SeroVital is a brand targeted to women over the age of 45, which makes topical and supplement products claiming to reverse visible signs of aging.
In this review we’ll analyze the ingredients in SeroVital Advanced and SeroVital HGH based on medical research to determine whether the products are likely to be effective or not.
SeroVital Advanced Review
This product is unbelievably expensive at $119 for 30 servings, so we’d expect a premium formulation, which at first glance this product doesn’t seem to deliver.
SeroVital Advanced consists of two separate products, an “Evening Blend” and a “Morning Blend.”
Evening Blend Review
The Evening Blend contains a 2.9 gram (g) proprietary (prop) blend. If you’ve read any of our previous reviews on products with prop blends, like our Golo review, you’ll know why we distrust companies that use these: it’s a deceptive way to publish the ingredients list.
Prop blends allow companies to publish the dosage of the entire blend without publishing the dose of each individual ingredient. This prevents consumers and researchers (like us) from analyzing each ingredient to determine if it’s effectively dosed.
The first two ingredients, l-lysine and l-arginine, are amino acids. We don’t understand why these would be included in an anti-aging product because there’s little if any research we could find on their effectiveness for skin quality.
We were able to locate one single study on either of these ingredients for skin improvements, which found that l-arginine may be therapeutic for dry skin conditions, but it was an in vitro (test tube) study, which is much less reliable than a study on real human patients. We’ll assume both of these ingredients are ineffective for anti-aging.
Oxo-proline is an amino acid derivative and we can’t find any research suggesting it’s effective for anti-aging or skin.
Fermented l-cysteine extract is another strange choice for an aging formulation. We can’t locate any medical studies suggesting this would be effective for aging. Perhaps the formulators got confused with N-acetyl-cysteine (NAC), which does have some preliminary research suggesting it may be therapeutic for age-related degeneration, but the two compounds are different.
By this point you’re probably unsurprised to read that we didn’t find any research at all suggesting l-glutamine or schizonepeta powder are effective anti-aging treatments.
This “Evening Blend” is one of the worst formulations we’ve ever reviewed, with not one of the ingredients appearing to be effective for the marketing claims of anti-aging based on medical research.
Morning Blend Review
SeroVital’s Morning Blend contains some vitamins and minerals. We don’t know of any research suggesting that taking a blend of vitamins and minerals is effective for anti-aging, and SeroVital publishes no research or explanation of the seemingly random doses of these ingredients so we’ll assume they’re ineffective and superfluous.
We don’t understand why supplement companies contain random blends of vitamins and minerals without explanation, but it’s common in the industry. In our Umzu supplements review, we explained that taking minerals without a deficiency serves no biological purpose and may be harmful. Minerals should be supplemented based on a documented need from test results; not randomly dosed.
The second part of Morning Blend is another prop blend with a total dosage of 1,016 mg. Barely over 1 g is a small dose for this many ingredients, and it appears the company is adding small amounts of exotic ingredients to make their Supplement Facts label look more impressive, which is again unfortunately common in the industry.
This blend does at least appear to have a few effective ingredients for aging: collagen peptides, keratin peptides and hyaluronic acid. But they’re almost certainly too low of a dose to be effective.
The maximum effective dose of collagen for skin is 10 g based on medical research, and this entire prop blend of 11 ingredients contains barely over 1 g total. That averages out to less than 100 mg per ingredient.
Ingested hyaluronic acid was effective for improving skin moisture in a medical trial at only 120 mg/day, so perhaps this is effectively dosed but we will never know for sure since SeroVital uses a prop blend. Usually manufacturers list ingredients in a prop blend by relative dosage, so the fact that this ingredient is very last on the list means it’s likely underdosed in our opinion.
This product is better-formulated than the Evening Blend since at least a few ingredients are likely to be effective (even if their dosages aren’t), but that’s a low bar since the previous blend was the worst anti-aging supplement we’ve ever reviewed.
We don’t believe this is an effective formulation for anti-aging.
Questionable Filler Ingredients
The Morning Blend contains an ingredient called “candurin silver fine” which we’ve never seen listed on an ingestible product. It appears to be an artificial colorant.
The Evening Blend contains talc as a filler ingredient which is also very unique and questionable for an ingestible supplement. Medical research has proven that talc (even without asbestos) is associated with stomach cancer when ingested. Even if the amounts in SeroVital are miniscule, there is just no reason for this to be in a consumable product.
SeroVital HGH Review
SeroVital uses the exact same product and formulation in their HGH supplement as in the Evening Blend of SeroVital Advanced, so we don’t need to publish the Supplement Facts label again.
This product uses the exact same active ingredient formulation (down to the 2.9g dose) as GF9, another supplement claiming to drastically improve growth hormone levels. Both companies have the exact same company address according to ZoomInfo, which is somewhat sketchy.
The one study that SeroVital cites to prove their product works has significant methodological issues which we explained in detail in our GF9 review (because that one study was used to back their product too).
Basically, a company called Sierra Research Group LLC funded the study and exists in the same city as SeroVital and GF9 (which are likely run by the same person because no public team is listed for either company and they’re operated out of the exact same address).
Sierra Research Group claimed no conflict of interest in the study funding section, but we don’t agree with that statement.
As we asked in our GF9 review, “Is it a massive coincidence that an LLC with no website or public information would decide to spend time and money publishing a favorable study for a company in the same city, or is it likely that there is a business arrangement between the two entities? I’ll leave you the reader to decide.”
We don’t accept the study as legitimate due to the misaligned incentives, and we don't believe SeroVital HGH is likely to be effective for long-term HGH improvements.
Better Anti-Aging Alternatives
For skin specifically, we believe there is no more effective and cost-efficient supplement than collagen.
There’s significant medical research proving collagen can improve skin and even reduce signs of aging when consumed orally.
We recommend 10 g daily of an unflavored collagen on an empty stomach is the maximally effective dose based on medical studies. Of course speak with your doctor before beginning any new supplement, but collagen is very benign. Its levels decrease in the body as we age which is why it can be so effective as an oral supplement.
For whole body anti-aging and physical health maintenance, the compound with the most fascinating medical research is called nicotinamide adenine dinucleotide (NAD+). This compound has been shown not only to extend lifespan in animal trials but also to improve overall metabolism. A clinical review of NAD+ concluded it was a promising target for age-related disorders, but we need more research on its safety and long-term effects.