How to Lose Weight Fast: A Research-Based Analysis

How to Lose Weight Fast: A Research-Based Analysis


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Disclaimer: None of the information in this article constitutes medical advice. This article is the opinion of the writer(s), and is presented for informational purposes only. We recommend that patients follow their doctor’s guidance in regard to weight loss.

Obesity is an epidemic in the United States. According to Centers for Disease Control (CDC) data, 42.4% of adults in the U.S. are obese and an even higher percentage are overweight.

Given these numbers, many people are curious if there are research-backed strategies for losing weight fast. Gradual weight loss over time is typically considered more sustainable, but more rapid weight loss is possible over short periods. It tends to come with more risks.

In this article we’ll analyze published medical research on weight loss and explain several strategies to lose weight fast that have clinical backing.

Is Losing Weight Fast Possible?

Before examining individual strategies, it’s useful to see if it’s even possible to lose weight fast without medical intervention, and if so what degree of rapid weight loss is possible naturally.

A clinical trial published in the International Journal of Endocrinology Metabolism compared rapid weight loss to slow weight loss. Both groups were placed on a restricted-calorie diet, but the rapid weight loss group more severely restricted calroies. The rapid weight loss group was able to lose over 5% of their body weight in 5 weeks. 

The average weight at baseline in the rapid weight loss group was 188.5 pounds. The average weight at the end of the trial was 177 pounds. This equates to a 6% body weight loss in 5 weeks.

A separate weight loss trial from 2017 demonstrated that patients could lose around 10% of their body weight over the course of 46 days. The trial participants were placed on an extremely low-calorie diet.

Clearly it’s possible to lose weight fast with lifestyle interventions, and there may be no need for extreme or riskier measures like surgery.

Weight Loss Strategy #1: Intermittent Fasting

As we outlined in our DoFasting reviews article, intermittent fasting is proven to cause weight loss on average. This doesn’t mean that it will be effective for everyone; just that it will cause weight loss for most people if applied properly.

Intermittent fasting involves fasting for extended periods of the day (typically 16 hours), and then consuming the day’s worth of calories in a restricted window (typically 8 hours).

Intermittent fasting is effective because it has favorable effects on metabolism.

An extensive medical review was published in 2020 examining whether intermittent fasting is effective for weight loss. The study authors analyzed results from 27 individual medical trials on intermittent fasting and weight loss, and found that the participants lost weight on average in every single trial.

This is an incredible result, especially considering that the actual methods of intermittent fasting used in the trials varied. Some groups performed 16-hour daily fasts, some groups performed alternate day fasts, while others significantly reduced caloric intake on alternate days without totally fasting.

The average weight loss documented in this review ranged from 0.8% of body weight in the least effective trial, to 13% of body weight in the most effective trial. The trial lengths ranged from 2 to 26 weeks. 

The group that lost 13% of body weight was on a program that involved three days of fasting and four days of full caloric needs per week. The fasting days allowed for 25% of caloric needs.

Clearly intermittent fasting can be an effective strategy for some individuals to lose weight fast.

Weight Loss Strategy #2: Paleo Diet

We don’t generally recommend any specific diet model for overall health, but there is an interesting clinical trial involving the Paleo Diet and rapid weight loss.

The trial examined weight loss outcomes for Type-2 diabetic patients placed on a paleolithic (paleo) diet. This diet consists of foods that our hunter-gatherer ancestors would have consumed, and cuts out most agricultural products.

The trial participants were allowed to consume the following groups of foods: lean meat, fish, seafood, eggs, vegetables, fruits, berries and nuts.

The trial participants were disallowed from consuming the following groups of foods: cereals, dairy products, legumes, refined fats, refined sugars and added salt.

Fat mass decreased over 12 weeks by 12.57 pounds even without adding exercise, and by 14.77 pounds in the paleo group also engaging in exercise.

A separate meta-study which reviewed many different clinical trials on the Paleo Diet concluded that the diet has favorable effects on weight loss and waist circumference.

The Paleo Diet appears to be an effective approach for losing weight fast, especially for people starting from an unhealthy Standard American Diet (SAD) high in processed food.

Weight Loss Strategy #3: High-Intensity Interval Training

High-intensity interval training (HIIT) is a type of exercise that involves short bursts of work at nearly maximum capacity. It could include hill sprints or biking on a stationary bike at maximum resistance. These bursts, or “intervals,” are broken up by longer periods of moderate or low intensity.

This form of exercise has been found to be extremely effective for fat loss in medical research, but it’s important to note that it may be riskier for patients in poor physical condition than moderate exercise. We recommend that anyone considering high-intensity interval training to lose weight get this activity cleared by a doctor first, because it may not be safe for patients with high blood pressure or significant obesity.

A medical review was published in 2019 titled “Is interval training the magic bullet for fat loss?” 

The researchers found that high-intensity interval training caused 28.5% greater reductions in absolute fat mass than similar workouts at moderate intensity. Even though the calories burned may have been similar, HIIT appears to cause favorable metabolic changes that lead to greater fat loss over time.

One of the benefits of HIIT training over standard workouts is it’s more time-efficient. It's possible to be in and out of the gym in 25 minutes or so, because the workouts are more intense and rests between sets are shorter.

Our Weight Loss Supplement Recommendations

There are several weight loss supplements that we recommend due to their research backing and lack of side effects. 

These compounds can be used supplementally with one of the strategies listed above to potentially increase weight loss further.

Dietary fiber is a safe and effective weight loss supplement.

An extensive medical review published in The Journal of Nutrition found that dietary fiber intake directly predicts weight loss when consumed at a high enough dose. Fiber is zero-calorie plant matter that makes you feel full faster, and consume fewer calories overall.

The fiber supplement we recommend is SuperGut Fiber Mix. It contains a clean and effective formulation: a blend of three different types of unflavored dietary fiber and zero additive ingredients. It can be mixed into liquids or foods. Interested consumers can buy SuperGut fiber at this link.

We recommend using two fiber mixes per day, which provides 16 grams (g) of fiber. This is within the effective fiber dosing range associated with the greatest weight loss outcomes in the above-linked study.

Medium-chain triglyceride (MCT) oil is another dietary supplement which has been shown in clinical trials to cause weight loss.

MCT oil is quickly absorbed by the body and increases metabolic rate, which causes fat loss. A meta-study on MCT oil documented weight loss of 1.12 pounds over 10 weeks. This equates to a potential annualized weight loss of 5.84 pounds with MCT oil supplementation.

We recommend Bulletproof MCT Oil as our top MCT oil product, because it has a clean and effective formulation. The only ingredient is MCT oil derived from coconuts, and the product has no questionable additives. Interested consumers can buy Bulletproof MCT Oil at this link.

The effective dose range of MCT oil for weight loss (based on the medical review) is 1.7 g to 10 g per day. Bulletproof's MCT oil provides 14 g in one tablespoon, so around two-thirds of one tablespoon should be a maximally-effective dosage.

Men and Women Respond Differently to Rapid Weight Loss

One fact that many people aren’t aware of is that men and women respond differently to rapid weight loss from a physical perspective.

A medical study published in the Diabetes, Obesity and Metabolism journal analyzed results from 2,500 men and women on a restricted-calorie diet. They found that men tolerated the rapid weight loss approach better. Men had 16% greater weight loss on average, and greater reductions in markers of metabolic syndrome and heart rate.

Women had larger reductions in HDL (“healthy”) cholesterol levels, which isn’t necessarily a good sign.

The medical community hasn’t established why there would be a sex difference in rapid weight loss outcomes, but future research will hopefully emerge explaining (or counteracting) this data.

This early data suggests that men may be more likely to see favorable results from short-term “extreme” dieting (which we wouldn’t recommend for health reasons).

Why Rapid Weight Loss Isn't Optimal Long-Term

Most restricted-calorie diets fail in the long-term. It’s possible to cut weight for a few weeks or even a month based on sheer will power, but this often isn’t sustainable.

Medical research shows that around 80% of people who lose significant body fat through dieting regain the weight after 12 months.

Simply cutting calories on an unhealthy diet will often result in cravings. It’s not an intelligent strategy if no dietary modifications are made.

The average American eats processed and packaged food for a decent percentage of their overall caloric intake, and trying to just eat smaller portions doesn’t work for most people. The diet is too low in fiber and the caloric reduction becomes an hourly struggle to avoid temptation.

This is why we believe an approach based on dietary changes favoring more whole foods, exercise, and potentially weight loss supplements such as dietary fiber and MCT oil may lead to improved long-term weight loss compared to extreme dieting.

More Sustainable Alternative

Since we’ve established that cutting calories on the Standard American Diet and trying to starve yourself is an ineffective way to lose weight over time, the more effective approach is adding a significant amount of dietary fiber which reduces cravings.

A landmark medical study found that moderate caloric restriction (750 calories per day below baseline) combined with dietary fiber intake (a minimum of 20 grams per day) caused an average weight loss of 16.03 pounds over 6 months. That’s a pace of 32 pounds per year of weight loss in overweight individuals simply by adding fiber to a moderately-restricted-calorie diet.

Fiber is so effective for weight loss because it increases satiation (feeling of fullness), slows digestion and takes up space in the stomach. Differences in fiber content is the reason it’s relatively easy to eat a whole pizza that’s 2,000 calories in one sitting, but much more challenging to eat 2,000 calories of steak, beans and salad in one sitting.

Can I Lose Weight Fast Without Exercise?

While exercise is an important part of an overall healthy lifestyle, it’s not necessary to achieve successful long-term weight loss. The study linked in the previous section on dietary fiber intake had no exercise requirement.

Participants only reduced calories by 750 per day and consumed a minimum of 20 g of fiber per day.

Exercise burns calories, but it often increases hunger, so its effect on weight loss may not be as significant as dietary changes.

How to Lose Water Weight Fast?

If the goal is to reduce water weight, a low-carb diet is a logical solution. Carbohydrate intake increases glycogen storage, which consequently increases water storage in muscles, according to medical data.

Water weight can significantly influence overall weight, so switching from a high-carb to a low-carb diet can sometimes cause temporary weight loss of up to 10 pounds. It’s important to note that this isn’t true fat loss, and will likely be reversed if carb intake is increased.

We recommend that people speak with their doctor before making major shifts in their diet to reduce water weight. It’s not always the healthiest decision, especially if the shift is made rapidly without giving the body time to adjust, and losing fat should be the goal for overweight individuals; not losing water.

Can You Lose Weight on Metformin?

Overweight patients are often curious about the ability of Metformin, an anti-diabetic medication, to cause weight loss.

Metformin is only approved by the Food and Drug Administration (FDA) to treat type-2 diabetes, so using it for weight loss alone would be an off-label use that we wouldn’t recommend.

Metformin has been proven in a clinical trial to be effective as a standalone weight loss treatment for weight loss, so perhaps the FDA will approve it for weight loss in the future after more research confirms these findings. The study found that metformin supplementation at a dose of 2,500 milligrams (mg) per day caused an average weight loss of 12.79 pounds over 6 months.

We published an article titled "does Metformin cause weight loss" for readers interested in exploring this topic further.

Stay up-to-date on our research reviews

Conclusion

There exist research-backed methods of rapid weight loss. Intermittent fasting, paleolithic dieting and high-intensity interval training have all been shown in medical studies to cause significant weight loss in relatively short durations of time. Supplementation with dietary fiber and MCT oil may further enhance weight loss outcomes from these strategies.

These methods typically involve more risk to patients in poor health, so we recommend that anyone considering these rapid weight loss methods get a doctor’s clearance first.

Significantly increasing dietary fiber intake over 20 grams per day is the most sustainable long-term weight loss strategy in our opinion, and the one we typically recommend.

Fiber makes you feel full faster, which allows for increased adherence to diet with reduced discomfort like cravings.




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