Bio Complete 3 is a gut health supplement manufactured by Gundry MD. The company claims their product has prebiotic, probiotic and postbiotic ingredients to support optimal gut function. They also make some somewhat surprising health claims for a probiotic supplement, such as potential weight loss and increased energy.
In this article we’ll review the ingredients in Bio Complete 3 to determine whether it’s likely to actually improve gut function, and whether it’s worth the high cost of $69.95 per bottle.
Since the brand advertises the prebiotic, probiotic and postbiotic function of their supplements, we’ll structure our review to analyze each of these separately.
Ingredient Review - Prebiotics
There is one active prebiotic ingredient in Bio Complete 3, which is 200 milligrams (mg) of a fiber product called “Sunfiber”. It’s made from fermenting Indian guar beans.
This specialized fiber product appears to be safe and well-tolerated based on medical research, but we haven’t come across any studies suggesting it’s superior to regular fiber from food or supplements.
We know from extensive medical research that adequate dietary fiber intake is essential for optimal functioning of the microbiome (bacterial balance of the gut), and metabolism, but if this specialized ingredient isn’t superior to regular fiber intake, then it seems like a much more expensive way to increase fiber intake.
The 200 mg dose of prebiotics in Bio Complete 3 also appears to be very low. Even a review of Sunfiber published in a medical journal highlighted how the World Health Organization (WHO) has a recommended daily fiber intake of 37 grams (g).
1 g = 1000 mg, so the dose of fiber in Bio Complete 3 is 0.5% of the WHO recommended intake. This is so low as to be essentially worthless in our opinion.
Ingredient Review - Probiotics
The probiotic in Bio Complete 3 is a patented version of Bacillus coagulans called ProDura. We can’t find any research suggesting this specialized probiotic is superior to other strains of Bacillus coagulans for optimizing gut function, or superior to any other type of probiotic.
It may be effective, but we’re not seeing any research that justifies the added cost over a standard probiotic supplement, and Gundry MD doesn’t provide any.
We also find it strange that the listed dose of ProDura is in milligrams, when probiotics are almost always listed in colony-forming units (CFUs).
The 16 mg of ProDura appears underdosed when compared to the amount of Bacillus coagulans used in medical studies. One clinical trial on probiotic supplementation for Irritable Bowel Syndrome (IBS) used a Bacillus coagulans dose of 333.33 mg.
Another medical study used the exact same Bacillus coagulans dose: 333.33 mg.
Now maybe ProDura is vastly more efficient, and can provide the same benefit as other strains of the same probiotic species when used in much lower quantities, but we haven’t seen any proof of this, and Gundry MD doesn’t provide any clinical data suggesting so, so we will conclude that the probiotic in Bio Complete 3 is likely to be underdosed and ineffective.
Ingredient Review - Postbiotics
Bio Complete 3 includes a “postbiotic” ingredient called CoreBiome manufactured by a company called Compound Solutions. It appears to be a short-chain fatty acid because it’s standardized for tributyrin, but Compound Solutions doesn’t even publish what the ingredient is composed of on their website; suggesting instead that users contact them for more info. Not exactly very transparent for a consumable product manufacturer.
We can’t find any medical studies at all proving the efficacy and safety of this ingredient, so we recommend avoiding it.
Misleading Health Claims
Based on the previous research summary, we find it to be misleading that Gundry MD is making health claims about Bio Complete 3.
The company claims their supplement improves gut function, aids in weight loss and can increase energy without linking out to any relevant research proving so.
There are no clinical trials testing Bio Complete 3 for improving gut function (or for safety), and even the active ingredients used appear to have lacking clinical research behind them based on our review.
If you’re selling a supplement with a proprietary blend like Bio Complete 3, and do not fund clinical research proving that unique blend is effective, we believe it’s unethical to make aggressive health claims for marketing purposes.
As we’ve stated in previous reviews of probiotic supplements like ProbioSlim, we don’t feel as though there’s enough clinical evidence to support probiotic supplementation for healthy adults.
For patients with specific disease states like IBS, targeted strains of probiotics may be beneficial, but for healthy adults we believe that getting probiotics from food products is a much cheaper, safer and more effective way to optimize gut function.
Fermented foods like kefir are a great way to significantly increase your probiotic intake at your next trip to the grocery store. Kefir is a fermented dairy product much like yogurt that’s high in naturally-occurring probiotics.
A medical review of studies on kefir consumption found that its intake was associated with improved digestion, and that it may have anti-hypertensive (blood pressure lowering) and anti-inflammatory effect.
Another healthy fermented food which is even cheaper and more accessible than kefir is tempeh, which is made from fermented soybeans.
A review of the health benefits of tempeh published in the Nutrition Reviews journal found that it lowered cholesterol levels and reduced incidence of diarrhea, suggesting it’s beneficial for the gut.
Not only are these whole foods probiotics likely to provide more CFU of probiotics than supplements, but they also contain healthy micronutrients which provide additional health benefit beyond the probiotic function.