Mitopure is a novel supplement from a company called Timeline that contains a compound called Urolithin A. The brand describes this supplement as "The first clinically tested Urolithin A supplement," and claims that it "energizes cells."

But is Urolithin A shown in clinical research to increase energy? What were the results of the clinical trials on Mitopure? Does this supplement contain any unhealthy ingredients? And is Mitopure better or worse than popular energy supplements like 5-Hour Energy?

In this article we'll answer all of these questions and more, as we analyze the ingredients in Mitopure to give our take on whether or not it's likely to be effective for improving energy, and whether or not it's healthy. 

We'll also analyze the clinical trials on Mitopure, and compare the supplement to other popular energy brands to pick our winners.

Key takeaways:

• Clinically shown to improve energy & strength in older adults
• No unhealthy ingredients
• We do not currently recommend Mitopure

Is Mitopure Proven to Work?

Timeline funded a clinical trial on Mitopure in older adults, published in the Nutrition, Obesity and Exercise journal.

Supplementation with the active ingredient in Mitopure (at twice the dose) caused a "significant improvement in muscle endurance" and decreased C-reactive protein levels (an inflammatory marker).

A 2022 clinical trial tested the exercise effects of Mitopure in middle-aged adults.

Leg strength and flexion were improved by around 15% in the group supplementing with Mitopure.

This trial showed the Urolithin A dose used in Mitopure to be effective (whereas the previous trial used double the dose).

At the time of publishing this article, there don't appear to be any other clinical trials on Mitopure with human participants published in peer-reviewed journals.

Overall, we consider Mitopure likely to be effective for improving exercise strength and endurance in middle-aged and older adults, however we have no evidence that it improves subjective energy levels.

Ingredient Analysis

The active ingredient in Mitopure is shown below:

As we established in the previous section, Urolithin A is clinically shown to have ergogenic (exercise-enhancing) effects in older adults both at a 500 milligram (mg) dose and a 1,000 mg dose.

The inactive ingredients in Mitopure are shown below:

These ingredients should be safe and non-toxic.

Overall, we consider Mitopure to be effectively dosed, and we consider it to have no unhealthy additives.

Does Mitopure Cause Side Effects?

Mitopure appears to have a favorable side effect profile according to the clinical trials we cited previously in this article.

The first trial reported "no statistical differences in adverse events" between the group taking placebo pills and the group taking Mitopure.

In the second trial, the placebo group reported more adverse events, which suggests that Mitopure doesn't cause any significant side effects.

A medical review on Urolithin A, published in the Nutrients journal, didn't report any side effects.

Overall, we consider Mitopure unlikely to cause side effects in healthy adults.

Mitopure vs. Popular Energy Supps

Here's how Mitopure compares to other popular energy supplements in terms of formulation quality and healthiness, in our opinion:

5-Hour Energy

More likely to improve energy levels due to caffeine dose, but extremely unhealthy formulation.

Contains an artificial sweetener clinically shown to cause negative changes to insulin function, synthetic preservatives, and an active ingredient combination which can increase blood pressure beyond caffeine alone.

Winner: Mitopure

G Fuel

One of the most popular energy supplements with younger generations, G Fuel is glorified, flavored caffeine.

Unhealthy formulation that contains artificial flavors, artificial food dye and at least one vitamin additive clinically associated with increased mortality, as we documented in our G Fuel review article.

Winner: Mitopure

Energy Renew

Contains at least two research-backed active ingredients, but contains two inactive ingredients that we consider unhealthy, giving Mitopure the edge from a health perspective.

Winner: Mitopure

Our Clean Energy Picks

Illuminate Labs Panax Ginseng Extract is our top energy supplement.

Panax ginseng extract has been clinically shown to reduce mental fatigue and reduce physical fatigue, and our supplement is third-party tested to ensure its purity and potency.

Pique Breakfast Black Tea Sticks is our top whole food energy pick.

Black tea consumption is "associated with rapid increases in alertness and information processing capacity" according to a clinical trial, and Pique's tea is organic and comes in convenient stick packs that can be mixed into water, so a teapot or kettle are not needed.

Both of the products recommended in this section are free of ingredients we consider to be unhealthy.

Mitopure Pros and Cons

Here are the pros and cons of Mitopure in our opinion:

Pros:

• Clinically tested
• May improve strength in older adults
• May improve endurance in older adults
• Unlikely to cause side effects
• No unhealthy additives
• Great branding
• Free shipping from brand's website
• Positive Amazon reviews

Cons:

• Mediocre Facebook reviews
• We can't find evidence of benefit in younger adults
• We can't find evidence for subjective energy improvements

Conclusion

Mitopure is a high-quality supplement brand in our view.

Its manufacturer, Timeline Nutrition, funded clinical trials published in peer-reviewed journals, which is uncommon for dietary supplements, and which is the gold standard for product research.

The trials found that Mitopure has ergogenic effects in middle-aged and older adults.

We do not currently recommend Mitopure because we don't consider it to be a particularly cost-efficient way to achieve these outcomes, but we have no issues with the supplement.

We're unable to identify any clinical trials showing that Mitopure is beneficial in individuals under the age of 40.

We do not consider Mitopure likely to cause side effects, as no greater rate of side effect reporting was seen in the Mitopure group compared to the placebo group in the trials.

The inactive ingredients in Mitopure should be safe and non-toxic, and there are no ingredients in this formulation that we consider to be dangerous or unhealthy.

We consider Mitopure to be a healthier option than other popular energy supplements like 5-Hour Energy, G Fuel and Energy Renew.