Does Inositol Improve Sleep? A Research Review

Does Inositol Improve Sleep? A Research Review


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Inositol is a sugar that’s naturally produced by the body, but that can also be found in foods and taken in an isolated form as a supplement. Many health websites and influencers online suggest that inositol can improve sleep.

But is there any research backing these claims, or are they just a marketing push to sell inositol? Are there any side effects associated with inositol use? How do real users describe the effects of inositol on their sleep? And what retailer sells inositol for the best price?

In this article we’ll answer all of these questions and more, as we analyze medical studies on inositol for sleep to give our take on whether the supplement is likely to be effective, or if it’s a waste of money.

We’ll discuss side effects, feature unsponsored user reviews of inositol for sleep, and provide a cost breakdown to show which retailer sells this supplement the cheapest.

Does Inositol Improve Sleep?

There have been clinical trials analyzing the effects of inositol on sleep.

A 2022 clinical trial tested the effects of inositol supplementation on sleep in pregnant women. Inositol not only improved sleep quality, but also sleep duration.

A clinical trial published in the Neuropsychobiology journal indirectly suggests that inositol supplementation may be effective for supporting sleep. The researchers found that higher levels of circulating inositol in the brain equated to greater daytime sleepiness in adolescents.

A medical review published in the Biomedicines journal reports that inositol levels have been clinically shown to be lower in patients with sleep disorders.

Based on the available research, we consider inositol potentially effective for improving sleep quality. However, we could only find one clinical trial directly testing inositol on sleep quality, and this trial was in pregnant women, which doesn’t necessarily make it reflective of the broader population.

More research is needed to conclusively state that inositol is an effective sleep supplement.

But before reviewing the safety of inositol, we’ll feature some unsponsored user reviews in the next section.

We Tried Inositol Ourselves

One of our product testers named Jodie Steinberg used an inositol supplement before sleep for 30 days. Here's her experience: 

The product was easy-to-use and the supplement was flavorless.

I have trouble sleeping, and have taken numerous sleeping aids over the years, so I am very familiar with what works and what does not.

These did not help with my sleep at all. I found no difference in my ability to stay asleep or fall back asleep upon waking which are my two biggest issues with sleep.

I did not experience any side effects or any negative effects at all.

Overall, I would rate this product 0/10 for sleep purposes. It might have other helpful uses but I was solely judging it on its ability to aid with sleep.

I do not plan to purchase this again.

Does Inositol Cause Side Effects?

Inositol may cause side effects in some individuals. However, these side effects appear to be relatively minor.

A 2011 medical review on the side effects of inositol documented that only the highest daily dose (12 grams per day) caused side effects, and the side effects reported were mild: nausea, gas and diarrhea.

A meta-analysis on inositol supplementation in women with PCOS published in the Endocrine Connections journal reported no serious side effects.

Based on the available research, we do not consider inositol supplementation likely to cause side effects in otherwise healthy adults. 

But what retailer sells inositol for the best price-per-serving? We’ll provide a cost breakdown in the next section.

Real People Try Inositol for Sleep

A YouTube creator named Bret Dallas discusses his experience taking inositol as a supplement:

A neuroscientist and health influencer named Andrew Huberman discussed the effects of inositol on his sleep quality:

Where to Buy Inositol for the Best Price

Amazon typically has the cheapest bulk prices on single-ingredient supplements.

Servings per brand vary significantly, so we’ll simplify the cost comparison by sharing the price-per-gram of inositol:

Life Extension: $0.16 (link)

NOW Supplements: $0.06 (free shipping, link to official Amazon listing)

Nutricost: $0.06 (free shipping, link to official Amazon listing)

At the time of publishing this article, Nutricost and NOW Supplements provide the best cost on inositol.

Our Clean Sleep Picks

There are sleep products with ingredients and materials clinically shown to improve sleep quality.

Sleep Mode from Bulletproof is our top sleep supplement pick.

It contains melatonin which is arguably the most well-studied sleep inducer, along with l-ornithine which is an amino acid that's clinically shown to reduce cortisol and improve sleep quality at the same dose as in Sleep Mode.

Interested consumers can check out Sleep Mode at this link to the product page on Bulletproof's official website, where it currently retails for under $30.

Nolah Weighted Bamboo Blanket is a great option for consumers who prefer non-supplement solutions for sleep. Weighted blankets are clinically shown to improve sleep quality in both older adults and in children, and early research suggests they may also reduce anxiety.

Interested consumers can check out Nolah Weighted Bamboo Blanket at this link to the product page on the official brand website, where it’s currently retailing for under $100.

Manta Sleep Mask is the most cost-effective sleep solution, because it’s only $35 and will last for years. A 2021 clinical trial found that eye mask and ear plug use improved sleep quality in ICU patients. Manta’s mask comes with ear plugs.

We can't locate any medical studies on sleep mask use in healthy patients, but it seems logical that the same effects would hold given that light exposure during sleep negatively impacts sleep quality.

Interested consumers can check out Manta Sleep Mask at this link to the product page on the official brand website.

Stay up-to-date on our research reviews

Conclusion

Inositol appears to be a non-toxic supplement that can support optimal sleep.

We don’t currently recommend inositol as a sleep supplement because we could only find one clinical trial proving it to be effective, and that trial was on a specific population segment so it doesn’t necessarily apply to the average consumer.

If more research emerges in the future proving inositol to optimize sleep quality and duration, we’ll consider recommending this supplement in our sleep-related articles.

Most of the user reviews on inositol supplementation that we came across while researching this article were positive.

At the time of publishing this article, NOW Supplements and Nutricost have the best prices on inositol.