{"id":606097506610,"title":"OneSkin Review: A Magic Peptide for Skin?","created_at":"2023-08-20T22:22:14-04:00","body_html":"\u003cscript type=\"application\/ld+json\"\u003e\/\/ \u003c![CDATA[\n{\n \"@context\": \"https:\/\/schema.org\",\n \"@type\": \"Article\",\n \"headline\": \"OneSkin Review: A Magic Peptide for Skin?\",\n \"keywords\": \"oneskin, oneskin review, oneskin reviews, one skin review, one skin reviews\",\n \"description\": \"Our research team analyzes medical studies on the peptide in OneSkin and the other active ingredients used by the brand, to give our take on whether OneSkin is likely to be effective for anti-aging or if it's a waste of money. We feature a real customer's before-and-after images.\",\n \"url\": \"https:\/\/illuminatelabs.org\/blogs\/health\/oneskin-review\",\n\"author\": {\n \"@type\": \"Person\",\n \"name\": \"Calloway Cook\",\n \"url\": \"https:\/\/illuminatelabs.org\/pages\/calloway-cook\",\n \"sameAs\": \"https:\/\/www.linkedin.com\/in\/calloway-cook\/\",\n \"jobTitle\": \"President\",\n \"knowsAbout\": \"entrepreneurship, dietary supplements, herbal supplements, eCommerce, medical research\",\n \"alumniOf\": {\n \"@type\": \"EducationalOrganization\",\n \"name\": \"S.I. Newhouse School of Public Communications at Syracuse University\"\n },\n \"memberOf\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n }\n},\n\"editor\": {\n \"@type\": \"Person\",\n \"name\": \"Beth Lertzman\",\n \"honorificSuffix\": \"M.D.\",\n \"url\": \"https:\/\/illuminatelabs.org\/pages\/beth-lertzman\",\n \"sameAs\": [\n \"https:\/\/www.linkedin.com\/in\/beth-lertzman-md-856619118\/\",\n \"https:\/\/health.usnews.com\/doctors\/beth-lertzman-517042\"\n ],\n \"jobTitle\": \"Dermatology Reviewer\",\n \"knowsAbout\": \"skincare, collagen, cosmetics, surgery, wrinkles, ingredients, formulation, clinical trials, clinical research\",\n \"alumniOf\": {\n \"@type\": \"EducationalOrganization\",\n \"name\": [\n \"University of Delaware\",\n \"Drexel University College of Medicine\",\n \"University of Rochester\"\n ]\n },\n \"memberOf\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n }\n },\n\"image\": {\n\"@type\": \"ImageObject\",\n\"url\": \"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/One_Skin_Thumbnail.png?v=1692584743\",\n\"width\": \"4000\",\n\"height\": \"4000\"\n},\n\"citation\": [\n\"https:\/\/www.nature.com\/articles\/s41514-023-00109-1\",\n\"https:\/\/clinicalepigeneticsjournal.biomedcentral.com\/articles\/10.1186\/s13148-020-00899-1\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18498456\/\",\n\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6489629\/\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30305560\/\",\n\"https:\/\/illuminatelabs.org\/blogs\/health\/agency-skincare-review\",\n\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5632318\/\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32387382\/\",\n\"https:\/\/www.oneskin.co\/products\/01-face-topical-supplement\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30287361\/\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24471735\/\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30681787\/\"\n],\n\"mentions\": [{\n \"@type\": \"Brand\",\n \"name\": \"OS-01\"\n },\n {\n \"@type\": \"Thing\",\n \"name\": \"peptide\"\n },\n {\n \"@type\": \"Thing\",\n \"name\": \"bentonite\"\n },\n {\n \"@type\": \"Thing\",\n \"name\": \"phenoxyethanol\"\n },\n {\n \"@type\": \"Brand\",\n \"name\": \"Aging Naturally With Jodylynn\"\n },\n {\n \"@type\": \"Brand\",\n \"name\": \"Hannah Louise Poston\"\n },\n {\n \"@type\": \"Organization\",\n \"name\": \"Amazon\"\n },\n {\n \"@type\": \"Brand\",\n \"name\": \"Facebook\"\n }\n],\n\"datePublished\": \"2023-08-20\",\n\"copyrightHolder\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n},\n\"publisher\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\",\n \"url\": \"https:\/\/illuminatelabs.org\/\",\n \"description\": \"Illuminate Labs is the most transparent supplement company in the U.S., and is a leading publisher of research-based health information.\",\n \"knowsAbout\": \"supplements, science, nutrition, exercise, health, medication, pharmaceutical, wellness, diet, weight loss, medical research\",\n \"publishingPrinciples\": \"https:\/\/illuminatelabs.org\/pages\/editorial-guidelines\",\n \"memberOf\": [\n {\n \"@type\": \"Organization\",\n \"name\": \"U.S. Chamber of Commerce\",\n \"url\": \"https:\/\/www.uschamber.com\/\"\n },\n {\n \"@type\": \"Organization\",\n \"name\": \"Certified B Corp\",\n \"url\": \"https:\/\/www.bcorporation.net\/en-us\/\"\n },\n {\n \"@type\": \"Organization\",\n \"name\": \"Natural Products Association\",\n \"url\": \"https:\/\/www.npanational.org\/\"\n }\n ],\n \"logo\": {\n \"@type\": \"ImageObject\",\n \"url\": \"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Illuminate_Labs_Favicon_48x48_7595c3cc-e27b-47b8-a4fe-edcc7ed9b29a.png?v=1666502785\", \n \"width\": 48,\n \"height\": 48\n},\n \"foundingDate\": \"2019-01-30\",\n \"sameAs\": [\n \"https:\/\/www.instagram.com\/illuminatelabs\",\n \"https:\/\/twitter.com\/illuminatelabs\",\n \"https:\/\/www.linkedin.com\/company\/illuminate-labs-supplements\",\n \"https:\/\/www.youtube.com\/channel\/UCpgSJAsIPb-fZ25djtTxBEA\"\n ]\n }\n}\n\/\/ ]]\u003e\u003c\/script\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cimg alt=\"\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/One_Skin_Review_Article_Header_Image_Optimized.png?v=1692584399\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan class=\"dc\"\u003eO\u003c\/span\u003eneSkin is an anti-aging cosmetic brand. The company claims to sell “the first skin longevity treatment scientifically proven to target the root cause of skin aging.”\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eBut is OneSkin actually proven to work in research studies, or is it a waste of money? Does the brand use research-backed ingredients? What about questionable additive ingredients? And how do real users rate and describe the effects of OneSkin?\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIn this article we’ll answer all of these questions and more, as we review medical studies on OneSkin to give our take on whether the brand is likely to be effective or not.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe’ll analyze the ingredients in one of OneSkin’s top products, and feature unsponsored customer reviews of the brand.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eIs OneSkin Proven to Work?\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOneSkin claims on their website that the peptide used in their formulations, called “OS-01,” is proven to reverse the skin’s biological age.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe company cites a 2023 \u003c\/span\u003e\u003ca href=\"https:\/\/www.nature.com\/articles\/s41514-023-00109-1\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eclinical trial\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e which found that \u003c\/span\u003e\u003cb\u003ethis peptide “promoted a healthy skin phenotype with structural and molecular resemblance to young ex vivo skin.”\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIt’s important to note that this was an \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ein vitro\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e (test tube) study, which is a weaker standard of evidence than an \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ein vivo\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e (live human patient) study.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eNevertheless, this early-stage research is highly impressive and \u003c\/span\u003e\u003cb\u003ethe study authors concluded that this peptide can reduce the biological age of human skin.\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe only other \u003c\/span\u003e\u003ca href=\"https:\/\/clinicalepigeneticsjournal.biomedcentral.com\/articles\/10.1186\/s13148-020-00899-1\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eresearch citation\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e on the OneSkin “Science” page is a \u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003emedical review\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003e published in the \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eClinical Therapeutics\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e journal that outlines a novel research process for identifying potentially effective anti-aging compounds.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOverall, we consider OneSkin’s peptide somewhat likely to work, given that it was shown in a test tube study to have an anti-aging effect.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eHowever, this peptide does not appear to have been proven to work yet in live human subjects.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eBut what other ingredients are in OneSkin and are they effective? We’ll analyze all of the ingredients in the next section.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eIngredient Analysis\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cimg alt=\"OneSkin OS-01 Face ingredients\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/OS_01_Face_Ingredients_Optimized.png?v=1692584419\" style=\"display: block; margin-left: auto; margin-right: auto;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe ingredients in “OS-01 Face,” which is the anti-aging facial cream sold by OneSkin, are shown above.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThere are a number of research-backed ingredients in this formulation beyond the OS-01 peptide.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eGlycerin\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e is \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18498456\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eclinically shown\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e to increase skin moisture content, suggesting it has a hydrating effect.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eSorbitan olivate\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e and \u003c\/span\u003e\u003cb\u003ecetearyl olivate\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e may have synergistic effects to naturally hydrate the skin, according to a \u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6489629\/\"\u003eclinical trial\u003c\/a\u003e \u003c\/span\u003e\u003cspan font-weight:=\"\"\u003epublished in the \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eClinical, Cosmetic and Investigational Dermatology\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e journal.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e\u003ci\u003eCarapa guianensis\u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e seed oil\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e was shown to promote collagen synthesis in a 2018 \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30305560\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eclinical trial\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eNiacinamide\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e is a type of B-vitamin that’s been shown in research studies to reduce the appearance of wrinkles, as we documented in our \u003c\/span\u003e\u003ca href=\"https:\/\/illuminatelabs.org\/blogs\/health\/agency-skincare-review\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eAgency Skincare reviews\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e article.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eBentonite\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e is a mineral-rich clay that was shown to have a healing effect on skin in a 2017 \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5632318\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emedical review\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThere are other active ingredients in this formulation with research backing, but for the sake of brevity we’ll simply state that it’s clear this cream has a large number of effective ingredients.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003ePhenoxyethanol\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e is the only inactive ingredient in OS-01 that may be questionable from a health perspective, as this synthetic preservative was found in a 2020 \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003ein vitro\u003c\/span\u003e\u003c\/i\u003e \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32387382\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eclinical trial\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e to be toxic to human skin cells.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOverall, we consider OneSkin’s facial cream likely to be effective not only for anti-aging but also for skin hydration and skin barrier repair given its numerous effective active ingredients.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe don’t currently recommend this product due to the inclusion of phenoxyethanol, but we do consider it to be of above-average quality.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eBut how do real users rate and describe the effects of OneSkin products? We’ll feature unsponsored customer reviews in the next section of this article.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eReal People Try OneSkin\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eA YouTube creator named “Aging Naturally With Jodylynn” shared her experience using OneSkin in an unsponsored video that includes before-and-after images:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ciframe width=\"560\" height=\"315\" src=\"https:\/\/www.youtube.com\/embed\/CEkH83Cpocw\" title=\"YouTube video player\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen=\"\"\u003e\u003c\/iframe\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eA YouTube creator named Hannah Louise Poston reviewed all of her skincare products including OneSkin. We’ve timestamped the below video to start at the point she begins discussing her experience using OneSkin:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ciframe title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/Zz6LuCF0cy4?start=397\" height=\"315\" width=\"560\" allowfullscreen=\"\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" frameborder=\"0\"\u003e\u003c\/iframe\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eWhere to Buy OneSkin for the Best Price\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOneSkin appears to only be sold on the brand’s website and Amazon. Here are the current prices for OS-01:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eOne-Time Purchase\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eBrand website: $120 (free shipping, \u003c\/span\u003e\u003ca href=\"https:\/\/www.oneskin.co\/products\/01-face-topical-supplement\"\u003e\u003cspan style=\"font-weight: 400;\"\u003elink\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAmazon: $120 (free shipping, \u003c\/span\u003e\u003ca href=\"https:\/\/amzn.to\/3YFK88X\" rel=\"sponsored\"\u003e\u003cspan style=\"font-weight: 400;\"\u003elink\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSubscription\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAmazon: $120 (free shipping, \u003c\/span\u003e\u003ca href=\"https:\/\/amzn.to\/3YFK88X\" rel=\"sponsored\"\u003e\u003cspan style=\"font-weight: 400;\"\u003elink\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eBrand website: $99 (free shipping, \u003c\/span\u003e\u003ca href=\"https:\/\/www.oneskin.co\/products\/01-face-topical-supplement\"\u003e\u003cspan style=\"font-weight: 400;\"\u003elink\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e)\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eReal Customers Review OneSkin\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAmazon is a better resource for honest customer reviews than a brand’s website in our opinion.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOneSkin OS-01 has been reviewed 38 times on Amazon at the time of publishing this article, with an average review rating of 4 out of 5 stars.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe top positive review from a verified purchaser is written by a user named “AKPaula” who gives the cream a 5\/5 star rating and appreciates the effects and convenience:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e“It's only been about a week, but I'm very happy with the results of the OneSkin OS-01 essential moisturizer and the OS-01 eye cream.\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e An added bonus is that after purchasing the starter bottle, I can purchase a refill to insert into the container.”\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe top negative review from a verified purchaser comes from a user named “Just me and my zoo” who gives the cream a 1\/5 star rating and claimed to experience both side effects and negative aesthetic effects:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e“After using the supplement twice a day for 5 days, \u003c\/span\u003e\u003cb\u003emy skin started getting getting itchy, and I had a dry patch on my jawline\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e so I added my night cream. My skin still felt awful so next I decided to add my serum back into my routine. \u003c\/span\u003e\u003cb\u003eI also started to notice that the fine lines around my eyes were starting to look more pronounced\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e so I added my eye cream back into my routine.”\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOneSkin has an average review rating of 3.3 out of 5 stars on Facebook.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eOur Clean Skincare Picks\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Skincare_Products_Image_Optimized.png?v=1664754145\" alt=\"\"\u003e\u003c\/p\u003e\n\u003cp\u003eThere are skincare products that contain ingredients shown in clinical trials to be effective for reducing wrinkles and improving skin quality generally.\u003c\/p\u003e\n\u003cp\u003e\u003ca rel=\"sponsored\" href=\"http:\/\/track.revoffers.com\/aff_c?offer_id=155\u0026amp;aff_id=7240\u0026amp;url_id=2077\"\u003e\u003cspan\u003eAnnie Mak Vitamin C Serum\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e is our top skin cream pick because of its effective and clean formulation. It contains \u003c\/span\u003e\u003cb\u003ehyaluronic acid\u003c\/b\u003e\u003cspan\u003e which was described as a \u003c\/span\u003e\u003cb\u003e\"skin-rejuvenating biomedicine\"\u003c\/b\u003e\u003cspan\u003e in a \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30287361\/\"\u003e\u003cspan\u003emedical review\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e due to its ability to reduce wrinkles and signs of facial aging.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eInterested consumers can check out Annie Mak Vitamin C Serum \u003ca rel=\"sponsored\" href=\"http:\/\/track.revoffers.com\/aff_c?offer_id=155\u0026amp;aff_id=7240\u0026amp;url_id=2077\"\u003eat this link\u003c\/a\u003e to the product page on the official brand's website.\u003c\/p\u003e\n\u003cp\u003e\u003ca rel=\"sponsored\" href=\"http:\/\/track.revoffers.com\/aff_c?offer_id=159\u0026amp;aff_id=7240\u0026amp;url_id=2174\"\u003eHydraglow\u003c\/a\u003e\u003cspan\u003e \u003c\/span\u003eis our top moisturizer pick. It features\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003ebakuchiol\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eas an active ingredient which was described in a 2014 \u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24471735\/\"\u003eclinical trial\u003c\/a\u003e as\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003e\"clinically proven to have anti-aging effects.\"\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eInterested consumers can check out HydraGlow\u003cspan\u003e \u003c\/span\u003e\u003ca rel=\"sponsored\" href=\"http:\/\/track.revoffers.com\/aff_c?offer_id=159\u0026amp;aff_id=7240\u0026amp;url_id=2174\"\u003eat this link\u003c\/a\u003e to the product page on the official brand's website.\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe only oral supplement we recommend for skin quality improvement is \u003c\/span\u003e\u003ca rel=\"sponsored\" href=\"https:\/\/bulletproof.fdf2.net\/c\/3271428\/1278011\/9221\"\u003e\u003cspan\u003eBulletproof Collagen Powder\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eOral \u003c\/span\u003e\u003cb\u003ecollagen\u003c\/b\u003e\u003cspan\u003e supplementation was shown in a \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30681787\/\"\u003e\u003cspan\u003emedical review\u003c\/span\u003e\u003c\/a\u003e\u003cspan\u003e published in the \u003c\/span\u003e\u003ci\u003e\u003cspan\u003eJournal of Drugs in Dermatology\u003c\/span\u003e\u003c\/i\u003e\u003cspan\u003e \u003c\/span\u003e\u003cb\u003eto improve visible signs of skin aging as well as improve skin elasticity and skin hydration\u003c\/b\u003e\u003cspan\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eInterested consumers can check out Bulletproof Collagen Powder \u003ca rel=\"sponsored\" href=\"https:\/\/bulletproof.fdf2.net\/c\/3271428\/1278011\/9221\"\u003eat this link\u003c\/a\u003e to the product page on the brand's official website.\u003c\/p\u003e\n\u003cp\u003eNone of the products recommended in this section contain additive ingredients that we consider questionable from a health perspective.\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003ePros and Cons of OneSkin\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eHere are the pros and cons of OneSkin in our opinion:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cb\u003ePros:\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eNovel technology\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eMay actually reverse aging in skin\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eMany research-backed active ingredients\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cb\u003eCons:\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eExpensive\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eDoesn’t appear clinically tested in humans\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eContains phenoxyethanol\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eMediocre online customer reviews\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eConclusion\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOneSkin appears to be developing legitimate proprietary anti-aging technology, which is a refreshing change from most cosmetic brands we review on Illuminate Health that use similar active ingredients and just brand them differently.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThis company has developed a peptide that reverses aging in skin in test tube studies.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe haven’t found any clinical trials in humans proving these results, but we’re hopeful that the company will fund such studies in the future.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe don’t currently recommend this brand due to the lack of studies with human participants, as well as the inclusion of synthetic preservatives.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOnline customer reviews of the brand are unimpressive, but involve a small number of total users.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eFor consumers interested in trying OneSkin, the brand’s website has the best price on subscription orders.\u003c\/span\u003e\u003c\/p\u003e","blog_id":49281925193,"author":"Calloway Cook","user_id":26601750601,"published_at":"2023-08-20T22:30:30-04:00","updated_at":"2024-01-11T13:01:26-05:00","summary_html":"We analyze medical studies on the peptide in OneSkin and the other active ingredients used by the brand, to give our take on whether OneSkin is likely to be effective for anti-aging or if it's a waste of money. We feature a real customer's before-and-after images.","template_suffix":"","handle":"oneskin-review","tags":"_related:anti-aging"}

OneSkin Review: A Magic Peptide for Skin?

OneSkin Review: A Magic Peptide for Skin?


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Read our Editorial Guidelines to learn more about what makes our site the premier resource for online health information.

OneSkin is an anti-aging cosmetic brand. The company claims to sell “the first skin longevity treatment scientifically proven to target the root cause of skin aging.”

But is OneSkin actually proven to work in research studies, or is it a waste of money? Does the brand use research-backed ingredients? What about questionable additive ingredients? And how do real users rate and describe the effects of OneSkin?

In this article we’ll answer all of these questions and more, as we review medical studies on OneSkin to give our take on whether the brand is likely to be effective or not.

We’ll analyze the ingredients in one of OneSkin’s top products, and feature unsponsored customer reviews of the brand.

Is OneSkin Proven to Work?

OneSkin claims on their website that the peptide used in their formulations, called “OS-01,” is proven to reverse the skin’s biological age.

The company cites a 2023 clinical trial which found that this peptide “promoted a healthy skin phenotype with structural and molecular resemblance to young ex vivo skin.”

It’s important to note that this was an in vitro (test tube) study, which is a weaker standard of evidence than an in vivo (live human patient) study.

Nevertheless, this early-stage research is highly impressive and the study authors concluded that this peptide can reduce the biological age of human skin.

The only other research citation on the OneSkin “Science” page is a medical review published in the Clinical Therapeutics journal that outlines a novel research process for identifying potentially effective anti-aging compounds.

Overall, we consider OneSkin’s peptide somewhat likely to work, given that it was shown in a test tube study to have an anti-aging effect.

However, this peptide does not appear to have been proven to work yet in live human subjects.

But what other ingredients are in OneSkin and are they effective? We’ll analyze all of the ingredients in the next section.

Ingredient Analysis

OneSkin OS-01 Face ingredients

The ingredients in “OS-01 Face,” which is the anti-aging facial cream sold by OneSkin, are shown above.

There are a number of research-backed ingredients in this formulation beyond the OS-01 peptide.

Glycerin is clinically shown to increase skin moisture content, suggesting it has a hydrating effect.

Sorbitan olivate and cetearyl olivate may have synergistic effects to naturally hydrate the skin, according to a clinical trial published in the Clinical, Cosmetic and Investigational Dermatology journal.

Carapa guianensis seed oil was shown to promote collagen synthesis in a 2018 clinical trial.

Niacinamide is a type of B-vitamin that’s been shown in research studies to reduce the appearance of wrinkles, as we documented in our Agency Skincare reviews article.

Bentonite is a mineral-rich clay that was shown to have a healing effect on skin in a 2017 medical review.

There are other active ingredients in this formulation with research backing, but for the sake of brevity we’ll simply state that it’s clear this cream has a large number of effective ingredients.

Phenoxyethanol is the only inactive ingredient in OS-01 that may be questionable from a health perspective, as this synthetic preservative was found in a 2020 in vitro clinical trial to be toxic to human skin cells.

Overall, we consider OneSkin’s facial cream likely to be effective not only for anti-aging but also for skin hydration and skin barrier repair given its numerous effective active ingredients.

We don’t currently recommend this product due to the inclusion of phenoxyethanol, but we do consider it to be of above-average quality.

But how do real users rate and describe the effects of OneSkin products? We’ll feature unsponsored customer reviews in the next section of this article.

Real People Try OneSkin

A YouTube creator named “Aging Naturally With Jodylynn” shared her experience using OneSkin in an unsponsored video that includes before-and-after images:

A YouTube creator named Hannah Louise Poston reviewed all of her skincare products including OneSkin. We’ve timestamped the below video to start at the point she begins discussing her experience using OneSkin:

Where to Buy OneSkin for the Best Price

OneSkin appears to only be sold on the brand’s website and Amazon. Here are the current prices for OS-01:

One-Time Purchase

Brand website: $120 (free shipping, link)

Amazon: $120 (free shipping, link)

Subscription

Amazon: $120 (free shipping, link)

Brand website: $99 (free shipping, link)

Real Customers Review OneSkin

Amazon is a better resource for honest customer reviews than a brand’s website in our opinion.

OneSkin OS-01 has been reviewed 38 times on Amazon at the time of publishing this article, with an average review rating of 4 out of 5 stars.

The top positive review from a verified purchaser is written by a user named “AKPaula” who gives the cream a 5/5 star rating and appreciates the effects and convenience:

“It's only been about a week, but I'm very happy with the results of the OneSkin OS-01 essential moisturizer and the OS-01 eye cream. An added bonus is that after purchasing the starter bottle, I can purchase a refill to insert into the container.”

The top negative review from a verified purchaser comes from a user named “Just me and my zoo” who gives the cream a 1/5 star rating and claimed to experience both side effects and negative aesthetic effects:

“After using the supplement twice a day for 5 days, my skin started getting getting itchy, and I had a dry patch on my jawline so I added my night cream. My skin still felt awful so next I decided to add my serum back into my routine. I also started to notice that the fine lines around my eyes were starting to look more pronounced so I added my eye cream back into my routine.”

OneSkin has an average review rating of 3.3 out of 5 stars on Facebook.

Our Clean Skincare Picks

There are skincare products that contain ingredients shown in clinical trials to be effective for reducing wrinkles and improving skin quality generally.

Annie Mak Vitamin C Serum is our top skin cream pick because of its effective and clean formulation. It contains hyaluronic acid which was described as a "skin-rejuvenating biomedicine" in a medical review due to its ability to reduce wrinkles and signs of facial aging.

Interested consumers can check out Annie Mak Vitamin C Serum at this link to the product page on the official brand's website.

Hydraglow is our top moisturizer pick. It features bakuchiol as an active ingredient which was described in a 2014 clinical trial as "clinically proven to have anti-aging effects."

Interested consumers can check out HydraGlow at this link to the product page on the official brand's website.

The only oral supplement we recommend for skin quality improvement is Bulletproof Collagen Powder.

Oral collagen supplementation was shown in a medical review published in the Journal of Drugs in Dermatology to improve visible signs of skin aging as well as improve skin elasticity and skin hydration.

Interested consumers can check out Bulletproof Collagen Powder at this link to the product page on the brand's official website.

None of the products recommended in this section contain additive ingredients that we consider questionable from a health perspective.

Pros and Cons of OneSkin

Here are the pros and cons of OneSkin in our opinion:

Pros:

  • Novel technology
  • May actually reverse aging in skin
  • Many research-backed active ingredients

Cons:

  • Expensive
  • Doesn’t appear clinically tested in humans
  • Contains phenoxyethanol
  • Mediocre online customer reviews
Stay up-to-date on our research reviews

Conclusion

OneSkin appears to be developing legitimate proprietary anti-aging technology, which is a refreshing change from most cosmetic brands we review on Illuminate Health that use similar active ingredients and just brand them differently.

This company has developed a peptide that reverses aging in skin in test tube studies.

We haven’t found any clinical trials in humans proving these results, but we’re hopeful that the company will fund such studies in the future.

We don’t currently recommend this brand due to the lack of studies with human participants, as well as the inclusion of synthetic preservatives.

Online customer reviews of the brand are unimpressive, but involve a small number of total users.

For consumers interested in trying OneSkin, the brand’s website has the best price on subscription orders.