ZuPOO Review: Why "Colon Cleansing" Doesn't Work

ZuPOO Review: Why "Colon Cleansing" Doesn't Work

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ZuPOO is a colon cleansing and gut support supplement sold by a brand called Umzu. The brand claims that this supplement can help "cleanse" the body, improve digestion and support weight loss.

But does ZuPOO contain ingredients proven in medical research to have these effects, or are these just marketing claims? Does ZuPOO contain any harmful ingredients? And how do real users rate and describe the effects of ZuPOO?

In this article we’ll answer all of these questions and more as we review every ingredient in ZuPOO based on medical research to give our take on whether the supplement is likely to be effective for improving gut health.

We'll document our concerns with some of the strange health claims made by ZuPOO's manufacturer, explain why colon cleansing is an illogical way to improve gut health, and share real, unsponsored ZuPOO user reviews.

Ingredient Analysis - Will ZuPOO Work?

ZuPOO ingredients

ZuPOO is formulated with a proprietary (prop) blend totalling 1,270 milligrams (mg).

A prop blend lists the total ingredient dose of the entire blend but does not list the individual dose of each ingredient, which we think is unfair to consumers. Without the individual ingredient doses it's difficult to determine if ingredients are effectively and safely dosed.

Cascara sagrada bark extract is the first-listed active ingredient, and is a laxative.

A medical review published in the LiverTox journal found that cascara can cause liver injury when used at high doses, which is why it's so unsafe for ZuPOO's manufacturer to not list the dose of this ingredient. The linked review states the following: "The time to onset of liver injury [from cascara use] has varied from a few days to 2 months of use."

Senna leaf powder is also a laxative. As we documented in our review of K3 Spark Mineral (another supplement including this ingredient), clinical studies show that senna can cause liver injury.

Milk thistle, which is typically used for liver health, has been shown in a medical review to cause diarrhea as a side effect. We do not understand why this ingredient would be included in a gut health supplement.

Burdock root powder was found in an animal study published in the Microorganisms journal to promote intestinal health, but the dose used (2.5% of overall diet) was far higher than the dose in ZuPOO.

We are unable to identify any ingredients in this formulation that we consider effectively dosed and likely to improve gut health based on a review of medical research. Overall we do not consider this supplement likely to be effective, and consider it potentially harmful due to the inclusion of two active ingredients associated with increased risk of liver injury.

This is one of the worst-formulated dietary supplements we have ever reviewed on Illuminate Health, and we recommend that consumers avoid both this supplement and all supplements sold by its parent brand Umzu.

Strange and Unscientific Health Claims on ZuPoo Website

ZuPOO questionable health claim 1

Umzu claims in a blog post about ZuPoo that "toxic waste" builds up in the body and the body becomes a "walking vessel of fecal toxicity." These claims are uncited, illogical and unscientific.

Fecal toxicity is an incredibly rare complication of severe colon disease or infection, and it's certainly not treated with dietary supplements.

The listed author of Umzu's blog post cited above is named Jayton Miller and does not appear to have any medical or scientific credentials according to Umzu's website.

This blog post previously had the absurd title: “Scientists Confirm: The Average Person is Carrying Around 5-20 Pounds of Poop in Their Body At Any Time.” Umzu has changed the title since our review was initially published.

ZuPOO questionable health claim 2

The claim is also made in the same promotional article that if you are not producing well-formed stools after each meal then there is "toxic build-up" inside your digestive system. This is false and again zero proof is provided for this claim.

An extensive 2010 medical review proved that normal bowel frequency is between three times weekly and three times daily. There's nothing wrong with passing stool after each meal, but passing stool at longer intervals does not necessarily indicate a health problem.

ZuPOO questionable health claim 3

Umzu's article describes “all that poop, just sitting there, rotting away inside their intestines and colon,” which is another claim that evidences a lack of basic understanding of human biology. Stool doesn’t “just sit” in the intestines and it certainly doesn’t “rot” -- it passes through the digestive tract before being expelled.

We find this type of fearmongering marketing to be unfair to consumers, and we urge both the FDA and FTC to investigate these health claims being made by Umzu. We strongly recommend that consumers entirely disregard health claims made by supplement companies that provide no proof of those claims.

Umzu Spam Email Issue

Umzu marketing spam

We visited the ZuPOO product page on Umzu's website while researching this article. We never consented to any marketing emails or input our email anywhere on their website.

Since visiting the Umzu site, we have received three spam emails from Umzu within 24 hours. We don't believe that companies should be allowed to send spam to people who don't even share their email address with the company.

We recommend avoiding the Umzu website so that you don't receive unsolicited marketing spam emails from a business that somehow accessed your personal email address without your consent.

Real, Unsponsored ZuPOO User Review

A TikTok creator named Nedi reviewed ZuPOO after 15 days of use, sharing how the supplement made them feel and the weight changes it caused:

@nedibailon This might be TMI. Day 1-15 #review @UMZU #zupoo #umzu #gutsupport #cleansegut #gutcleansing ♬ original sound - Nedi | Content Creator

Does Colon Cleansing Even Make Sense?

As stated in the intro section of this article, one of ZuPOO's claimed benefits is that it's a "colon cleanse" supplement. Many health brands claim that colon cleansing improves gut health but this is not backed by scientific research.

There are two types of colon cleanses: one from an injectable device inserted into the rectum that flushes out the colon with liquid (this is typically administered in medical settings like before a colonoscopy) and the other is via an oral supplement like ZuPOO.

A medical review published in the American Journal of Gastroenterology analyzed clinical trial data on colon cleanses for detoxification and general health promotion, and concluded that there was no benefit to colon cleanses for general health, and that the practice could cause side effects such as electrolyte imbalances.

A more recent clinical trial found that colon cleansing (which was recommended prior to a colonoscopy) had negative effects on the gut microbiome. The practice significantly reduced the levels of healthy bacteria in the gut.

A YouTube video published by a doctor named Jen Caudle explains why colon cleanses may not provide any benefits outside of specific medical circumstances:

ZuPOO Real Customer Reviews

ZuPOO is sold on Amazon which is a more objective resource for customer reviews than a brand's website in our opinion. The supplement has been reviewed over 10,000 times and has an average rating of 3.8 out of 5 stars.

The product scores a "B" grade on Fakespot, which is a software tool that detects potentially fraudulent Amazon reviews. This is a good sign that the reviews are legitimate.

The top positive review from a verified purchaser comes from a user named "Lyndse McPheeters" who claims that ZuPOO improved their gastrointestinal symptoms:

"This product was amazing! It works just like it says it does! You take it at night and the next day you have easy bowl movements. It’s not harsh so you’re not about to poop your self all day. I was having some really bad bloating and constipation, but after taking this I feel cleared out and much “lighter.” My tummy doesn’t feel tight and it’s easier for me to go on a more regular basis."

The top negative review from a verified purchaser is written by a user named "Chef Steven Hodge" who claims the supplement had no effects:

"I understand that everyone's body and digestive systems are quite different. However, the product did not work on me at all, ZERO EFFECT! Even Worse, The Bottle Was Short A Pill!"

Our Recommended Gut Health Supplement

The gut health supplement we recommend is Supergut Fiber Mix. This supplement provides 8 grams (g) of  fiber per serving and contains no questionable additive ingredients. The only ingredients are a blend of fiber powders including green banana powder resistant starch and resistant potato starch.

medical review published in the Advances in Nutrition journal analyzed data from various clinical trials and concluded that resistant starch intake was associated with improved gut health, weight loss in overweight and obese individuals, and improved insulin resistance.

Interested consumers can check out Supergut Fiber Mix at this link to the product page on the brand's website.

Stay up-to-date on our research reviews


We do not recommend ZuPOO and do not consider the supplement likely to have any benefits to gut health. We are unable to identify any effectively-dosed ingredients in this supplement for gut health, and two of the active ingredients have been shown in clinical studies to cause liver damage when taken in high doses.

There are a number of extremely strange and unscientific claims made on the ZuPOO product page, including that "toxic waste" builds up in the body and causes harm. The brand provides no proof of these claims and we consider this to be a red flag about the ethics and legitimacy of the Umzu brand.

We have not come across any medical evidence suggesting that colon cleansing via dietary supplements is beneficial to health.

We recommend that consumers avoid ZuPOO and avoid all supplements sold by Umzu. This is arguably the worst supplement we've ever reviewed on Illuminate Health.

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