Lipozene is a weight loss supplement that’s available online and at Walmart. It’s very popular, having sold over 35 million bottles since their launch.
In this article we’ll review the ingredients in Lipozene, as well as their other supplement Metaboup Plus, based on medical research to determine if they’re likely to be safe and effective for weight loss. We’ll also highlight some marketing strategies they’re employing which we believe to be actively deceptive.
Does Lipozene Work?
Lipozene only has one active ingredient: 1500 milligrams (mg) of amorphophallus konjac, a fibrous plant native to Asia.
We know from medical research that fiber supplementation generally aids in weight loss efforts, but that doesn’t mean this product will be effective. The dosage and form of fiber matters.
It’s unclear to us what’s actually in Lipozene, because their Supplement Facts label states amorphophallus konjac, but the footer of their site and their Walmart listing lists a separate ingredient called glucomannan.
Glucomannan, according to medical research, is purified konjac flour. So the two terms don’t appear to be interchangeable and it doesn’t seem like Lipozene even knows how to properly botanically identify the one single ingredient in their formulation.
When a botanical ingredient undergoes a processing or purifying process, it experiences biochemical changes that affect the way it impacts the body. Both ginkgo biloba leaf and ginkgo biloba extract are made from the same raw material, but the latter ingredient is more potent due to the extraction process.
A clinical trial published in the Journal of Obesity found that konjac glucomannan did not promote weight loss in overweight individuals. The study participants were taking 3.99 grams (g) daily, which is nearly 3x more than that contained in Lipozene.
A more recent medical review analyzed whether glucomannan supplementation was effective for weight loss. The researchers found nine different medical trials on this topic, and concluded that “The evidence from available randomized controlled trials does not show that glucomannan intake generates statistically significant weight loss.”
We don’t believe that Lipozene is likely to be effective at all based on the available research.
As a minor side note, the product also contains artificial food dye which we know is a health risk based on medical research.
We recommend avoiding this product.
Deceptive Marketing Practices
Lipozene’s physical product labels and website contain a seal of approval from a group called the “Obesity Research Institute.”
At first glance, this appears to be an independent trade group that certifies high-quality weight loss products, and that’s certainly what Lipozene wants you to think.
The company that manufactures Lipozene is called the Obesity Research Group LLC, and you can find that information in the footer of their site.
We find this to be incredibly deceptive, and potentially false advertising, as most consumers won’t be able to easily identify that this award doesn’t actually signify anything, or come from an outside organization.
What they’re doing is like if Apple had a holding company called Computer Grades LLC which printed flyers stating that Apple received top awards for Computer Grades’ “Computer of the Year” award.
It’s marketing material that’s intentionally designed to look like an outside certification, and we strongly disagree with this type of marketing ethically.
Lipozene also claims on their site that “Lipozene is clinically proven to help you lose weight. In a clinical study...one group of participants was given Lipozene while the other was given a placebo.”
We can’t find the study they’re referring to in any published medical journal, and they don’t link out to it or mention where users can find this clinical study, so we’re going to assume this is totally made up.
A supplement company claiming that their products are clinically proven to work without any proof is a huge red flag.
Lipozene Side Effects
Since glucomannan is a type of dietary fiber, there shouldn’t be any significant side effects to its supplementation.
One of the research articles on the compound that we linked previously stated that glucomannan has a favorable safety profile, but also noted that there wasn’t enough long-term research to definitively say it’s safe for long-term use.
We believe that this is a relatively low risk ingredient, but agree that it should be studied in long-term studies.
We can’t find any medical data suggesting that glucomannan has side effects, even when used at doses higher than in Lipozene.
Patients who consume a low-fiber diet containing processed foods may experience some digestive discomfort when they begin taking a fiber supplement, but that’s not unique to Lipozene. That experience is likely when increasing intake of any type of fiber, which is why we recommend it’s increased gradually in the diet.
Does Metaboup Plus Work?
The other supplement sold on Lipozene’s site is called Metaboup Plus. The company claims its “quality vitamins and antioxidants” can support weight loss goals, which sounds unscientific right off the bat since we haven’t seen any research suggesting that random blends of vitamins and antioxidants support weight loss.
The product contains a proprietary (prop) blend of which green tea extract is the first ingredient. As this medical review summarized, while green tea extract may be effective for weight loss short-term, it’s a risky supplement because of the potential hepatotoxicity (liver-damaging) effects of high doses of polyphenols from green tea.
There is no similar studied effect for regular green tea consumption in moderation, so patients shouldn’t have to worry about that. It’s that green tea supplements have much more potent doses of some of the chemical compounds which the liver has to process.
In the context of the health risks involved with green tea extract, it’s totally unacceptable for the manufacturer to list this ingredient as part of a prop blend where the individual dose is hidden. Any risky ingredients should have a dose listed so that consumers and researchers can determine if the dose is likely to be safe.
The second ingredient in this product called guarana seed extract may be effective for weight loss based on a medical review, but we believe the research is too early-stage to definitively say. In any case, the manufacturer doesn't even publish the individual dose of the ingredient which makes it impossible to assess its safety and effectiveness.
We believe that Metaboup may be effective for weight loss based on the ingredients used, but we don’t recommend it due to the safety risks.
Because the manufacturer lists the active botanical ingredients as part of a prop blend rather than listing the doses of each ingredient, there is no way to definitively say whether the product should work or not.
There are many safer weight loss options that we believe patients should consider over this product.