Disclaimer: None of the information in this article constitutes medical advice, and is just the opinion of the writer(s) and published for informational purposes only. We recommend that patients suffering from nerve pain consult with a doctor about treatment.
Nerve Control 911 is one of the most popular dietary supplements for nerve pain and central nervous system (CNS) dysfunction. The product is manufactured by Phytage Labs and is described as a “Central Nervous System Protection Formula” that “reduces nervous system inflammation.”
In this article we’ll review the ingredients in Nerve Control 911 based on medical research to determine if it’s likely to be effective and safe for the stated health claims. We’ll also highlight some ethical issues we have with what Phytage Labs considers “clinical research” backing its supplement.
Misleading Clinical Research Section
On the Nerve Control 911 product page, there is a “View Clinical Research” button where the manufacturer shares some links to webpages to promote the efficacy of their product.
The term “clinical research” when used in a medical context describes studies published in medical journals evaluating the efficacy and/or safety of a compound. As an example, when a pharmaceutical drug manufacturer tests their product on patients versus placebo, that is clinical research.
Most of the links in the “Clinical Research” section on the Nerve Control 911 site are not, in fact, clinical research at all. Instead most are links to websites providing broad overviews of some of the ingredients in the formulation.
As a particularly ridiculous example, one of the links is to an Australian website called Plant Essentials which discusses herbs and potted plants.
This is not clinical research, and we find it to be misleading to indicate so.
Nerve Control 911 has a relatively simple formulation: it contains five active ingredients.
The first active ingredient, and the one at the highest dose, is passion flower at a dose of 145 milligrams (mg). Phytage Labs spells the botanical name of this herb wrong, which is a sign of incompetence. Its accurate botanical name is Passiflora incarnata, while it’s listed currently on their Supplement Facts label as Passiflora incarnate.
One medical trial found this herb to be effective for improving stress resistance and quality of life in adults, but the dose used was 425 mg and the researchers used a standardized extract, which is far more potent than the raw herb used in Nerve Control 911. A separate study found that tea made from this herb, which is presumably much lower-dosed, was effective for improving sleep quality in adults, so this ingredient is perhaps effectively dosed for sleep benefit.
Marshmallow root is the second active ingredient, and as we discussed in our review of Total Restore, this herb is typically used to treat cough and not for nervous system inflammation. Even the “Clinical Research” section on Nerve Control 911’s site doesn’t suggest this ingredient is effective for nervous system health. Instead it links to websites suggesting this ingredient aids mucosal swelling of the respiratory tract and for digestive and skin conditions. Thus we consider this an ineffective ingredient choice.
Corydalis is the third active ingredient in Nerve Control 911. Their website suggests this herb relieves pain naturally, and it does appear effective for that purpose based on medical research. However, the dosage in Nerve Control 911 may be significantly underdosed.
A medical review of corydalis published in the PLOS One journal found the following: “We show that YHS at 500 mg/kg displays a significant antinociceptive effect.” This review primarily analyzed animal studies, as there don’t appear to be many human studies on corydalis for pain.
Nerve Control 911 contains 100 mg of raw corydalis powder, which is less potent than corydalis extract, which is used in most of the medical research. A plant extract contains a higher potency of the active phytochemicals than the raw plant powder.
The average adult human weighs around 60 kg, so the dose found effective in the medical review was 30,000 mg of corydalis extract. This is a 300x higher dose than that in Nerve Control 911, and again this is an extract formulation which is already more potent. Thus we will conclude that the dosage in Nerve Control 911 is underdosed and likely ineffective.
The fourth-listed ingredient in Nerve Control 911 is a concentrate of prickly pear, which is harvested from cactus. An interesting medical trial proved the anti-inflammatory effects of this botanical compound in healthy human participants. Those taking prickly pear juice had decreased pro-inflammatory biomarkers and increased anti-inflammatory biomarkers.
The dose used in the medical study was 200 grams (g), which equates to 200,000 mg. The dose in Nerve Control 911 is 50 mg of a 20:1 concentrate, which equates to 1,000 mg. So the dose used in the medical study was 200x higher than the dose used in Nerve Control 911. We will consider this an ineffective dose.
The final active ingredient in Nerve Control 911 is 50 mg of California poppy seed. The minimum dose of this herb used in either of the medical studies cited on Nerve Control 911’s “Clinical Research” section was 25 mg/kg, from this animal study. For an average human that’s 1,500 mg, which is 30x the dose in the supplement. Thus, we will conclude that this ingredient is underdosed and likely ineffective.
One beneficial aspect of Nerve Control 911 is that the excipient (filler) ingredients the brand uses for the capsule and other effects are non-toxic and safe, which isn’t always the case. There are no added sugars or natural flavors which is a plus.
Overall we find this to be a relatively poor formulation due to what we consider to be several underdosed ingredients. Most of the ingredients do have research backing, but we believe many of them are dosed far too low. We believe their passion flower is the only effectively-dosed ingredient based on published medical research.
Why We Don’t Recommend Nervous System Supplements
In many of our reviews, if we don’t find the formulation likely to be effective, we’ll offer what we believe to be safer and more effective alternatives. In this case we won’t because we don’t recommend nervous system supplements.
While we believe there is sufficient medical evidence to recommend supplements for certain downstream effects of nervous system dysfunction, such as sleep loss or anxiety, we don’t believe it’s logical to take a supplement for general “nervous system protection.”
The nervous system is incredibly complex and even the top researchers and doctors haven’t identified compounds that can holistically optimize and treat nervous system dysfunction. Thus we find it very unlikely that patients will experience these results from a supplement available for purchase online.
No Public Team
Phytage Labs’ About Us page on their website doesn’t detail any specific team member. Rather, it provides generic information about the company’s mission and value proposition. We consider this a red flag of a low-quality supplement brand.
We believe that supplement companies should be eager to share information about their founders and the scientists or researchers on their team if they’re proud of the products they’re developing. If the owner of a company doesn’t even want to publicly associate with their brand, do you really want to take their products?
We typically recommend that consumers only purchase supplements from companies that identify medical experts and/or researchers associated with their formulations. It’s not easy to formulate an effective supplement based on medical data, and those without credentials aren’t likely to be able to do so.
We also find it strange and misleading that Phytage Labs claims on their about page that all of their health supplements feature “organic ingredients.” According to their own Supplement Facts label for Nerve Control 911, not a single one of the ingredients is organic.
Nerve Control 911 User Reviews
Nerve Control has a 3.6 out of 5 star rating on Amazon, which we believe is a more legitimate source of reviews than company website reviews. This is a relatively low rating.
Of the 869 total reviews, 402 are 5-star reviews. The top-rated positive review comes from a user who made a verified purchase named “Shirley Horton.” Her review is strangely negative for a 5-star review:
“This product is working but its too expensive and Im 74 years old and on a fixed income”.
The top-rated negative review is written by a reviewer named “Robert J” and claims that the product had no positive effects on his nerve condition:
“I have idiopathic polyneuropathy. I tried this product for a month and did not experience any improvement. The company indicated that there should be noticeable improvement in 7 days. This was not my experience.”
Nerve Control 911 receives a B grade from FakeSpot, an Amazon review algorithm that detects likely fake reviews. This is a good sign that the brand likely hasn’t falsified any reviews.
Nerve Control 911 Pros and Cons
Here’s our take on the pros and cons of this product:
- Most ingredients have some research backing
- No harmful filler ingredients
- Passion flower appears effectively dosed
- Questionable health claims
- Unimpressive user reviews
- Most ingredients appear underdosed
- Misleading “Clinical Research” section on website
- No public team