Disclaimer: None of the information in this article constitutes medical advice, and is just the opinion of the writer(s). We recommend that patients follow their doctor’s guidance in regard to dietary supplements.
Ovasitol is a women's health supplement manufactured by a company called Theralogix. The brand claims that their supplement can promote healthy hormone levels, and support regular menstrual cycles and fertility.
But does Ovasitol contain research-backed ingredients for promoting healthy menstrual cycles and hormone levels? Does it contain any unhealthy ingredients? Will it cause side effects? And is Ovasitol proven to cause weight loss?
In this article we'll answer all of these questions and more, as we analyze the ingredients in Ovasitol to give our take on whether or not it's likely to be effective, and whether or not it's healthy.
We'll also discuss the potential for side effects, analyze the studies on weight loss, and compare Ovasitol to popular women's health supplements like Primal Queen to pick our winners (and losers).
Key takeaways:
- Contains ingredients shown to support healthy hormones in women with PCOS
- No side effects based on clinical trial
- We currently recommend Ovasitol
Ingredient Analysis
Ovasitol contains two ingredients: myo-inositol and d-chiro-inositol:
These are both forms of inositol, which is a compound produced naturally by the body that affects insulin function and hormones.
The dosage instructions provided by Ovasitol recommend a twice-daily use of the supplement, resulting in a 4 gram (g) daily dose of myo-inositol and a 100 milligram (mg) daily dose of d-chiro-inositol.
This combination of active ingredients has been shown to support women's health in research studies.
A 2019 clinical trial reported that the two forms of inositol at the exact same ratio as in Ovasitol (40:1) restored ovulation in five out of eight women with polycystic ovary syndrome (PCOS), and increased progesterone levels by nearly 50x.
A 2022 clinical trial found that myo-inositol and d-chiro-inositol improved menstrual regularity in women with PCOS. Average menstrual cycle length decreased from 124.5 days to 57.8 days, and insulin resistance improved.
84% of women on inositol regained periods compared to 100% of women on oral contraceptives.
A clinical trial published in the European Review for Medical and Pharmacological Sciences evaluated the effects of myo-inositol in insulin-resistant women.
The researchers found that myo-inositol had “significantly beneficial” effects on progesterone levels (a sign of fertility) and on pregnancy rates. The group taking myo-inositol were also taking 400 micrograms (mcg) of folic acid, so we can’t attribute these results to inositol alone.
There are no inactive ingredients at all in Ovasitol, which is good for consumers because many supplements contain inactive ingredients like refined sugar and artificial flavors that we consider to be unhealthy.
Overall, we consider Ovasitol likely to support healthy hormonal function and fertility in women with PCOS, and we currently recommend this supplement.
Women with PCOS may benefit from speaking with their doctor about Ovasitol prior to trying more invasive or risky treatments.
We haven't come across much convincing medical evidence that the two ingredients in Ovasitol are beneficial for women without PCOS.
Does Ovasitol Cause Side Effects?
Ovasitol claims that their supplement is unlikely to cause any side effects.
In an FAQ section on their site, the brand states the following: “There are no expected side effects from Ovasitol.”
Medical research suggests that this claim is accurate.
A 2011 meta-study on inositol found that only the highest dose of inositol (which was 12 g per day, or 3x the amount in Ovasitol) caused side effects, and even then the side effects were minor such as nausea and gas.
Even in women with PCOS, there don't appear to be any side effects.
A medical study published in the International Journal of Endocrinology found that 4,000 mg of myo-inositol (the exact dose and type in Ovasitol) caused no side effects compared to a placebo group:
“No relevant side effects were present among the patients.”
Overall, we do not expect Ovasitol to cause side effects, and this supplement has one of the more favorable safety profiles of any women's health supplement we've reviewed to date on Illuminate Health.
Does Ovasitol Cause Weight Loss?
Consumers are often curious about whether Ovasitol can cause weight loss.
Inositol helps regulate insulin sensitivity, and we know from previous medical research that dysregulated insulin sensitivity is associated with weight gain.
It logically follows that normalizing insulin sensitivity through supplementation of inositol could theoretically cause weight loss in overweight adults, if unregulated insulin sensitivity was a contributor to their obesity.
Medical research suggests that Ovasitol may cause weight loss in overweight adults.
A 2019 clinical trial on overweight and obese women with PCOS found that myo-inositol supplementation combined with dietary changes caused greater weight loss than dietary changes alone. The dosage used in the study was exactly the same dosage in Ovasitol (4 g).
A separate study on overweight women without PCOS reported similar efficacy.
Over a 12 month period, supplementation with inositol caused a 5% decrease in body mass index (BMI), compared with a negligible difference in a control group.
These results suggest that Ovasitol may be effective for moderate weight loss in overweight women with or without PCOS.
Ovasitol vs. Popular Women's Hormone Supps
Here's how Ovasitol compares to other popular women's health supplements with a hormone focus, in terms of formulation quality, in our opinion:
Hormone Harmony
Contains research-backed active ingredients like fennel seed, which is clinically shown to to reduce menopausal symptoms and improve women's sex drive.
We consider the clinical backing for Ovasitol to be superior, and consider the brand to be more reputable, because the Hormone Harmony website contained several questionable marketing claims upon our last review.
Winner: Ovasitol
Primal Queen
This supplement contains no ingredients that we can find research backing for in regard to women's health, as we documented in our is Primal Queen legit article.
Ovasitol has clinical backing and is much more likely to be effective.
Winner: Ovasitol
Pink Pussycat Pill
Company received FDA Warning Letter related to a hidden drug ingredient.
Ovasitol is the safer choice.
Winner: Ovasitol
What Does Ovasitol's Certification Mean?
Ovasitol is NSF certified, which is a sign of a quality brand.
The NSF is a non-profit organization that analyzes both quality control metrics of manufacturers (like facility inspections for sanitation) and quality control metrics for products (like contaminant levels and label accuracy).
Put simply, a supplement that’s NSF certified is less likely to be contaminated.
This is an important consideration in the US supplement market.
In January of 2020, over 800 supplement brands were forced to recall their products by the Food and Drug Administration (FDA) due to failures of good manufacturing practice which may have resulted in tainted supplements.
All things being equal, we would recommend an NSF-certified supplement over a supplement in the same category that's not NSF-certified.
Ovasitol Pros and Cons
Pros:
- Effective formulation
- No unhealthy inactive ingredients
- Research-backed dosage
- May be especially effective for women with PCOS
- Unlikely to cause side effects
- Healthier than competitors
- NSF-certified
Cons:
- We can't find clinical studies on this specific supplement
