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{"id":556086526025,"title":"Arthrozene Review: Is Natural Pain Relief Possible?","created_at":"2021-12-27T02:13:31-05:00","body_html":"\u003cscript type=\"application\/ld+json\"\u003e\/\/ \u003c![CDATA[\n{\n \"@context\": \"https:\/\/schema.org\",\n \"@type\": \"Article\",\n \"headline\": \"Arthrozene Review: Is Natural Pain Relief Possible?\",\n \"keywords\": \"arthrozene, arthrozene review, arthrozene reviews, arthrozene ingredients\",\n \"description\": \"Our MD and research team reviews the ingredients in Arthrozene based on medical research to determine if it’s likely to be effective. We compare it to other popular pain relief supplements, and highlight an issue we have with a lack of product testing by the manufacturer.\",\n \"url\": \"https:\/\/illuminatelabs.org\/blogs\/health\/arthrozene-review\",\n\"author\": {\n \"@type\": \"Person\",\n \"name\": \"Taylor Graber MD\",\n \"url\": \"https:\/\/illuminatelabs.org\/pages\/taylor-graber\",\n \"sameAs\": \"https:\/\/www.linkedin.com\/in\/taylor-j-graber-md-81351642\/\",\n \"jobTitle\": \"Content Partner\",\n \"knowsAbout\": \"medicine, health, anesthesiology, iv therapy, science, drugs, pharmaceutical, medical research, scientific research, medical journals, entrepreneurship, healthcare, orthopedic surgery, biomedical engineering\",\n \"alumniOf\": {\n \"@type\": \"EducationalOrganization\",\n \"name\": [\n \"University of California San Diego\",\n \"Arizona University\",\n \"University of Arizona College of Medicine\"\n ]\n },\n \"memberOf\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n }\n},\n\"contributor\": {\n \"@type\": \"Person\",\n \"name\": \"Calloway Cook\",\n \"url\": \"https:\/\/illuminatelabs.org\/pages\/calloway-cook\",\n \"sameAs\": \"https:\/\/www.linkedin.com\/in\/calloway-cook\/\",\n \"jobTitle\": \"President\",\n \"knowsAbout\": \"entrepreneurship, dietary supplements, herbal supplements, eCommerce, medical research\",\n \"alumniOf\": {\n \"@type\": \"EducationalOrganization\",\n \"name\": \"S.I. Newhouse School of Public Communications at Syracuse University\"\n },\n \"memberOf\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n }\n},\n\"editor\": {\n \"@type\": \"Person\",\n \"name\": \"DJ Mazzoni\",\n \"honorificSuffix\": [\n \"M.S.\",\n \"R.D.\",\n \"C.D.N.\",\n \"C.S.C.S.\"\n ],\n \"url\": \"https:\/\/illuminatelabs.org\/pages\/dj-mazzoni\",\n \"sameAs\": \"https:\/\/www.linkedin.com\/in\/dj-mazzoni-rd-cdn-cscs-00a33038\/\",\n \"jobTitle\": \"Medical Reviewer\",\n \"knowsAbout\": \"exercise, drugs, pharmaceutical, health, workout, strength and conditioning, nutrition, dietetics, medicine, medical research, scientific research, scientific method, healthcare, patient care, wellness\",\n \"alumniOf\": {\n \"@type\": \"EducationalOrganization\",\n \"name\": [\n \"State University of New York College Oswego\",\n \"D’Youville College\"\n ]\n },\n \"memberOf\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n }\n},\n\"image\": {\n\"@type\": \"ImageObject\",\n\"url\": \"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Arthrozene_Thumbnail.jpg?v=1642222748\",\n\"width\": \"3750\",\n\"height\": \"3750\"\n},\n\"citation\": [\n\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3198257\/\", \n\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4172652\/\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33925642\/\",\n\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4970562\/\",\n\"https:\/\/illuminatelabs.org\/blogs\/health\/relief-factor-review\",\n\"https:\/\/illuminatelabs.org\/blogs\/health\/bluebird-botanicals-review\",\n\"https:\/\/www.fda.gov\/safety\/recalls-market-withdrawals-safety-alerts\/abh-natures-products-inc-abh-pharma-inc-and-stocknutracom-inc-issues-nationwide-recall-all-lots\"\n],\n\"datePublished\": \"2021-12-28\",\n\"copyrightHolder\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n},\n\"publisher\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\",\n \"url\": \"https:\/\/illuminatelabs.org\/\",\n \"description\": \"Illuminate Labs is the most transparent supplement company in the U.S., and is a leading publisher of research-based health information.\",\n \"knowsAbout\": \"supplements, science, nutrition, exercise, health, medication, pharmaceutical, wellness, diet, weight loss, medical research\",\n \"publishingPrinciples\": \"https:\/\/illuminatelabs.org\/pages\/editorial-guidelines\",\n \"logo\": {\n \"@type\": \"ImageObject\",\n \"url\": \"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Illuminate_Labs_Logo.png?v=1641249064\", \n \"width\": 150,\n \"height\": 150\n},\n \"foundingDate\": \"2019-01-30\",\n \"Address\": {\n \"@type\": \"PostalAddress\",\n \"streetAddress\": \"50 Union Street, Unit 9\",\n \"addressLocality\": \"Northampton\",\n \"addressRegion\": \"Massachusetts\",\n \"postalCode\": \"01060\",\n \"addressCountry\": \"US\"\n},\n \"sameAs\": [\n \"https:\/\/www.instagram.com\/illuminatelabs\",\n \"https:\/\/twitter.com\/illuminatelabs\",\n \"https:\/\/www.linkedin.com\/company\/illuminate-labs-supplements\",\n \"https:\/\/www.youtube.com\/channel\/UCpgSJAsIPb-fZ25djtTxBEA\"\n ]\n }\n}\n\/\/ ]]\u003e\u003c\/script\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Arthrozene_Review_Article_Header_Image.png?v=1640589743\" alt=\"\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan class=\"dc\"\u003eA\u003c\/span\u003erthrozene is a supplement for joint pain. It claims to provide pain relief and increase flexibility and mobility. The brand also has potentially the worst bottle design we’ve ever seen for a supplement but that’s another issue.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIn this article we’ll review the ingredients in Arthrozene based on medical research to determine if it’s likely to be effective. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eIngredient Review\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cb\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Arthrozene_Ingredients_828f469d-0232-43f1-b74b-003209778ef6.png?v=1640589876\" alt=\"Arthrozene ingredients\" style=\"display: block; margin-left: auto; margin-right: auto;\"\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eArthrozene only has three active ingredients: boswellia serrata extract, chicken comb extract and collagen.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eBoswellia serrata extract\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e is an herbal extract sourced from a tree native to the Arabian peninsula. The dosage in Arthrozene of 100 milligrams (mg) may be effective for arthritis pain.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eA \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3198257\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eclinical trial\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e on this ingredient at the 100 mg dosage found that it was significantly more effective than placebo at reducing pain and improving joint function. It’s important to note that this study was funded by the company that manufactures the patented boswellia compound used in Arthrozene, so there is significant bias inherent in this study.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe recommend considering the results of company-sponsored research as somewhat useful but less trustworthy than independent research. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe website of the patent holder of the boswellia extract references two scientific studies proving it works, but we can only find one unique clinical trial; the one linked to above. The other publication appears to be simply a review of the previous trial with some further descriptions of the biological mechanisms involved.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eSo if there is only one company-sponsored study proving this ingredient is effective for arthritis pain, we would consider that weak evidence overall (though definitely better than nothing).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e80 mg of \u003c\/span\u003e\u003cb\u003enatural chicken comb extract\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e is the second ingredient in this supplement, and a patented extract called “Mobilee” is used. This extract has been tested in medical research and proven to be effective for pain reduction.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eA \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4172652\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eclinical trial\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e on healthy volunteers with joint irritation compared Mobilee with a placebo for pain management. The group taking Mobilee had significant pain reduction. The dosage used in the study is the exact same as that in Arthrozene.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe above-linked study was partially funded by a European grant program and partially funded by the patent-holding company, which makes the research more objective than that of the boswellia extract.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAn \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33925642\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eanimal study\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e on this chicken comb extract found similarly impressive results. Dogs with osteoarthritis who consumed this ingredient experienced “improvements in osteoarthritis biomarkers.”\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOverall this appears to be an effective ingredient for joint pain, even though the research is early-stage.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe final ingredient in Arthrozene is another patented compound called “B-2Cool” and is \u003c\/span\u003e\u003cb\u003eType II Native Collagen\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e. The dose is quite low at only 40 mg.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe don’t believe this to be an effective ingredient dosage, as the patent holder’s website doesn’t appear to publish any medical research proving this ingredient alone is effective for joint pain at the 40 mg dosage.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThere is \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4970562\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eone medical study\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e showing that this collagen ingredient at a dosage of only 10 mg in combination with 1,500 mg of acetaminophen is effective for treating pain, but this isn’t an impressive or surprising result given that acetaminophen is the active ingredient in Tylenol and is one of the most widely-used pharmaceutical analgesics (pain-relievers) in the world.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIt’s almost certainly the effects of acetaminophen and not the minute dosage of collagen causing the pain relief, which is why we feel this is a poorly designed study.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOverall this product is pretty well formulated, especially in comparison with other natural pain relief supplements we’ve reviewed previously like \u003c\/span\u003e\u003ca href=\"https:\/\/illuminatelabs.org\/blogs\/health\/relief-factor-review\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eRelief Factor\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAll three of the active ingredients appear to be effective for pain relief, and two of them appear to be effectively dosed.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIt’s also worth noting that all of the inactive ingredients used in Arthrozene appear to be safe and non-toxic, which is not always the case with supplements.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eNo Published Test Results\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eArthrozene doesn’t publish any test results, performed in-house or by a third-party, to prove that their product is accurately labeled (contains the listed ingredients at the listed dosages) and pure (contains low or undetectable levels of contaminants such as heavy metals and pesticides).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThis issue isn’t unique to Arthrozene; very few supplement companies publish testing to prove their products are safe and effective (\u003c\/span\u003e\u003ca href=\"https:\/\/illuminatelabs.org\/blogs\/health\/bluebird-botanicals-review\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eBluebird Botanicals\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e is one of the few that does).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe don’t recommend supplements from companies that don’t publish testing due to the serious contamination and mislabeling issues in the U.S. supplement market. In 2020 alone 800 individual supplement brands \u003c\/span\u003e\u003ca href=\"https:\/\/www.fda.gov\/safety\/recalls-market-withdrawals-safety-alerts\/abh-natures-products-inc-abh-pharma-inc-and-stocknutracom-inc-issues-nationwide-recall-all-lots\"\u003e\u003cspan style=\"font-weight: 400;\"\u003ewere ordered\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e to remove all of their products from the market by the Food and Drug Administration (FDA) due to violations of good manufacturing practice.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003ePut simply, we believe that if you as a consumer can’t see independent test results proving that a dietary supplement contains the listed ingredients and low levels of contaminants, you have no reason to trust the company.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eConclusion\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eArthrozene is a decently formulated dietary supplement for joint pain. It is better-formulated than most supplements we’ve reviewed, given that all of its active ingredients work to positively impact the stated health claim, and two of them appear to be effectively dosed based on limited medical research.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe don’t recommend this product because one of the ingredients appears to be ineffectively dosed (or at the least there isn’t any data we could find proving it’s effective at the given dose), and because the company doesn’t publish any testing proving that their product is accurately labeled and as potent as advertised.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe think it’s a good thing that Arthrozene uses patented compounds, as these tend to have more research backing them and a more standardized effect profile. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe don’t believe this formulation is harmful assuming it’s low in contaminants, and it may help for joint pain given its ingredients.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIf Arthrozene publishes test results of their product in the future we will consider revising this review and recommending the product because of its formulation which is mostly backed by scientific research.\u003c\/span\u003e\u003c\/p\u003e","blog_id":49281925193,"author":"Calloway Cook","user_id":26601750601,"published_at":"2021-12-28T12:00:00-05:00","updated_at":"2022-08-18T20:05:01-04:00","summary_html":"We review the ingredients in natural pain relief supplement Arthrozene based on medical research to determine if it’s likely to be effective. We compare it to other popular pain relief supplements, and highlight an issue we have with a lack of product testing by the manufacturer.","template_suffix":"","handle":"arthrozene-review","tags":"_related:arthritis, _related:pain-relief"}

Arthrozene Review: Is Natural Pain Relief Possible?

Arthrozene Review: Is Natural Pain Relief Possible?


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Read our Editorial Guidelines to learn more about what makes our site the premier resource for online health information.
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Read our Editorial Guidelines to learn more about what makes our site the premier resource for online health information.


Read our Editorial Guidelines to learn more about what makes our site the premier resource for online health information.

Arthrozene is a supplement for joint pain. It claims to provide pain relief and increase flexibility and mobility. The brand also has potentially the worst bottle design we’ve ever seen for a supplement but that’s another issue.

In this article we’ll review the ingredients in Arthrozene based on medical research to determine if it’s likely to be effective. 

Ingredient Review

Arthrozene ingredients

Arthrozene only has three active ingredients: boswellia serrata extract, chicken comb extract and collagen.

Boswellia serrata extract is an herbal extract sourced from a tree native to the Arabian peninsula. The dosage in Arthrozene of 100 milligrams (mg) may be effective for arthritis pain.

A clinical trial on this ingredient at the 100 mg dosage found that it was significantly more effective than placebo at reducing pain and improving joint function. It’s important to note that this study was funded by the company that manufactures the patented boswellia compound used in Arthrozene, so there is significant bias inherent in this study.

We recommend considering the results of company-sponsored research as somewhat useful but less trustworthy than independent research. 

The website of the patent holder of the boswellia extract references two scientific studies proving it works, but we can only find one unique clinical trial; the one linked to above. The other publication appears to be simply a review of the previous trial with some further descriptions of the biological mechanisms involved.

So if there is only one company-sponsored study proving this ingredient is effective for arthritis pain, we would consider that weak evidence overall (though definitely better than nothing).

80 mg of natural chicken comb extract is the second ingredient in this supplement, and a patented extract called “Mobilee” is used. This extract has been tested in medical research and proven to be effective for pain reduction.

A clinical trial on healthy volunteers with joint irritation compared Mobilee with a placebo for pain management. The group taking Mobilee had significant pain reduction. The dosage used in the study is the exact same as that in Arthrozene.

The above-linked study was partially funded by a European grant program and partially funded by the patent-holding company, which makes the research more objective than that of the boswellia extract.

An animal study on this chicken comb extract found similarly impressive results. Dogs with osteoarthritis who consumed this ingredient experienced “improvements in osteoarthritis biomarkers.”

Overall this appears to be an effective ingredient for joint pain, even though the research is early-stage.

The final ingredient in Arthrozene is another patented compound called “B-2Cool” and is Type II Native Collagen. The dose is quite low at only 40 mg.

We don’t believe this to be an effective ingredient dosage, as the patent holder’s website doesn’t appear to publish any medical research proving this ingredient alone is effective for joint pain at the 40 mg dosage.

There is one medical study showing that this collagen ingredient at a dosage of only 10 mg in combination with 1,500 mg of acetaminophen is effective for treating pain, but this isn’t an impressive or surprising result given that acetaminophen is the active ingredient in Tylenol and is one of the most widely-used pharmaceutical analgesics (pain-relievers) in the world.

It’s almost certainly the effects of acetaminophen and not the minute dosage of collagen causing the pain relief, which is why we feel this is a poorly designed study.

Overall this product is pretty well formulated, especially in comparison with other natural pain relief supplements we’ve reviewed previously like Relief Factor.

All three of the active ingredients appear to be effective for pain relief, and two of them appear to be effectively dosed.

It’s also worth noting that all of the inactive ingredients used in Arthrozene appear to be safe and non-toxic, which is not always the case with supplements.

No Published Test Results

Arthrozene doesn’t publish any test results, performed in-house or by a third-party, to prove that their product is accurately labeled (contains the listed ingredients at the listed dosages) and pure (contains low or undetectable levels of contaminants such as heavy metals and pesticides).

This issue isn’t unique to Arthrozene; very few supplement companies publish testing to prove their products are safe and effective (Bluebird Botanicals is one of the few that does).

We don’t recommend supplements from companies that don’t publish testing due to the serious contamination and mislabeling issues in the U.S. supplement market. In 2020 alone 800 individual supplement brands were ordered to remove all of their products from the market by the Food and Drug Administration (FDA) due to violations of good manufacturing practice.

Put simply, we believe that if you as a consumer can’t see independent test results proving that a dietary supplement contains the listed ingredients and low levels of contaminants, you have no reason to trust the company.

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Conclusion

Arthrozene is a decently formulated dietary supplement for joint pain. It is better-formulated than most supplements we’ve reviewed, given that all of its active ingredients work to positively impact the stated health claim, and two of them appear to be effectively dosed based on limited medical research.

We don’t recommend this product because one of the ingredients appears to be ineffectively dosed (or at the least there isn’t any data we could find proving it’s effective at the given dose), and because the company doesn’t publish any testing proving that their product is accurately labeled and as potent as advertised.

We think it’s a good thing that Arthrozene uses patented compounds, as these tend to have more research backing them and a more standardized effect profile. 

We don’t believe this formulation is harmful assuming it’s low in contaminants, and it may help for joint pain given its ingredients.

If Arthrozene publishes test results of their product in the future we will consider revising this review and recommending the product because of its formulation which is mostly backed by scientific research.





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