Arthrozene Review: Is Natural Pain Relief Possible?

Arthrozene Review: Is Natural Pain Relief Possible?

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​​Disclaimer: None of the information in this article constitutes medical advice, and is just the opinion of the writer(s). We recommend that patients follow their doctor’s guidance in regard to pain relief.

Arthrozene is a pain relief supplement that claims to "soothe discomfort," "ease stiffness" and improve flexibility and mobility. The brand claims that these results can be seen in as little as five days.

But can an over-the-counter (OTC) supplement really provide dramatic pain relief or are these just marketing claims? Are the ingredients in Arthrozene proven to work? Does the supplement contain any unhealthy additive ingredients? And is it likely to cause side effects?

In this article we’ll answer all of these questions and more as we review every ingredient in Arthrozene based on medical studies to give our take on whether the supplement is likely to be effective, and explain whether it's likely or not to cause side effects. We'll also share a real, unsponsored user review of this supplement.

Ingredient Review

Arthrozene ingredients

Arthrozene only has three active ingredients: Boswellia serrata extract, chicken comb extract and collagen.

Boswellia serrata extract is an herbal extract sourced from a tree native to the Arabian peninsula. We consider it effective for pain relief.

A clinical trial on this ingredient at same dosage as in Arthrozene found that it was significantly more effective than placebo at reducing pain and improving joint function.

A medical review published in the BMC Complementary Medicine and Therapies journal analyzed data from seven clinical trials on Boswellia and pain, and concluded the following: "Based on current evidence, Boswellia and its extract may be an effective and safe treatment option for patient with [osteoarthritis]".

Natural chicken comb extract is the second ingredient in this supplement, and a patented extract called “Mobilee” is used. This extract has been tested in medical research and proven to be effective for pain reduction.

A 2014 clinical trial on healthy volunteers with joint irritation compared Mobilee with a placebo for pain management. The group taking Mobilee had significant pain reduction. The dosage used in the study is the exact same as that in Arthrozene.

An animal study on chicken comb extract found similarly impressive results. Dogs with osteoarthritis who consumed this ingredient experienced “improvements in osteoarthritis biomarkers.”

The final ingredient in Arthrozene is another patented compound called “B-2Cool” and is Type II Native Collagen. The dose is quite low at only 40 mg. 

As we documented in our Instaflex reviews article, collagen is an effective pain relief ingredient but we've only seen studies using much higher doses than 40 mg (typically above 2,000 mg). Thus we will consider this ingredient underdosed.

Overall we consider Arthrozene to be likely to cause pain relief, given that all three of its active ingredients have research backing for pain relief, and we consider two of those ingredients to be effectively dosed.

It’s also worth noting that all of the inactive ingredients used in Arthrozene are safe and non-toxic, which is not always the case with supplements. There are no unhealthy filler ingredients like flavoring agents or artificial dye.

We do not recommend this supplement because we believe there are better options on the market for a price much lower than the $69.95 that Arthrozene costs, but we have no issues with consumers taking this supplement and we do not consider its use to be a health risk.

Does Arthrozene Cause Side Effects?

 Consumers are often curious about whether Arthrozene is likely to cause side effects, given that prescription pain medication is often addictive and may carry the risk of serious side effects.

Based on the active ingredients, we do not consider Arthrozene likely to cause side effects. All three active ingredients in this formulation are well-studied and non-toxic. None of the ingredients are included at a dangerously high dose. And as stated in the previous section, there are no questionable or unhealthy inactive ingredients in Arthrozene.

This doesn't mean that Arthrozene will be side-effect-free for all users. Any individual can react negatively to any supplement (or food). This just means that we do not consider Arthrozene to be dangerous or pose a risk of side effects for the average consumer.

Arthrozene Real User Review

One of the only reviews of Arthrozene on YouTube that we consider likely unsponsored is published by a channel called "Supplement Critique." The creator shares his experience using Arthrozene and explains whether it reduced his joint pain:

Can Food-Based Supplements Relieve Pain?

Cinnamon is a spice that has been studied for its ability to reduce pain and support joint health.

clinical trial published in the Journal of the American College of Nutrition found that cinnamon supplementation at a daily dose of 500 mg reduced inflammation and joint swelling in patients with rheumatoid arthritis.

A 2020 clinical trial found that cinnamon supplementation reduced inflammatory markers. The study authors concluded that “Cinnamon could be regarded as a safe supplement to relieve pain.”

Illuminate Labs manufactures a Ceylon Cinnamon Extract supplement that’s potent (standardized to minimum 8% flavonoids) and third-party tested to ensure purity and label accuracy (test results published transparently on the product page). It only costs $15 for a monthly subscription.

Interested consumers can check out Illuminate Labs Ceylon Cinnamon Extract at this link.

Collagen is the core structural protein in joints. The body produces it naturally, but its production decreases with age. Medical research has shown that collagen can reduce joint pain in athletes at a 10 gram (g) daily dose, and can reduce arthritic pain (meta-study, doses ranging between 40 mg and 10 g daily dose).

We recommend Bulletproof Collagen Powder as our top collagen product because it provides an effective collagen dose per serving (20 g) and contains one single ingredient: collagen peptides sourced from grass-fed animals. There are no questionable additives. This supplement only costs $45.16 for over a month's worth of product.

Interested consumers can check out Bulletproof Collagen powder at this link to the brand's official website.

Cornbread CBD Lotion is our top pick for a topical CBD product.

CBD is clinically shown to be effectively absorbed through the skin, and CBD caused "significant improvements in pain" when applied topically in a 2020 clinical trial.

This lotion also contains menthol, which was shown in a 2022 clinical trial to reduce pain scores.

Interested consumers can check out Cornbread CBD Lotion at this link to the product page on the official brand's website.

We do not recommend using dietary supplements to treat any specific medical condition related to pain, and we recommend that individuals speak with their doctor prior to using any supplement for pain relief.

Arthrozene Pros and Cons

Here's our take on the pros and cons of Arthrozene as a brand.


  • Effective active ingredients
  • No questionable additive ingredients
  • Unlikely to cause side effects


  • Expensive
  • Terrible branding
  • Doesn't appear available for sale on Amazon or Walmart
Stay up-to-date on our research reviews


Arthrozene is better-formulated than most of the pain relief supplements we review on Illuminate Health. All three of its active ingredients have legitimate research backing, and we consider two of them to be effectively dosed.

We think it’s a good thing that Arthrozene uses patented botanical ingredients, as these tend to have more research backing than generic botanical extracts.

We don't recommend Arthrozene overall due to its high cost, but we have no issues with consumers using the supplement as we do not consider it harmful or likely to cause side effects.

Arthrozene does not appear to be sold on Amazon or Walmart by the official manufacturer, so for consumers who plan to purchase this supplement, we would recommend doing so on the official manufacturer's website only.

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