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{"id":556350079049,"title":"Total Restore Review: Why It's Poorly-Dosed","created_at":"2022-03-29T00:28:02-04:00","body_html":"\u003cscript type=\"application\/ld+json\"\u003e\/\/ \u003c![CDATA[\n{\n \"@context\": \"https:\/\/schema.org\",\n \"@type\": \"Article\",\n \"headline\": \"Total Restore Review: Why It's Poorly-Dosed\",\n \"keywords\": \"total restore, total restore review, total restore reviews, gundry md, gundry md total restore, total restore gundry\",\n \"description\": \"Our MD and research team reviews the ingredients in Total Restore based on published medical research to determine if it’s likely to be effective and safe. We also highlight some questionable health claims made by the brand.\",\n \"url\": \"https:\/\/illuminatelabs.org\/blogs\/health\/total-restore-review\",\n\"author\": {\n \"@type\": \"Person\",\n \"name\": \"Taylor Graber MD\",\n \"url\": \"https:\/\/illuminatelabs.org\/pages\/taylor-graber\",\n \"sameAs\": \"https:\/\/www.linkedin.com\/in\/taylor-j-graber-md-81351642\/\",\n \"jobTitle\": \"Content Partner\",\n \"knowsAbout\": \"medicine, health, anesthesiology, iv therapy, science, drugs, pharmaceutical, medical research, scientific research, medical journals, entrepreneurship, healthcare, orthopedic surgery, biomedical engineering\",\n \"alumniOf\": {\n \"@type\": \"EducationalOrganization\",\n \"name\": [\n \"University of California San Diego\",\n \"Arizona University\",\n \"University of Arizona College of Medicine\"\n ]\n },\n \"memberOf\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n }\n},\n\"contributor\": {\n \"@type\": \"Person\",\n \"name\": \"Calloway Cook\",\n \"url\": \"https:\/\/illuminatelabs.org\/pages\/calloway-cook\",\n \"sameAs\": \"https:\/\/www.linkedin.com\/in\/calloway-cook\/\",\n \"jobTitle\": \"President\",\n \"knowsAbout\": \"entrepreneurship, dietary supplements, herbal supplements, eCommerce, medical research\",\n \"alumniOf\": {\n \"@type\": \"EducationalOrganization\",\n \"name\": \"S.I. 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We previously reviewed another supplement by Gundry MD called \u003c\/span\u003e\u003ca href=\"https:\/\/illuminatelabs.org\/blogs\/health\/bio-complete-3-review\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eBio Complete 3\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e, which we found to be very poorly formulated, so we’re curious if this product is superior.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIn this article we’ll review the ingredients in Total Restore based on published medical research to determine if it’s likely to be effective and safe. We’ll also highlight some questionable health claims made by the brand.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eQuestionable Ingredient Dosages \u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAt first glance, several of the active ingredients in Total Restore appear extremely underdosed. The product contains 7 milligrams (mg) of \u003c\/span\u003e\u003cb\u003emagnesium\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e. This is only 2% of the Daily Value (DV), and is such a low dose as to be pointless in our opinion. It’s less than 25% of the magnesium found in a single banana, according to government resource \u003c\/span\u003e\u003ca href=\"https:\/\/fdc.nal.usda.gov\/fdc-app.html#\/food-details\/173944\/nutrients\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eFoodData Central\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe supplement contains 3 mg of \u003c\/span\u003e\u003cb\u003eberberine\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e, which is an even more absurd dosage. This compound has been studied extensively in animal studies, and a \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32105754\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emedical review\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e shows that the human equivalent dosage is greater than 1000 mg\/day, or over 300x the amount in Total Restore. The same review even states that oral bioavailability is very low in humans even at a dose of 400 mg, which is more than 100x the dose in this supplement.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eMarshmallow root powder \u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003eis another ingredient that appears underdosed. We can’t locate any evidence that this botanical compound is beneficial for gut function in humans in any case, but a \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31770755\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emeta-study\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e of its effects for reducing cough used doses multiples higher than that in Total Restore.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe lowest human dose in the linked study is 40 mg, and doses up to 300 mg are reported. The dose in Total Restore is 10 mg, so we will consider this another ineffective and underdosed ingredient.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe final ingredient we want to call out for its dosage is \u003c\/span\u003e\u003cb\u003eVitaBerry\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e, which is a patented berry blend with a 22 mg dose in Total Restore. For reference, one single strawberry is 18 grams (g), which equates to 18,000 mg. One single strawberry has a dose 800x higher than this blend of 6 different berry powders. We find this to be a pointless ingredient inclusion due to the dose.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eActive Ingredient Review\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cb\u003eL-glutamine\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e is the ingredient in Total Restore with the highest dose, but it also appears significantly underdosed based on medical studies. This compound is typically supplemented for sports performance rather than gut function. A \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25933498\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eclinical trial\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e on l-glutamine supplementation for improving gut function in overweight adults used a dose of 30 g, which is over 100x the amount in Total Restore.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eA separate \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32992440\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003estudy\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e broke glutamine supplementation into “low,” “medium” and “high” groups. The “low” dosage was 0.3 g per kilogram (kg) of fat-free mass, which equates to around 50 g for an average weight man. This is a dose over 200x the amount in Total Restore.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe second active ingredient in this supplement is \u003c\/span\u003e\u003cb\u003eN-Acetyl-D-Glucosamine\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e, which is a derivative of glucose. It appears to be used primarily for joint pain rather than gut function. We can’t identify a single medical trial suggesting that this compound is beneficial to the gut function of adults as a supplement, so we will consider it an ineffective ingredient.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eGrape seed extract\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e has some potential benefits to gut function in animal studies, but we can’t find proof in human trials that it’s effective. One trial found that grape seed extract at 300 mg\/day was effective in reducing body weight in overweight individuals. The dose in Total Restore is only 58 mg, so we’ll consider this another ineffective ingredient.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eLicorice root\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e is included in this supplement at a dose of 54 mg. Gundry MD uses the raw powder form of this botanical ingredient, but most of the medical research on this compound uses the extracted form, which is more concentrated.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eA \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3123991\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emedical study\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e found that a 150 mg daily dosage of licorice root was effective in reducing abdomen pain, but the extract form was used, and that dose (even at a more concentrated form) is still 3x the dose of Total Restore.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIt seems to us like Gundry MD doesn’t even bother to review medical research on the appropriate dosage of the ingredients they include in their supplements. They simply choose a botanical compound which may be effective, and then add a seemingly random and insignificant amount of it to their overall formulation.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThis is arguably the worst product formulation we’ve ever reviewed. While some of the ingredients themselves may be effective, every single ingredient that we reviewed appears to be dosed too low to have a proven effect.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eQuestionable Health Claims\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Total_Restore_Health_Claims.png?v=1648528905\" alt=\"Total Restore questionable health claims\" style=\"display: block; margin-left: auto; margin-right: auto;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eLike they did with their Bio Complete 3 supplement, Gundry MD makes bold proclamations on their site about the health benefits of Total Restore. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe brand claims that this supplement “boosts feelings of energy and focus, and may even help calm your mood.” They also claim the product helps support food cravings and helps fight unwanted body weight.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eThere are, of course, zero citations or proof for these claims. It’s just unethical marketing. GundryMD has not funded any medical trials proving their products work, nor do they even link out to any existing medical research suggesting their products work.\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eBetter Alternative\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eConsumers looking to optimize gut function would be better off choosing whole foods rich in probiotics. We know from \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31315227\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eextensive medical research\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e that dietary patterns affect the microbiome, and influence the ratio of “good” to “bad” bacteria in the gut.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eKefir\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e is a fermented milk beverage that’s rich in probiotics. It used to be found mainly in international food markets, but now has crossed over into the mainstream and can be found in many commercial grocery stores. We recommend buying kefir sourced from pastured animals, as it will be more nutrient-rich and likely higher in probiotics than a product sourced from conventional animals.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eNatto\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e is another healthy whole food option that can help restore the gut. This fermented bean dish is a Japanese cuisine that has been studied in various medical publications, and a \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6723656\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emedical review\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e found that it increases levels of beneficial bacteria in the gut and regularized stool frequency.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eConclusion\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eTotal Restore is a terribly-formulated supplement. We recommend that you avoid it, and we recommend that consumers avoid Gundry MD as a brand entirely as they seem totally incompetent based on the two products of theirs that we’ve reviewed.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe were unable to identify a single active ingredient that was effectively dosed based on medical research. We recommend that instead of adding insignificant amounts of many ingredients, the brand just uses a few ingredients and actually includes an appropriate dose.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eEating whole foods rich in probiotics is likely to be much cheaper, more effective and healthier than taking Total Restore. Natto and kefir are two options for natural probiotics, but there are many more including regular Greek yogurt.\u003c\/span\u003e\u003c\/p\u003e","blog_id":49281925193,"author":"Calloway Cook","user_id":26601750601,"published_at":"2022-03-29T10:46:04-04:00","updated_at":"2022-03-29T10:46:04-04:00","summary_html":"We review the ingredients in gut supplement Total Restore based on published medical research to determine if it’s likely to be effective and safe. We also highlight some questionable health claims made by the brand.","template_suffix":"","handle":"total-restore-review","tags":"_related:gut-health"}

Total Restore Review: Why It's Poorly-Dosed

Total Restore Review: Why It's Poorly-Dosed


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Read our Editorial Guidelines to learn more about what makes our site the premier resource for online health information.
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Read our Editorial Guidelines to learn more about what makes our site the premier resource for online health information.


Read our Editorial Guidelines to learn more about what makes our site the premier resource for online health information.

Total Restore is a supplement to support optimal gut function sold by Gundry MD. We previously reviewed another supplement by Gundry MD called Bio Complete 3, which we found to be very poorly formulated, so we’re curious if this product is superior.

In this article we’ll review the ingredients in Total Restore based on published medical research to determine if it’s likely to be effective and safe. We’ll also highlight some questionable health claims made by the brand.

Questionable Ingredient Dosages 

At first glance, several of the active ingredients in Total Restore appear extremely underdosed. The product contains 7 milligrams (mg) of magnesium. This is only 2% of the Daily Value (DV), and is such a low dose as to be pointless in our opinion. It’s less than 25% of the magnesium found in a single banana, according to government resource FoodData Central.

The supplement contains 3 mg of berberine, which is an even more absurd dosage. This compound has been studied extensively in animal studies, and a medical review shows that the human equivalent dosage is greater than 1000 mg/day, or over 300x the amount in Total Restore. The same review even states that oral bioavailability is very low in humans even at a dose of 400 mg, which is more than 100x the dose in this supplement.

Marshmallow root powder is another ingredient that appears underdosed. We can’t locate any evidence that this botanical compound is beneficial for gut function in humans in any case, but a meta-study of its effects for reducing cough used doses multiples higher than that in Total Restore.

The lowest human dose in the linked study is 40 mg, and doses up to 300 mg are reported. The dose in Total Restore is 10 mg, so we will consider this another ineffective and underdosed ingredient.

The final ingredient we want to call out for its dosage is VitaBerry, which is a patented berry blend with a 22 mg dose in Total Restore. For reference, one single strawberry is 18 grams (g), which equates to 18,000 mg. One single strawberry has a dose 800x higher than this blend of 6 different berry powders. We find this to be a pointless ingredient inclusion due to the dose.

Active Ingredient Review

L-glutamine is the ingredient in Total Restore with the highest dose, but it also appears significantly underdosed based on medical studies. This compound is typically supplemented for sports performance rather than gut function. A clinical trial on l-glutamine supplementation for improving gut function in overweight adults used a dose of 30 g, which is over 100x the amount in Total Restore.

A separate study broke glutamine supplementation into “low,” “medium” and “high” groups. The “low” dosage was 0.3 g per kilogram (kg) of fat-free mass, which equates to around 50 g for an average weight man. This is a dose over 200x the amount in Total Restore.

The second active ingredient in this supplement is N-Acetyl-D-Glucosamine, which is a derivative of glucose. It appears to be used primarily for joint pain rather than gut function. We can’t identify a single medical trial suggesting that this compound is beneficial to the gut function of adults as a supplement, so we will consider it an ineffective ingredient.

Grape seed extract has some potential benefits to gut function in animal studies, but we can’t find proof in human trials that it’s effective. One trial found that grape seed extract at 300 mg/day was effective in reducing body weight in overweight individuals. The dose in Total Restore is only 58 mg, so we’ll consider this another ineffective ingredient.

Licorice root is included in this supplement at a dose of 54 mg. Gundry MD uses the raw powder form of this botanical ingredient, but most of the medical research on this compound uses the extracted form, which is more concentrated.

A medical study found that a 150 mg daily dosage of licorice root was effective in reducing abdomen pain, but the extract form was used, and that dose (even at a more concentrated form) is still 3x the dose of Total Restore.

It seems to us like Gundry MD doesn’t even bother to review medical research on the appropriate dosage of the ingredients they include in their supplements. They simply choose a botanical compound which may be effective, and then add a seemingly random and insignificant amount of it to their overall formulation.

This is arguably the worst product formulation we’ve ever reviewed. While some of the ingredients themselves may be effective, every single ingredient that we reviewed appears to be dosed too low to have a proven effect.

Questionable Health Claims

Total Restore questionable health claims

Like they did with their Bio Complete 3 supplement, Gundry MD makes bold proclamations on their site about the health benefits of Total Restore. 

The brand claims that this supplement “boosts feelings of energy and focus, and may even help calm your mood.” They also claim the product helps support food cravings and helps fight unwanted body weight.

There are, of course, zero citations or proof for these claims. It’s just unethical marketing. GundryMD has not funded any medical trials proving their products work, nor do they even link out to any existing medical research suggesting their products work.

Better Alternative

Consumers looking to optimize gut function would be better off choosing whole foods rich in probiotics. We know from extensive medical research that dietary patterns affect the microbiome, and influence the ratio of “good” to “bad” bacteria in the gut.

Kefir is a fermented milk beverage that’s rich in probiotics. It used to be found mainly in international food markets, but now has crossed over into the mainstream and can be found in many commercial grocery stores. We recommend buying kefir sourced from pastured animals, as it will be more nutrient-rich and likely higher in probiotics than a product sourced from conventional animals.

Natto is another healthy whole food option that can help restore the gut. This fermented bean dish is a Japanese cuisine that has been studied in various medical publications, and a medical review found that it increases levels of beneficial bacteria in the gut and regularized stool frequency.

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Conclusion

Total Restore is a terribly-formulated supplement. We recommend that you avoid it, and we recommend that consumers avoid Gundry MD as a brand entirely as they seem totally incompetent based on the two products of theirs that we’ve reviewed.

We were unable to identify a single active ingredient that was effectively dosed based on medical research. We recommend that instead of adding insignificant amounts of many ingredients, the brand just uses a few ingredients and actually includes an appropriate dose.

Eating whole foods rich in probiotics is likely to be much cheaper, more effective and healthier than taking Total Restore. Natto and kefir are two options for natural probiotics, but there are many more including regular Greek yogurt.





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