SciatiEase Review: Best-Formulated Nerve Health Supplement?

SciatiEase Review: Best-Formulated Nerve Health Supplement?

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SciatiEase is a dietary supplement used to support optimal nerve health. The brand claims that their product "supports daily comfort" and "supports healthy inflammatory response."

But does SciatiEase contain research-backed ingredients for nerve health, or are these just marketing claims? Does it contain any questionable additive ingredients? How do real users rate and describe the effects of SciatiEase? And which retailer sells this supplement for the best price?

In this article we'll answer all of these questions and more, as we analyze the ingredients in SciatiEase based on clinical studies to give our take on whether or not this supplement is likely to support optimal nerve health and reduce nerve pain.

We'll feature unsponsored customer reviews, and provide a cost comparison to show which retailer sells this supplement for the best price.

Ingredient Analysis

SciatiEase ingredients

The ingredients in SciatiEase are shown above.

B vitamins are associated with optimal nerve health, according to a 2021 medical review, but we can't find any clinical evidence that supplemental B vitamins are useful for nerve health in individuals without deficiencies in those vitamins.

Alpha lipoic acid "may result in some neuropathic symptomatic reduction" in diabetic patients with neuropathy according to a meta-study published in the Cureus journal.

This suggests that this compound may support nerve regeneration under some conditions.

Palmitoylethanolamide is clinically shown to reduce inflammation in a wide variety of nerve pain disorders, including sciatic pain, osteoarthritis, neuropathic pain and more according to a medical review published in the Journal of Pain Research.

Acetyl-l-carnitine supports nerve regeneration according to a 2005 clinical trial.

Feverfew is a plant with documented anti-inflammatory properties.

There is more research backing for the active ingredients in SciatiEase, but for the sake of brevity, we'll conclude by making it clear that this formulation has significant research backing.

The inactive ingredients in SciatiEase should be safe and non-toxic, and there are no ingredients in this formulation that we consider to be unsafe in otherwise healthy individuals.

Overall, we consider SciatiEase to be one of the best-formulated nerve health and pain relief supplements that we've reviewed to date on Illuminate Health, and we believe this supplement can support optimal nerve health.

Does SciatiEase Cause Side Effects?

SciatiEase doesn't appear to have been studied in any clinical trials, which makes it more challenging to determine whether or not the supplement will cause side effects.

However, we can make an educated guess based on its ingredients.

Alpha lipoic acid can cause side effects such as skin disorders, gastrointestinal disorders and even insulin autoimmune syndrome, according to a 2021 observational study.

This study was population-based and the serious side effects were very rare.

Chinese skullcap "may have adverse effects on the liver" according to LiverTox, although this seems unlikely at the dose in SciatiEase.

The SciatiEase website reports that all of the ingredients inside of SciatiEase are "safe, natural and haven’t been shown to have any significant side effects.” 

Can Stretches Relieve Sciatic Pain?

A YouTube video from Wellstar Health System has over 45,000 views and features some stretches that may relieve sciatic pain:

Where to Get the Best Price

 SciatiEase is sold at a variety of online retailers. Here's a price breakdown for a one-time purchase at the time of publishing this article:

Walmart: $84 (third-party seller, link)

Brand website: $69 (plus $6.95 shipping, link)

Amazon: $69.99 (free shipping, link to official Amazon listing)

SciatiEase is currently 8% cheaper on Amazon than on the brand's website for a one-time purchase, when factoring in shipping fees.

Real Customers Review SciatiEase

Amazon is a better resource for honest customer reviews than a brand's website in our opinion.

SciatiEase has been reviewed over 1,300 times on Amazon, with an average review rating of 3.5 out of 5 stars at the time of publishing this article.

The top positive review from a verified purchaser is written by a user named "P" who gives the product a 5/5 star rating and claims it relieved joint pain:

"I know its health benefits. My joints definitely feel better, so I know this product is doing its job. Delivery time was good, earlier than stated. I will definitely use this seller again. Definitely recommended."

The top negative review from a verified purchaser comes from a user named "jill sutton" who gives the product a 1/5 star review and claims to have experienced side effects:

"I was hoping that this would help me, but it made me violently sick. And all I took was one pill one time with food. I puked for hours and abdominal pain for hours. I would never recommend this product for anybody. It was horrible. I threw up six hours."

While the average Amazon review rating is somewhat mediocre, it's important to keep in mind that customers of an inflammation supplement are likely in greater pain than customers of a more generic supplement like protein powder, and may be more likely to leave negative reviews.

SciatiEase Labs (the manufacturer of SciatiEase) has responded to all customer complaints on the Better Business Bureau (BBB) site at the time of publishing this article, which is a sign of a high-quality brand.

Pros and Cons of SciatiEase

Here are the pros and cons of SciatiEase in our opinion:


  • Many research-backed active ingredients
  • Should support nerve health
  • May reduce nerve pain
  • Some proven anti-inflammatory ingredients
  • No unhealthy additives
  • Brand avoids making uncited health claims
  • Brand avoids pain relief claims


  • Brand website charges for shipping
  • Challenging to find customer reviews on YouTube or TikTok
Stay up-to-date on our research reviews


SciatiEase is a high-quality supplement in the nerve health and pain relief category.

This is one of the better-formulated supplements that we've reviewed to date on Illuminate Health.

Many of the active ingredients in SciatiEase have significant clinical backing, and there are no unhealthy inactive ingredients.

Palmitoylethanolamide in particular appears to be a promising compound for individuals with nerve disorders or pain.

Stretches may relieve sciatic pain, and seem like a good option for patients with this condition to consider, given that stretching is free and has minimal downside risk.

We do not consider SciatiEase likely to cause side effects in otherwise healthy individuals, although alpha lipoic acid may cause side effects in some individuals sensitive to this compound.

At the time of publishing this article, Amazon has a better price on SciatiEase than the brand's website when factoring in shipping fees.