SeroVital Review: Can Pills Reverse Signs of Age?

SeroVital Review: Can Pills Reverse Signs of Age?


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SeroVital is an anti-aging supplement brand marketed to women. It’s owned by a company called SanMedica, which maintains this product line can “reverse the signs of aging.”

But has SeroVital actually been shown in research studies to reverse the signs of aging, or is this just a marketing claim? Does this supplement contain research-backed ingredients that can reduce the signs of aging? Does it contain any questionable additive ingredients? And how do actual users rate and describe its effects?

In this review we’ll address all of these questions and more, as we analyze the ingredients in SeroVital ADVANCED and SeroVital HGH based on medical studies to give our take on whether these supplements are likely to be effective.

We’ll evaluate the clinical trial on SeroVital, feature unsponsored customer reviews, and provide a cost comparison to show which retailer sells SeroVital supplements for the best prices.

Ingredient Evaluation – SeroVital ADVANCED

SeroVital HGH ingredients

SeroVital Advanced consists of two separate supplements: an “Evening Blend” and a “Morning Blend.” The Supplement Facts Panel above is from the Evening Blend.

L-lysine and l-arginine are amino acids. We haven't found any medical studies establishing that either amino acid is effective for measurably improving skin quality or reducing visible signs of aging when taken orally.

Oxo-proline is an amino acid derivative and we can’t find any research suggesting it’s effective for anti-aging or skin.

Fermented l-cysteine extract is a strange choice for an anti-aging formulation in our opinion. We can’t locate any medical studies suggesting this would be effective against aging. 

Finally, we were unable to find any research suggesting l-glutamine or schizonepeta powder are effective anti-aging ingredients.

To the credit of the brand, they have updated their formulation to remove two questionable additive ingredients that were included when we first reviewed this supplement: candurin silver fine, and titanium dioxide. 

We can't find any safety data on candurin silver fine, and titanium dioxide has been banned for use as a food additive by several regulatory agencies as we'll explain in more detail in the next section of this article.

We do not currently recommend this supplement because we are unconvinced of its potential to have an anti-aging effect, but it does not in our view have any unhealthy ingredients.

But how do the ingredients in the Morning Blend stack up? We’ll evaluate that supplement in the next section of this article.

Morning Blend Evaluation

SeroVital Morning Blend ingredients

The ingredients in SeroVital ADVANCED Morning Blend are shown above.

Vitamin C and Vitamin B2 are part of a blend of vitamins and minerals included in this supplement, in some cases at high doses (zinc is included at more than 100% of the Daily Value).

Taking high doses of supplemental vitamins and minerals without evidence of a deficiency in those vitamins and minerals may have negative health effects.

In 2022, a wellness company had to recall some of their products from the Canadian market because they were causing vitamin overdose in some customers, according to the CBC.

We haven’t come across any evidence that vitamin and mineral blends have an anti-aging effect.

The remaining active ingredients are included in a proprietary (prop) blend with a total dosage of 1,016 milligrams (mg), which only equates to a 92 mg average ingredient dose.

Collagen is clinically shown to improve visible signs of aging, but the minimum effective dose of collagen for skin is 2,500 mg in our view.

A 2019 medical review analyzed 11 clinical trials on collagen for skin, and the minimum dose used in any of the trials was 2,500 mg. This is a 27x higher dose than the average ingredient dose in SeroVital's prop blend.

Chlorella, which is the first-listed active ingredient in this formulation, may be an effective anti-aging ingredient. 

A clinical trial published in the Journal of Food Biochemistry found that a drink containing chlorella caused favorable metabolic changes such as reduced inflammation, reduced oxidative stress and improved immune response which the study authors suggested combined for an overall anti-aging effect.

Hyaluronic acid was effective for improving skin moisture in a clinical trial at a dose of 120 mg per day, so this ingredient may be effectively dosed in SeroVital ADVANCED (given that 120 mg is close to the average ingredient dose in this blend).

There are two inactive ingredients in this formulation that we consider questionable from a health perspective.

Titanium dioxide is banned for use as a food additive in the EU over toxicity concerns, and California’s assembly recently passed a bill to ban use of this ingredient in food by 2025.

Talc is a mineral that was associated with increased risk of stomach cancer in a 2019 medical review.

Overall, we consider Morning Blend more likely to be effective than Evening Blend for anti-aging, given its multiple research-backed active ingredients.

However, we don’t currently recommend this supplement due to the inclusion of titanium dioxide and talc.

People Try SeroVital

A TikTok creator named Shawna shared her experienced after using SeroVital for 90 days in an unsponsored review:

@shawnaflies Overdue SeroVital update!! #womenover40 #honestreview #ladies #update #premenopausal #gettingoldersucks #flightattendant #tmi #hormones ♬ original sound - Shawna

A YouTube creator named “beautyAT50” shared her experience using SeroVital HGH:

Does SeroVital Increase HGH?

To this point in the article, we have addressed the ingredients in SeroVital ADVANCED, which is a two-part supplement (Morning Blend and Evening Blend).

But the company also sells a supplement simply called SeroVital that has the exact same active ingredients as the Evening Blend, but is marketed differently.

The company claims that this supplement can increase human growth hormone (HGH) levels.

This supplement also contains the same active ingredient formulation (down to the 2.9 g total dose) as GF9, another supplement sold by the same parent company, called SanMedica.

The clinical trial on which the maker of SeroVital relies to support claims about HGH increases does show that the supplement transiently increases HGH, but does not show that the supplement increases HGH long-term.

The research firm behind the study, called Sierra Research Group LLC, has the exact same registered address as SeroVital according to Zoominfo.

The clinical trial did show that HGH levels improved significantly after participants consumed the supplement, but the trial had a relatively short time frame (120 minutes total). We also know from medical studies that protein consumption alone can stimulate HGH release.

We have not come across any convincing medical evidence that SeroVital will improve HGH levels long-term, so this is not a supplement we currently recommend.

It’s also unclear whether taking dietary supplements that transiently increase HGH have any anti-aging effect.

Just because younger people have higher levels of HGH than older people, it does not necessarily follow that adjusting one biomarker (in this case, HGH) to transiently mirror that of a younger population has an anti-aging effect.

We have not come across any clinical studies establishing that SeroVital directly reduces biological markers of aging (like telomere length).

But does SeroVital cause side effects? We’ll discuss that in the next section of this article.

Does SeroVital Cause Side Effects?

Since SeroVital was studied in a clinical trial, it’s easier to assess the risk of potential side effects than for most supplements.

Only one patient in the trial reported minor adverse effects, and the study authors concluded that those effects were due to the process of giving blood (which can cause nausea and lightheadedness in those with a phobia), rather than due to the supplement itself.

The FAQ page on the SeroVital website does not mention any risk of serious side effects, but suggests that consumers consult with a physician about their risk of side effects, which is the most legitimate response, and for which we commend the brand.

Overall, we do not consider SeroVital likely to cause side effects in otherwise healthy individuals based on the results from the clinical trial, and based on its ingredients.

Where to Buy SeroVital for the Best Price

SeroVital is sold at a variety of online retailers. Here’s a price breakdown at the time of updating this article:

SeroVital

GNC: $99.99 (free shipping, link)

Amazon: $99 (free shipping, link

Brand website: $99 (free shipping, link)

SeroVital ADVANCED

GNC: $119.99 (free shipping, link)

Amazon: $119 (free shipping, link)

Brand website: $119 (free shipping, link)

SeroVital is currently around 1% cheaper on Amazon and the brand’s website than on GNC.

Real Customers Review SeroVital

In our opinion, Amazon is a better resource for unbiased customer reviews than a brand’s website.

SeroVital has been reviewed over 3,000 times on Amazon, and has an average customer review rating of 4.2 out of 5 stars at the time of updating this article.

The top positive review from a verified purchaser comes from a user named “Debbie Santini” who gives the product a 5/5 star rating, and claims to have experienced a beneficial effect:

"I like that with eating right and daily exercise, this product works, I have more energy, great mussel tone. My skin is clearer and I look youthful."

The top negative review from a verified purchaser is written by a user named “Ms. Jessie Jessersin” who gives the product a 1/5 star rating, and claims that it caused side effects:

“In the first week, this product made me feel extraordinarily fatigued. By the second week I started to have mild bloating and by the third week I looked like I was six months pregnant. I went to the doctor who referred me to a gastroenterologist. We have since arrived at the conclusion that the elevated levels of HGH caused a common condition, called HGH gut.”

SeroVital has an average review rating of 1.85 out of 5 stars on the Better Business Bureau (BBB) website, but the company does respond to the majority of negative reviews at the time of updating this article.

SeroVital currently has an average review rating of 3.8 out of 5 stars on Facebook.

SeroVital ADVANCED currently has an average review rating of 4.4 out of 5 stars on Google.

Pros and Cons of SeroVital

Here are the pros and cons of SeroVital as a brand in our opinion:

Pros:

  • Backed by clinical trial
  • Should increase HGH levels transiently
  • Evening Blend has clean additives
  • Mostly positive Amazon reviews

Cons:

  • Questionable anti-aging efficacy
  • Expensive
  • Clinical trial funded by company with same registered address as supplement brand
  • Morning Blend contains titanium dioxide
  • Morning Blend contains talc
  • We can’t find any evidence that transiently increasing HGH improves health
Stay up-to-date on our research reviews

Conclusion

SeroVital was shown in a clinical study to increase HGH levels after 120 minutes.

However, we can’t find any evidence that increasing HGH levels transiently has an anti-aging effect.

Further, the company that funded the clinical trial has the exact same registered address as SeroVital, raising obvious questions about bias.

We do not recommend this supplement, since we did not find proof that it increases HGH levels long-term.

Protein and amino acids have already been shown in clinical trials to transiently increase HGH levels, but we don't know if SeroVital transiently increases HGH levels beyond that of a regular protein shake.

The Morning Blend of SeroVital ADVANCED contains two inactive ingredients that may have questionable effects on human health: titanium dioxide (which is banned in the EU for use as a food additive), and talc (which was associated with increased risk of stomach cancer in at least one medical review referenced in this article).

SeroVital Morning Blend does contain some research-backed active ingredients for anti-aging, so for consumers intent on purchasing SeroVital, we recommend choosing SeroVital ADVANCED (which contains the Morning Blend) rather than SeroVital.

Amazon and the brand’s website currently have slightly better prices on SeroVital than GNC.