchase. The product contains 180 servings and 2 servings per day are recommended. This equates to a $0.89 cost per day.

The price of Ovasitol on Amazon is currently $87.00 for a one-time purchase of the same product. This equates to a $0.97 cost per day.

We recommend purchasing Ovasitol through the manufacturer’s website as there is no benefit to purchasing it on Amazon, so going for the lower price makes sense.

Ovasitol Pros and Cons

Here’s our summary of this product:

Pros: 

  • Effective formulation
  • No harmful additive ingredients
  • Research-backed dosage
  • Appears especially effective for women with PCOS
  • No side effects
  • NSF certified

Cons:

  • Poor Amazon review score from FakeSpot
  • This specific supplement not tested in any clinical research
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Conclusion

Ovasitol is one of the better supplement brands we’ve recently reviewed, and we would recommend it, especially to women with PCOS. The formulation is backed by clinical research and is unlikely to cause any side effects. The types of inositol in Ovasitol are proven to aid with menstrual regularity and fertility, and may even cause a modest reduction in weight in women who are overweight with insulin dysregulation.





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