Skinesa Review: Can Probiotics Improve Skin?

Skinesa Review: Can Probiotics Improve Skin?

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Skinesa is a probiotic brand that's used to promote skin health. The brand describes its supplement as "a breakthrough from over a decade of research."

But does Skinesa contain research-backed ingredients for supporting skin health? Does the brand contain any questionable additive ingredients? How do real users rate and describe its effects? And is Skinesa clinically proven to work?

In this article we'll answer all of these questions and more, as we analyze the ingredients in Skinesa based on clinical studies to give our take on whether or not the supplement is likely to be effective for optimizing skin health.

We'll share our concerns with some of Skinesa's marketing claims, and feature unsponsored customer reviews of the brand.

Ingredient Analysis

Skinesa active ingredients

The active ingredients in Skinesa are shown above.

This is a probiotic blend with two relatively common probiotic species: Bifidobacterium and Lactobacillus.

One of the clinical trials cited by Skinesa shows that three of the probiotic strains used in this supplement improved skin health in participants with atopic dermatitis.

However, the doses used in the trial are different to the doses used by Skinesa, and this result is limited to a patient population with dermatitis; it doesn't necessarily suggest similar effect will occur in an individual without dermatitis.

A 2019 clinical trial cited by Skinsea reported that three of the probiotic strains used in this supplement improved skin health in participants with plaque psoriasis.

Improved gut health may be a secondary benefit of Skinsea, because this total probiotic dose is within the effective maintenance range, as we documented in our review of another probiotic supplement called Physician's Choice.

The inactive ingredients in Skinsea should be safe and non-toxic:

Skinsea inactive ingredients

Overall, we consider this formulation to be healthy, and to be somewhat likely to improve skin quality in individuals with dermatitis and psoriasis.

We haven't come across any convincing evidence that this formulation will improve skin quality in individuals without these conditions.

Questionable Marketing Claims

Skinesa questionable marketing claim 1

As shown above, the Shop page on Skinesa's website claims the product will improve the look and feel of skin within 90 days.

We don't know how the brand can make such a specific claim when it doesn't appear that the proprietary formulation of Skinesa has been studied.

Skinesa questionable marketing claim 2

Skinesa suggests on the Breakthrough page of their website that the supplement is "clinically proven" and that 90% of patients achieved healthy skin.

Some of the individual active ingredients in Skinesa are clinically shown to be effective in clinical studies. This is not the same as the supplement itself being clinically proven to work, and this distinction is not made clear in our opinion in the above marketing claim.

The clinical trial cited above was not completed using Skinesa, but on a formulation including some of the active ingredients in Skinesa.

Skinesa questionable health claim 3

The brand also claims, without any citation at the time of publishing this article, that 0.2% of probiotics are backed by any scientific evidence.

We strongly disagree with this claim, as more than 50% of the probiotics that we've reviewed to date on Illuminate Health were backed by at least some existing scientific evidence.

Real People Try Skinesa

A YouTube creator named Rob Stuart claims to have experienced positive results from Skinesa:

A TikTok creator named Lauren Du Pree claims to have experienced some flare-ups from Skinesa:

@dupreezy Happy TSW Awareness Day! Didn’t even know that was a thing til this morning. Anyways, I’ve been using Skinesa for 90 days and I have improved, but there’s still much to be desired. #tsw #topicalsteroidwithdrawal #healing #skinesa #fyp ♬ original sound - Lauren Du Pree

Will Skinesa Cause Side Effects?

Skinesa doesn't appear to have been studied in any clinical trials, which makes it challenging to determine whether or not the supplement will cause side effects.

However, we can make an educated guess based on its ingredients.

The total probiotic dose is well within the standard daily dosing range according to a Probiotic Fact Sheet published by the National Institutes of Health.

This is important, because high doses of probiotics can cause temporary digestive issues like gas and bloating, as we discussed in our BioFit reviews article on another probiotic supplement.

We do not consider Skinesa likely to cause side effects in otherwise healthy individuals based on its ingredients.

There are no ingredients in this supplement that we consider to be unsafe.

The brand's website claims that there are "no known side effects" at the time of publishing this article.

Dermatologist on Probiotics and Skin

A board-certified dermatologist and popular YouTube creator named "Dr Dray" has a video on probiotics and skin:

Our Clean Skincare Picks

There are skincare products containing ingredients shown in clinical trials to be effective for reducing wrinkles and improving skin quality.

Annie Mak Vitamin C Serum is our top anti-aging serum.

It contains hyaluronic acid which was described as a "skin-rejuvenating biomedicine" in a medical review due to its ability to reduce wrinkles and signs of facial aging.

Momentous Collagen Powder is our top skin supplement.

Collagen supplementation was shown in a medical review published in the Journal of Drugs in Dermatology to reduce visible signs of skin aging as well as improve skin elasticity and skin hydration.

HYDRAGLOW by CLEARSTEM is our top moisturizer pick.

It features bakuchiol as an active ingredient which was described in a 2014 clinical trial as "clinically proven to have anti-aging effects."

All of the products recommended in this section are entirely free of ingredients that we consider to be unhealthy.

Skinesa Pros and Cons

Here are the pros and cons of Skinesa in our opinion:


  • Healthy formulation
  • Likely to improve skin in patients with dermatitis
  • Likely to improve skin in patients with psoriasis
  • May have secondary benefits to gut health
  • Mostly positive online customer reviews
  • Unlikely to cause side effects


  • Proprietary formulation doesn't appear to be clinically tested
  • Brand makes some questionable marketing claims
  • Some active ingredients have different doses than the existing clinical studies cited by the brand
Stay up-to-date on our research reviews


We think that Skinesa is worth discussing with a dermatologist for individuals with dermatitis and psoriasis. 

We're entirely unconvinced that this supplement improves skin quality in otherwise healthy individuals, but it's primarily formulated with probiotics so it may benefit gut health regardless.

We're eager to witness the continued development of the probiotic market, because probiotics have wide-ranging potential therapeutic applications that can improve human health.

Skinesa makes some marketing claims on their website that are confusing to us. Some of the language on the website makes it seems as though the supplement is clinically tested, when that doesn't appear to be the case.

Rather, some of the supplement's active ingredients appear to have been clinically tested in existing trials. We think the brand could do a better job making that differentiation clear.

Most of the online customer reviews that we came across while researching this article were positive.

Skinesa doesn't appear to be likely to cause side effects.