{"id":605458956594,"title":"Equelle Review: Most Effective Menopause Supplement?","created_at":"2023-05-27T11:42:55-04:00","body_html":"\u003cscript type=\"application\/ld+json\"\u003e\/\/ \u003c![CDATA[\n{\n \"@context\": \"https:\/\/schema.org\",\n \"@type\": \"Article\",\n \"headline\": \"Equelle Review: Most Effective Menopause Supplement?\",\n \"keywords\": \"equelle, equelle review, equelle reviews, equelle side effects, equelle amazon, equelle ingredients, equelle supplement, equelle menopause\",\n \"description\": \"Our research team analyzes the ingredients in Equelle based on medical studies to give our take on whether the supplement is likely to be effective for relieving menopause symptoms or if it's a waste of money. We feature real customer reviews.\",\n \"url\": \"https:\/\/illuminatelabs.org\/blogs\/health\/equelle-review\",\n\"author\": {\n \"@type\": \"Person\",\n \"name\": \"Calloway Cook\",\n \"url\": \"https:\/\/illuminatelabs.org\/pages\/calloway-cook\",\n \"sameAs\": \"https:\/\/www.linkedin.com\/in\/calloway-cook\/\",\n \"jobTitle\": \"President\",\n \"knowsAbout\": \"entrepreneurship, dietary supplements, herbal supplements, eCommerce, medical research\",\n \"alumniOf\": {\n \"@type\": \"EducationalOrganization\",\n \"name\": \"S.I. Newhouse School of Public Communications at Syracuse University\"\n },\n \"memberOf\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n }\n},\n\"editor\": {\n \"@type\": \"Person\",\n \"name\": \"Auren Weinberg\",\n \"honorificSuffix\": \"M.D.\",\n \"url\": \"https:\/\/illuminatelabs.org\/pages\/auren-weinberg\",\n \"sameAs\": \"https:\/\/www.linkedin.com\/in\/aurenweinberg\/\",\n \"jobTitle\": \"Medical Reviewer\",\n \"knowsAbout\": \"pharmaceutical medication, medicine, OTC drugs, medical research, clinical trials, generic drugs, branded drugs, dietary supplements, chemistry, health, wellness, healthcare\",\n \"alumniOf\": {\n \"@type\": \"EducationalOrganization\",\n \"name\": [\n \"Haverford College\",\n \"University of Rochester School of Medicine and Dentistry\",\n \"Fox School of Business at Temple University\"\n ]\n },\n \"memberOf\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n }\n},\n\"image\": {\n\"@type\": \"ImageObject\",\n\"url\": \"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Equelle_Thumbnail.png?v=1685216816\",\n\"width\": \"3367\",\n\"height\": \"3367\"\n},\n\"citation\": [\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25692726\/\", \n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34038497\/\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22409590\/\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17106282\/\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21992596\/\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19131846\/\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21341397\/\",\n\"https:\/\/equelle.com\/\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35691259\/\",\n\"https:\/\/illuminatelabs.org\/products\/panax-ginseng-extract\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32762030\/\"\n],\n\"mentions\": [{\n \"@type\": \"Thing\",\n \"name\": \"S-equol\"\n },\n {\n \"@type\": \"Thing\",\n \"name\": \"calcium\"\n },\n {\n \"@type\": \"Thing\",\n \"name\": \"hot flashes\"\n },\n {\n \"@type\": \"Thing\",\n \"name\": \"depression\"\n },\n {\n \"@type\": \"Organization\",\n \"name\": \"Amazon\"\n },\n {\n \"@type\": \"Brand\",\n \"name\": \"Heather Hirsch\"\n }\n],\n\"datePublished\": \"2023-05-27\",\n\"copyrightHolder\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n},\n\"publisher\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\",\n \"url\": \"https:\/\/illuminatelabs.org\/\",\n \"description\": \"Illuminate Labs is the most transparent supplement company in the U.S., and is a leading publisher of research-based health information.\",\n \"knowsAbout\": \"supplements, science, nutrition, exercise, health, medication, pharmaceutical, wellness, diet, weight loss, medical research\",\n \"publishingPrinciples\": \"https:\/\/illuminatelabs.org\/pages\/editorial-guidelines\",\n \"memberOf\": [\n {\n \"@type\": \"Organization\",\n \"name\": \"U.S. Chamber of Commerce\",\n \"url\": \"https:\/\/www.uschamber.com\/\"\n },\n {\n \"@type\": \"Organization\",\n \"name\": \"Certified B Corp\",\n \"url\": \"https:\/\/www.bcorporation.net\/en-us\/\"\n },\n {\n \"@type\": \"Organization\",\n \"name\": \"Natural Products Association\",\n \"url\": \"https:\/\/www.npanational.org\/\"\n }\n ], \n \"logo\": {\n \"@type\": \"ImageObject\",\n \"url\": \"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Illuminate_Labs_Favicon_48x48_7595c3cc-e27b-47b8-a4fe-edcc7ed9b29a.png?v=1666502785\", \n \"width\": 48,\n \"height\": 48\n},\n \"foundingDate\": \"2019-01-30\",\n \"sameAs\": [\n \"https:\/\/www.instagram.com\/illuminatelabs\",\n \"https:\/\/twitter.com\/illuminatelabs\",\n \"https:\/\/www.linkedin.com\/company\/illuminate-labs-supplements\",\n \"https:\/\/www.youtube.com\/channel\/UCpgSJAsIPb-fZ25djtTxBEA\"\n ]\n }\n}\n\/\/ ]]\u003e\u003c\/script\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Equelle_Review_Article_Header_Image_Optimized.png?v=1685202139\" alt=\"\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan class=\"dc\"\u003eE\u003c\/span\u003equelle is a dietary supplement used for the treatment of menopause symptoms like hot flashes and sleep disruption. The brand claims that this is “the only supplement with S-equol” and that it “is proven” to naturally address the root cause of estrogen decline symptoms.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eBut is S-equol actually proven in research studies to treat menopause symptoms or is this just a marketing claim? Does Equelle contain any questionable ingredients from a health perspective? Is the supplement clinically proven to work? And how do real users rate and describe the effects of Equelle?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIn this article we’ll answer all of these questions and more as we analyze the ingredients in Equelle based on medical studies to give our take on whether the supplement is likely to be effective, or if it’s a waste of money.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe’ll also review the clinical trial on Equelle to see if the product is proven to reduce menopause symptoms, and feature real, unsponsored Equelle user reviews.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eIngredient Analysis\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Equelle_Ingredients_Optimized.png?v=1685202157\" alt=\"Equelle ingredients\" style=\"display: block; margin-left: auto; margin-right: auto;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe ingredients in Equelle are shown above.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eS-equol\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e is the core active ingredient that the brand highlights in their marketing.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThis ingredient has been studied in clinical trials.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eA \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25692726\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emedical review\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e on s-equol for menopause published in the \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eJournal of Women’s Health\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e reports that a trial on women in the US found significant reductions in menopause symptoms.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe study authors concluded the following:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e“...preliminary evidence warrants clinicians discussing the potential of S-equol for the alleviation of [menopause symptoms] with patients.”\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eA 2021 \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34038497\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eclinical trial\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e found that s-equol reduces inflammation and alleviates depressive symptoms in mice.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eA 2021 \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22409590\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eclinical trial\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e found that s-equol significantly reduced hot flashes in menopausal women, although the most effective dose was shown to be at or over 20 milligrams (mg), while the amount per-serving in Equelle is only 5 mg.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCalcium\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e is the second active ingredient in this formulation, which is \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17106282\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eclinically shown\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e to reduce bone loss in menopausal women. However, we can’t find any medical studies showing this mineral treats menopausal symptoms.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAll of the inactive ingredients in Equelle are considered safe and non-toxic, which is a good sign.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOverall we consider this supplement somewhat likely to relieve menopausal symptoms. One of its two active ingredients has significant research backing. But the dose of that ingredient appears lower than in the clinical trials we reviewed.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eBut did Equelle’s clinical trial prove the supplement to be effective? We’ll review in the next section.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eEquelle Clinical Trial Analysis\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Equelle_Clinical_Trial_Claims_Optimized.png?v=1685202185\" alt=\"Equelle clinical trial claims\" style=\"display: block; margin-left: auto; margin-right: auto;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eEquelle claims that their supplement is clinically proven to be effective, as shown in the image above from the brand’s website.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eTo the credit of the brand, they appear to have published research in legitimate, peer-reviewed medical journals on the efficacy of their supplement.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOne \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21992596\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003etrial\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e found that the supplement reduced hot flashes.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAnother \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19131846\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003etrial\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e published in the \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eMenopause\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e journal found that the supplement reduced all menopausal symptoms except for depression.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eHere’s our concern: neither of the trials specifically name Equelle, and both trials use a higher dose (10 mg) than the dose in Equelle (5 mg).\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eEquelle’s website refers to these trials as though they were on the Equelle supplement, not just the active ingredient in the supplement, so we're left unsure of the status of these trials.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe hope that in the future Equelle publishes clarifications regarding these issues. In the vast majority of clinical trials on supplements that we’ve reviewed on Illuminate Health, the supplement in question was named in the trial.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe find it unusual that the dose in the trial is different from the dose in the supplement.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eBut does Equelle cause side effects? We’ll answer in the next section.\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eDoes Equelle Cause Side Effects?\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eBoth of the clinical trials cited on Equelle’s website reported no serious side effects.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe first trial cited in the above section reported the following: “No changes in clinical parameters or serious adverse effects were reported.”\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe second trial also found that no adverse effects were reported.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eA 2011 \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21341397\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eclinical trial\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e on the core active ingredient in Equelle (s-equol) reported no adverse effects even at a dose much higher than that in Equelle.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eBased on the available research, we do not consider Equelle likely to cause side effects\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e, although any consumer can have an individual response to a supplement and should clear its use with their doctor first.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eReal Equelle User Reviews\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eHere’s a testimonial from an Equelle user named Patricia Smith:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ciframe width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/7gmRnRbJlH4\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen=\"\"\u003e\u003c\/iframe\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eBelow is an Equelle testimonial from a woman named Holly Matthews:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ciframe width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/9tIBe_8TgGA\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen=\"\"\u003e\u003c\/iframe\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eWhy We Recommend Avoiding Equelle on Amazon\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Equelle_Amazon_Optimized.png?v=1685202236\" alt=\"Equelle Amazon listing\" style=\"display: block; margin-left: auto; margin-right: auto;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThere is a product currently sold on Amazon branded “Equelle” but this doesn’t appear to be the official Equelle supplement.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAs shown below, the Equelle sold on Amazon has entirely different packaging: \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe ingredients are not listed for this product which is even more concerning.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe official Equelle only appears to be sold on the brand’s website, which consumers can access \u003c\/span\u003e\u003ca href=\"https:\/\/equelle.com\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eat this link\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eMedical Experts Discuss Equelle\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eA YouTube creator and MD named Heather Hirsch shared her opinion on Equelle in a video on menopause supplements for hot flashes. We’ve timestamped the below video to begin when she discusses Equelle:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ciframe width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/5mQZ4z3-7SM?start=110\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen=\"\"\u003e\u003c\/iframe\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eA TikTok creator and doctor named “drmaryclaire” shared her thoughts on Equelle in response to a user’s question:\u003c\/span\u003e\u003c\/p\u003e\n\u003cblockquote class=\"tiktok-embed\" cite=\"https:\/\/www.tiktok.com\/@drmaryclaire\/video\/7150768643133984042\" data-video-id=\"7150768643133984042\" style=\"max-width: 325px; min-width: 325px;\"\u003e\n\u003csection\u003e\u003ca target=\"_blank\" title=\"@drmaryclaire\" href=\"https:\/\/www.tiktok.com\/@drmaryclaire?refer=embed\" rel=\"noopener noreferrer\"\u003e@drmaryclaire\u003c\/a\u003e \u003ca title=\"answer\" target=\"_blank\" href=\"https:\/\/www.tiktok.com\/tag\/answer?refer=embed\" rel=\"noopener noreferrer\"\u003e#answer\u003c\/a\u003e to @sem0517 \u003ca title=\"estrogen\" target=\"_blank\" href=\"https:\/\/www.tiktok.com\/tag\/estrogen?refer=embed\" rel=\"noopener noreferrer\"\u003e#estrogen\u003c\/a\u003e \u003ca title=\"hormones\" target=\"_blank\" href=\"https:\/\/www.tiktok.com\/tag\/hormones?refer=embed\" rel=\"noopener noreferrer\"\u003e#hormones\u003c\/a\u003e \u003ca title=\"hrt\" target=\"_blank\" href=\"https:\/\/www.tiktok.com\/tag\/hrt?refer=embed\" rel=\"noopener noreferrer\"\u003e#hrt\u003c\/a\u003e \u003ca title=\"hrtiktok\" target=\"_blank\" href=\"https:\/\/www.tiktok.com\/tag\/hrtiktok?refer=embed\" rel=\"noopener noreferrer\"\u003e#hrtiktok\u003c\/a\u003e \u003ca title=\"tiktokdoc\" target=\"_blank\" href=\"https:\/\/www.tiktok.com\/tag\/tiktokdoc?refer=embed\" rel=\"noopener noreferrer\"\u003e#tiktokdoc\u003c\/a\u003e \u003ca title=\"womenshealth\" target=\"_blank\" href=\"https:\/\/www.tiktok.com\/tag\/womenshealth?refer=embed\" rel=\"noopener noreferrer\"\u003e#womenshealth\u003c\/a\u003e \u003ca title=\"obgyndoctor\" target=\"_blank\" href=\"https:\/\/www.tiktok.com\/tag\/obgyndoctor?refer=embed\" rel=\"noopener noreferrer\"\u003e#obgyndoctor\u003c\/a\u003e \u003ca title=\"pauselife\" target=\"_blank\" href=\"https:\/\/www.tiktok.com\/tag\/pauselife?refer=embed\" rel=\"noopener noreferrer\"\u003e#pauselife\u003c\/a\u003e \u003ca title=\"menopausesupport\" target=\"_blank\" href=\"https:\/\/www.tiktok.com\/tag\/menopausesupport?refer=embed\" rel=\"noopener noreferrer\"\u003e#menopausesupport\u003c\/a\u003e \u003ca title=\"pauselife\" target=\"_blank\" href=\"https:\/\/www.tiktok.com\/tag\/pauselife?refer=embed\" rel=\"noopener noreferrer\"\u003e#pauselife\u003c\/a\u003e \u003ca target=\"_blank\" title=\"♬ original sound - Dr. M.C. Haver\" href=\"https:\/\/www.tiktok.com\/music\/original-sound-7150768658879384362?refer=embed\" rel=\"noopener noreferrer\"\u003e♬ original sound - Dr. M.C. Haver\u003c\/a\u003e\u003c\/section\u003e\n\u003c\/blockquote\u003e\n\u003cscript async=\"\" src=\"https:\/\/www.tiktok.com\/embed.js\"\u003e\u003c\/script\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cstrong\u003eCan Ginseng Relieve Menopause Symptoms?\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Ginseng_Image.png?v=1672046103\" alt=\"\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003e\u003cem\u003ePanax ginseng\u003c\/em\u003e\u003c\/strong\u003e, which is a plant native to Asia, has been studied in various clinical trials for its effects on menopausal symptoms.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eA\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35691259\/\"\u003emedical review\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003epublished in the\u003cspan\u003e \u003c\/span\u003e\u003cem\u003eComplementary Therapies in Clinical Practice\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003ejournal analyzed data from 15 clinical trials on ginseng in menopausal women and concluded the following:\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003e\"ginseng can significantly reduce hot flashes, menopausal symptoms, and quality of life in menopausal women.\"\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIlluminate Labs sells a\u003cspan\u003e \u003ca href=\"https:\/\/illuminatelabs.org\/products\/panax-ginseng-extract\"\u003ePanax Ginseng Extract Supplement\u003c\/a\u003e\u003c\/span\u003e which is third-party tested to ensure label accuracy, potency and purity, and which contains no questionable additive ingredients. Interested consumers can check out Illuminate Labs Panax Ginseng Extract\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/illuminatelabs.org\/products\/panax-ginseng-extract\"\u003eat this link\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eto the product page on our website, where the supplement can be purchased for only\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003e$15\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eon a subscription basis.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMilk thistle\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eis another research-backed plant supplement for menopause. A 2020\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32762030\/\"\u003eclinical trial\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003efound that milk thistle supplementation decreased the severity and frequency of hot flashes by 70% in menopausal women.\u003c\/p\u003e\n\u003cp\u003e\u003ca rel=\"sponsored\" href=\"https:\/\/shareasale.com\/r.cfm?b=1592159\u0026amp;u=3153363\u0026amp;m=100043\u0026amp;urllink=www%2Efuturekind%2Ecom%2Fproducts%2Fvegan%2Dmilk%2Dthistle%2Dsupplement\u0026amp;afftrack=\"\u003eFuture Kind Milk Thistle Extract\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eis our top milk thistle supplement pick because it's effectively dosed and costs only $19.99. Interested consumers can check out Future Kind Milk Thistle Extract\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"sponsored\" href=\"https:\/\/shareasale.com\/r.cfm?b=1592159\u0026amp;u=3153363\u0026amp;m=100043\u0026amp;urllink=www%2Efuturekind%2Ecom%2Fproducts%2Fvegan%2Dmilk%2Dthistle%2Dsupplement\u0026amp;afftrack=\"\u003eat this link\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eto the product page on the official brand's website.\u003c\/p\u003e\n\u003cp\u003eBoth of the supplements recommended in this section are entirely free of questionable additive ingredients like titanium dioxide.\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003ePros and Cons of Equelle\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eHere are the pros and cons of Equelle in our opinion:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cb\u003ePros:\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eActive ingredient is clinically shown to work\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eActive ingredient has significant research-backing\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eDoesn’t appear to cause side effects\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eNo unhealthy additive ingredients\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cb\u003eCons:\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe clinical trials cited by Equelle use higher doses than in one serving of the supplement\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eConclusion\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eEquelle is one of the more impressive menopause supplements that we’ve reviewed on Illuminate Health.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIt appears to work, and its core active ingredient is shown to be effective at reducing menopause symptoms in multiple clinical trials.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe main question we have about Equelle is that the clinical trials cited by the brand don’t appear to mention the brand by name, just the active ingredient, which is confusing to us. The clinical trials also use a higher dose than is contained in one serving of Equelle.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe do not believe that Equelle is likely to cause side effects, because its active ingredient has not been shown to cause any significant side effects in the studies we reviewed, and the inactive ingredients in this supplement are safe and non-toxic.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIt’s challenging to find unsponsored customer reviews of this product since it’s not sold on Amazon, but in this article we shared some opinions of the supplement published by doctors.\u003c\/span\u003e\u003c\/p\u003e","blog_id":49281925193,"author":"Calloway Cook","user_id":26601750601,"published_at":"2023-05-27T15:44:40-04:00","updated_at":"2023-06-01T11:26:48-04:00","summary_html":"We analyze the ingredients in Equelle based on medical studies to give our take on whether the supplement is likely to be effective for relieving menopause symptoms or if it's a waste of money. We feature real customer reviews.","template_suffix":"","handle":"equelle-review","tags":"_related:menopause"}

Equelle Review: Most Effective Menopause Supplement?

Equelle Review: Most Effective Menopause Supplement?


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Equelle is a dietary supplement used for the treatment of menopause symptoms like hot flashes and sleep disruption. The brand claims that this is “the only supplement with S-equol” and that it “is proven” to naturally address the root cause of estrogen decline symptoms.

But is S-equol actually proven in research studies to treat menopause symptoms or is this just a marketing claim? Does Equelle contain any questionable ingredients from a health perspective? Is the supplement clinically proven to work? And how do real users rate and describe the effects of Equelle?

In this article we’ll answer all of these questions and more as we analyze the ingredients in Equelle based on medical studies to give our take on whether the supplement is likely to be effective, or if it’s a waste of money.

We’ll also review the clinical trial on Equelle to see if the product is proven to reduce menopause symptoms, and feature real, unsponsored Equelle user reviews.

Ingredient Analysis

Equelle ingredients

The ingredients in Equelle are shown above.

S-equol is the core active ingredient that the brand highlights in their marketing.

This ingredient has been studied in clinical trials.

A medical review on s-equol for menopause published in the Journal of Women’s Health reports that a trial on women in the US found significant reductions in menopause symptoms.

The study authors concluded the following:

“...preliminary evidence warrants clinicians discussing the potential of S-equol for the alleviation of [menopause symptoms] with patients.”

A 2021 clinical trial found that s-equol reduces inflammation and alleviates depressive symptoms in mice.

A 2021 clinical trial found that s-equol significantly reduced hot flashes in menopausal women, although the most effective dose was shown to be at or over 20 milligrams (mg), while the amount per-serving in Equelle is only 5 mg.

Calcium is the second active ingredient in this formulation, which is clinically shown to reduce bone loss in menopausal women. However, we can’t find any medical studies showing this mineral treats menopausal symptoms.

All of the inactive ingredients in Equelle are considered safe and non-toxic, which is a good sign.

Overall we consider this supplement somewhat likely to relieve menopausal symptoms. One of its two active ingredients has significant research backing. But the dose of that ingredient appears lower than in the clinical trials we reviewed.

But did Equelle’s clinical trial prove the supplement to be effective? We’ll review in the next section.

Equelle Clinical Trial Analysis

Equelle clinical trial claims

Equelle claims that their supplement is clinically proven to be effective, as shown in the image above from the brand’s website.

To the credit of the brand, they appear to have published research in legitimate, peer-reviewed medical journals on the efficacy of their supplement.

One trial found that the supplement reduced hot flashes.

Another trial published in the Menopause journal found that the supplement reduced all menopausal symptoms except for depression.

Here’s our concern: neither of the trials specifically name Equelle, and both trials use a higher dose (10 mg) than the dose in Equelle (5 mg).

Equelle’s website refers to these trials as though they were on the Equelle supplement, not just the active ingredient in the supplement, so we're left unsure of the status of these trials.

We hope that in the future Equelle publishes clarifications regarding these issues. In the vast majority of clinical trials on supplements that we’ve reviewed on Illuminate Health, the supplement in question was named in the trial.

We find it unusual that the dose in the trial is different from the dose in the supplement.

But does Equelle cause side effects? We’ll answer in the next section.

Does Equelle Cause Side Effects?

Both of the clinical trials cited on Equelle’s website reported no serious side effects.

The first trial cited in the above section reported the following: “No changes in clinical parameters or serious adverse effects were reported.”

The second trial also found that no adverse effects were reported.

A 2011 clinical trial on the core active ingredient in Equelle (s-equol) reported no adverse effects even at a dose much higher than that in Equelle.

Based on the available research, we do not consider Equelle likely to cause side effects, although any consumer can have an individual response to a supplement and should clear its use with their doctor first.

Real Equelle User Reviews

Here’s a testimonial from an Equelle user named Patricia Smith:

Below is an Equelle testimonial from a woman named Holly Matthews:

Why We Recommend Avoiding Equelle on Amazon

Equelle Amazon listing

There is a product currently sold on Amazon branded “Equelle” but this doesn’t appear to be the official Equelle supplement.

As shown below, the Equelle sold on Amazon has entirely different packaging: 

The ingredients are not listed for this product which is even more concerning.

The official Equelle only appears to be sold on the brand’s website, which consumers can access at this link.

Medical Experts Discuss Equelle

A YouTube creator and MD named Heather Hirsch shared her opinion on Equelle in a video on menopause supplements for hot flashes. We’ve timestamped the below video to begin when she discusses Equelle:

A TikTok creator and doctor named “drmaryclaire” shared her thoughts on Equelle in response to a user’s question:

@drmaryclaire #answer to @sem0517 #estrogen #hormones #hrt #hrtiktok #tiktokdoc #womenshealth #obgyndoctor #pauselife #menopausesupport #pauselife ♬ original sound - Dr. M.C. Haver

Can Ginseng Relieve Menopause Symptoms?

Panax ginseng, which is a plant native to Asia, has been studied in various clinical trials for its effects on menopausal symptoms.

A medical review published in the Complementary Therapies in Clinical Practice journal analyzed data from 15 clinical trials on ginseng in menopausal women and concluded the following: "ginseng can significantly reduce hot flashes, menopausal symptoms, and quality of life in menopausal women."

Illuminate Labs sells a Panax Ginseng Extract Supplement which is third-party tested to ensure label accuracy, potency and purity, and which contains no questionable additive ingredients. Interested consumers can check out Illuminate Labs Panax Ginseng Extract at this link to the product page on our website, where the supplement can be purchased for only $15 on a subscription basis.

Milk thistle is another research-backed plant supplement for menopause. A 2020 clinical trial found that milk thistle supplementation decreased the severity and frequency of hot flashes by 70% in menopausal women.

Future Kind Milk Thistle Extract is our top milk thistle supplement pick because it's effectively dosed and costs only $19.99. Interested consumers can check out Future Kind Milk Thistle Extract at this link to the product page on the official brand's website.

Both of the supplements recommended in this section are entirely free of questionable additive ingredients like titanium dioxide.

Pros and Cons of Equelle

Here are the pros and cons of Equelle in our opinion:

Pros:

  • Active ingredient is clinically shown to work
  • Active ingredient has significant research-backing
  • Doesn’t appear to cause side effects
  • No unhealthy additive ingredients

Cons:

  • The clinical trials cited by Equelle use higher doses than in one serving of the supplement
Stay up-to-date on our research reviews

Conclusion

Equelle is one of the more impressive menopause supplements that we’ve reviewed on Illuminate Health.

It appears to work, and its core active ingredient is shown to be effective at reducing menopause symptoms in multiple clinical trials.

The main question we have about Equelle is that the clinical trials cited by the brand don’t appear to mention the brand by name, just the active ingredient, which is confusing to us. The clinical trials also use a higher dose than is contained in one serving of Equelle.

We do not believe that Equelle is likely to cause side effects, because its active ingredient has not been shown to cause any significant side effects in the studies we reviewed, and the inactive ingredients in this supplement are safe and non-toxic.

It’s challenging to find unsponsored customer reviews of this product since it’s not sold on Amazon, but in this article we shared some opinions of the supplement published by doctors.