OxyShred is a weight loss supplement sold by a brand called EHPlabs. The brand describes the supplement as a “thermogenic fat burner” and claims that it’s scientifically proven to work.

But is OxyShred actually proven to work? Does it contain any unhealthy ingredients? Is the brand's energy drink well-formulated? And is OxyShred better or worse than popular weight loss supplements like Obvi Collagenic Burn?

In this article we’ll answer all of these questions and more, as we analyze the clinical study on OxyShred to see if the supplement is actually proven to work.

We’ll also analyze the ingredients in OxyShred's weight loss supplement and energy drink to give our take on whether or not they're well-formulated, and compare OxyShred to other popular weight loss supplements to pick our winners (and losers).

Key takeaways:

• Shown to cause weight loss in a legitimate clinical trial
• Contains inactive ingredients we consider unhealthy
• We do not currently recommend OxyShred

Is OxyShred Proven to Work?

EHPlabs claims that OxyShred is scientifically studied, and to the credit of the brand, the supplement was studied in a clinical trial published in a peer-reviewed medical journal called the Journal of the International Society of Sports Nutrition.

Clinical trials published in peer-reviewed journals are the gold standard of product research.

This trial evaluated whether OxyShred could increase energy expenditure at rest.

OxyShred was found to increase resting energy expenditure, which means the supplement does increase fat burning at rest, but the effect was relatively modest.

Resting energy expenditure was increased in the OxyShred group from 121 calories to 166 calories per day.

According to the Mayo Clinic, one pound of weight equates to 3,500 calories. This means that OxyShred should cause 1 pound of weight loss after 78 days of use.

This still equates to around 5 potential pounds of weight loss per year.

Based on the clinical trial, we consider OxyShred likely to be effective for weight loss.

Ingredient Analysis

OxyShred contains a large number of active ingredients, but we want to focus our analysis on the Fat Burning Matrix, shown below, which contains the ingredients used to support the weight loss effect:

Garcinia cambogia fruit extract was shown in a medical review published in the Journal of Obesity to cause weight loss, but the doses used in most of the trials were more than 5x the average ingredient dose in OxyShred’s prop blend.

Conjugated linoleic acid is clinically shown to cause weight loss, but as we documented in our review of Night Shred, it’s also clinically shown to cause insulin resistance and oxidative stress at the dose required to cause weight loss.

Chromium is a mineral shown to cause an average of around 1 pound of weight loss in a medical review, but it may be unsafe to take minerals for extended periods of time without a deficiency in that mineral.

Coffee bean extract was shown in a meta-study published in the Phytomedicine journal to cause slightly over 1 pound of weight loss over eight weeks.

The inactive ingredients for the Guava Paradise flavor of OxyShred are shown below:

All of the flavors of this supplement contain similar ingredients.

Natural flavor is a broad categorical term that fails to describe the specific flavoring ingredients used. A 2013 medical review suggested that some flavoring ingredients and their metabolites may have toxic effects.

Citric acid is a preservative and flavor enhancer shown in a medical review published in the Toxicology Reports journal to cause whole-body inflammation in some individuals.

Sucralose is an artificial sweetener shown in a clinical trial to cause negative changes to insulin function, as we referenced in our Feel Great System reviews article on another weight loss brand that uses this ingredient.

Overall, we consider OxyShred likely to support weight loss, but we do not currently recommend this supplement due to the inactive ingredients highlighted above.

OxyShred vs. Popular Weight Loss Supps

Here's how OxyShred compares to other popular weight loss supplements in terms of formulation quality, in our opinion:

Obvi Collagenic Burn

Both supplements contain research-backed active ingredients, so we consider them equivalent from a potential efficacy perspective.

Obvi's supplement has a more unhealthy formulation, including a colorant which is banned in the EU over toxicity concerns. 

Winner: OxyShred

Phenocal

Phenocal is a weight loss supplement that contains an active ingredient clinically shown to cause liver injury in some cases.

OxyShred is the safer choice.

Winner: OxyShred

BurnXT

Contains green tea extract and lacks the clinical backing of OxyShred.

Winner: OxyShred

Is the Energy Drink Better-Formulated?

OxyShred recently released an energy drink, called OxyShred Energy.

Its ingredients are shown below:

Caffeine is the core active ingredient, and it's included at a high dose of around 340 milligrams (mg) per can.

This is equivalent to the caffeine content in over three regular cups of coffee.

There are a number of inactive ingredients in this formulation we consider unhealthy, including artificial sweeteners, green tea extract at an unspecified dose and a synthetic preservative.

We consider OxyShred Energy Drink's formulation to be significantly worse than the brand's weight loss supplement, and we do not currently recommend it for health reasons.

Our Clean Weight Loss Picks

Ceylon cinnamon was described as "an effective anti-obesity agent" in a 2022 meta-analysis. The study authors concluded that effects were greater at doses at or over 3 grams daily.

Illuminate Labs Ceylon Cinnamon Extract is our standardized Ceylon cinnamon supplement which is third-party tested to ensure purity and potency.

Dietary fiber was shown in a medical review published in The Journal of Nutrition to cause 16 pounds of weight loss in 6 months when combined with moderate caloric restriction (750 calories per day below baseline).

MBG Organic Fiber Potency+ is our top fiber pick because it's certified organic, provides 7 g of fiber per serving and costs under $1.85 per serving at the time of updating this article.

Both of the products mentioned in this section are free of ingredients that we consider to be unhealthy.

OxyShred Pros and Cons

Pros:

• Clinically shown to cause weight loss
• No dangerous stimulants
• Should cause weight loss
• Many research-backed ingredients
• Better formulation than competitors

Cons:

• Contains flavoring ingredients
• Contains citric acid
• Contains artificial sweetener
• Energy Drink contains unhealthy ingredients

Conclusion

OxyShred is a weight loss supplement that’s significantly better-formulated than the category average in our opinion.

This supplement is clinically shown to cause weight loss, and is one of very few weight loss supplements we’ve reviewed on Illuminate Health that’s been tested in a legitimate peer-reviewed medical journal.

Not only is OxyShred clinically shown to be effective, but it also contains a number of research-backed active ingredients.

We don’t currently recommend this supplement due to the inclusion of several inactive ingredients like citric acid and sucralose shown to have questionable health effects.

This brand recently released an energy drink, and we consider its formulation to be unhealthy.

We consider OxyShred's weight loss supplement to be a healthier option than weight loss supplements Obvi Collagenic Burn, Phenocal and BurnXT.