Arthrozene is a supplement for joint pain. It claims to provide pain relief and increase flexibility and mobility. The brand also has potentially the worst bottle design we’ve ever seen for a supplement but that’s another issue.
In this article we’ll review the ingredients in Arthrozene based on medical research to determine if it’s likely to be effective.
Arthrozene only has three active ingredients: boswellia serrata extract, chicken comb extract and collagen.
Boswellia serrata extract is an herbal extract sourced from a tree native to the Arabian peninsula. The dosage in Arthrozene of 100 milligrams (mg) may be effective for arthritis pain.
A clinical trial on this ingredient at the 100 mg dosage found that it was significantly more effective than placebo at reducing pain and improving joint function. It’s important to note that this study was funded by the company that manufactures the patented boswellia compound used in Arthrozene, so there is significant bias inherent in this study.
We recommend considering the results of company-sponsored research as somewhat useful but less trustworthy than independent research.
The website of the patent holder of the boswellia extract references two scientific studies proving it works, but we can only find one unique clinical trial; the one linked to above. The other publication appears to be simply a review of the previous trial with some further descriptions of the biological mechanisms involved.
So if there is only one company-sponsored study proving this ingredient is effective for arthritis pain, we would consider that weak evidence overall (though definitely better than nothing).
80 mg of natural chicken comb extract is the second ingredient in this supplement, and a patented extract called “Mobilee” is used. This extract has been tested in medical research and proven to be effective for pain reduction.
A clinical trial on healthy volunteers with joint irritation compared Mobilee with a placebo for pain management. The group taking Mobilee had significant pain reduction. The dosage used in the study is the exact same as that in Arthrozene.
The above-linked study was partially funded by a European grant program and partially funded by the patent-holding company, which makes the research more objective than that of the boswellia extract.
An animal study on this chicken comb extract found similarly impressive results. Dogs with osteoarthritis who consumed this ingredient experienced “improvements in osteoarthritis biomarkers.”
Overall this appears to be an effective ingredient for joint pain, even though the research is early-stage.
The final ingredient in Arthrozene is another patented compound called “B-2Cool” and is Type II Native Collagen. The dose is quite low at only 40 mg.
We don’t believe this to be an effective ingredient dosage, as the patent holder’s website doesn’t appear to publish any medical research proving this ingredient alone is effective for joint pain at the 40 mg dosage.
There is one medical study showing that this collagen ingredient at a dosage of only 10 mg in combination with 1,500 mg of acetaminophen is effective for treating pain, but this isn’t an impressive or surprising result given that acetaminophen is the active ingredient in Tylenol and is one of the most widely-used pharmaceutical analgesics (pain-relievers) in the world.
It’s almost certainly the effects of acetaminophen and not the minute dosage of collagen causing the pain relief, which is why we feel this is a poorly designed study.
Overall this product is pretty well formulated, especially in comparison with other natural pain relief supplements we’ve reviewed previously like Relief Factor.
All three of the active ingredients appear to be effective for pain relief, and two of them appear to be effectively dosed.
It’s also worth noting that all of the inactive ingredients used in Arthrozene appear to be safe and non-toxic, which is not always the case with supplements.
No Published Test Results
Arthrozene doesn’t publish any test results, performed in-house or by a third-party, to prove that their product is accurately labeled (contains the listed ingredients at the listed dosages) and pure (contains low or undetectable levels of contaminants such as heavy metals and pesticides).
This issue isn’t unique to Arthrozene; very few supplement companies publish testing to prove their products are safe and effective (Bluebird Botanicals is one of the few that does).
We don’t recommend supplements from companies that don’t publish testing due to the serious contamination and mislabeling issues in the U.S. supplement market. In 2020 alone 800 individual supplement brands were ordered to remove all of their products from the market by the Food and Drug Administration (FDA) due to violations of good manufacturing practice.
Put simply, we believe that if you as a consumer can’t see independent test results proving that a dietary supplement contains the listed ingredients and low levels of contaminants, you have no reason to trust the company.