Acxion Review: Does the Mexican Drug Cause Weight Loss?

Acxion Review: Does the Mexican Drug Cause Weight Loss?

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Disclaimer: None of the information in this article constitutes medical advice, and is just the opinion of the writer(s). We recommend that patients follow their doctor’s guidance in regard to weight loss.

Acxion is the branded version of phentermine, and is sold as a prescription drug in Mexican and Spanish markets. The pills are used for weight loss, and the drug has a stimulant effect.

But is Acxion proven to cause weight loss in medical studies or is it a waste of money? Does the drug have the potential to cause serious side effects? How do real users rate and describe the effects of Acxion? And is the drug available over-the-counter (OTC) without a prescription?

In this article we’ll answer all of these questions and more as we analyze medical studies on Acxion to determine if the drug is likely to be effective for weight loss, and if it causes side effects.

We’ll feature Acxion customer reviews and explain if the drug is available OTC.

Does Acxion Cause Weight Loss?

Acxion is sold at three doses, but the most common are 15 milligrams (mg) daily and 30 mg daily.

As we documented in our phentermine weight loss reviews article, this drug has been clinically tested to determine its effects on weight loss.

A clinical trial published in the Yonsei Medical Journal found that Acxion caused over 90% of patients to lose 5% or more body weight over the course of 14 weeks.

It’s notable that the dose used in this trial was 37.5 mg, slightly higher than the maximum Acxion dose.

A 2013 medical review found that Acxsion caused a 9.3% body weight loss from baseline over the course of two years. The dose used in this trial was only 7.5 mg daily.

A medical review published in the Obesity journal found that weight loss outcomes in patients taking Acxion were superior in those taking the drug for longer than 3 months.

Based on the available research, we consider Acxion likely to be effective for weight loss.

But does the drug cause dangerous side effects? We’ll review in the next section.

Is Acxion Dangerous?

Given that Acxion is a stimulant drug, it does have the potential to cause side effects in some patients.

A medical review published in the LiverTox journal described the following side effects as “common:” nervousness, excitability, insomnia, headache, dry mouth, sweating, tachycardia, palpitations, nausea, constipation, and thirst.

The same review also described rare and severe side effects such as heart palpitations and high blood pressure.

A medical review published in the Obesity journal had an interesting and nuanced take on Acxion: that the metabolic benefits from weight loss in obese patients tend to outweigh the negative side effects of the drug such as increased blood pressure.

Essentially, normalizing weight can have favorable effects on blood pressure while Acxion may have negative effects on blood pressure, but the weight reduction effect tends to be more potent.

Based on the available research, we consider Acxion somewhat likely to cause side effects, and we would recommend that patients speak with their doctor about the risk of side effects prior to using this drug.

Real People Try Acxion

A YouTube creator named Claudia Rivera shared her results after using Acxion for 30 days including before-and-after images (remember that phentermine and Acxion contain the same active drug ingredient so they are functionally the same – Acxion is just the brand-name version):

A YouTube creator named "Hella Bella" shared her experience after one month of taking Acxion:

Is Acxion Available OTC?

Acxion does not appear to be available for prescription in the US, because we can’t find any drug label for the medication published by the FDA, or any other notice that it’s FDA approved.

A drug called Qsymia contains the same active ingredient as Acxion (phentermine) along with another active ingredient (topiramate), so patients in the US interested in Acxion may wish to speak to their doctor about this drug instead.

Acxion appears to be legal for prescription in Mexico but we cannot verify this from an official Mexican government website, only third-parties online, so patients in Mexico should speak with their doctor to confirm this drug’s legal status.

We cannot find any information suggesting that Acxion is available OTC either in the US or Mexico, so we urge patients to proceed with extreme caution and speak with a doctor before purchasing this drug from an online pharmacy.

Purchasing a drug that’s in a legal grey area from an unlicensed online pharmacy may dramatically increase the risk of fake or counterfeit product.

Are Diet Pills Dangerous?

A YouTube creator named “MissGreenEyes” shares her horrible experience taking diet pills and warns other people to avoid them:

Our Clean Weight Loss Picks

There are food-based nutrients which have been shown in medical studies to be effective for weight loss.

Dietary fiber was shown in a medical review published in The Journal of Nutrition to cause 16 pounds of weight loss in 6 months when combined with moderate caloric restriction (750 calories per day below baseline).

MBG Organic Fiber Potency+ is our top fiber pick because it's certified organic, provides 7 g of fiber per serving and costs under $1.85 per serving at the time of updating this article.

MCT oil was shown in a meta-study to cause more than one pound of weight loss over 10 weeks. This equates to potential annualized weight loss of 6 pounds per year with less than one tablespoon's worth of MCT oil per day.

Performance Lab MCT Oil is our top MCT oil pick because it's certified organic.

Ginger intake "significantly decreased body weight" according to a 2019 meta-study on ginger and weight loss that analyzed data from 14 clinical trials.

Pique La Ginger is our top ginger product, because it's an organic tea in convenient crystallized form, and all that's needed is to pour the powder into a glass and add hot water.

All three of the products mentioned in this section are entirely free of additive ingredients that we consider to be unhealthy.

Pros and Cons of Acxion

Here are the pros and cons of Acxion in our opinion:


  • Active drug ingredient clinically shown to be effective
  • Should cause weight loss
  • Real users have shared impressive weight loss results


  • Exists in legal grey area
  • Can’t confirm legality in US
  • Can’t confirm legality in Mexico
  • May cause severe side effects
  • Stimulant drug
  • Some unlicensed pharmacies appear to be selling it online
Stay up-to-date on our research reviews


The active ingredient in Acxion is well-studied, and seems to be effective for weight loss based on clinical trials.

This medication is a stimulant that can reduce appetite and food cravings, thereby reducing calories consumed.

One clinical trial found that even a low dose of Acxion caused nearly 10% body weight loss in two years.

Like most stimulant drugs, Acxion does have the risk of side effects, including nervousness and headache as more minor side effects and heart palpitations and high blood pressure as more severe side effects.

We strongly recommend against purchasing this drug from an online pharmacy because we cannot find clear evidence of its legality for OTC purchasing. Patients interested in this medication should speak about its availability with their doctor, or speak about FDA-approved alternatives like Qsymia (or natural, food-based supplements).

We hope that in the future, the Mexican government publishes clearer guidance about whether this drug is legal for prescription and for OTC use.