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{"id":556812075081,"title":"Heal n Soothe Review: Can Enzymes Reduce Pain?","created_at":"2022-08-06T18:01:49-04:00","body_html":"\u003cscript type=\"application\/ld+json\"\u003e\/\/ \u003c![CDATA[\n{\n \"@context\": \"https:\/\/schema.org\",\n \"@type\": \"Article\",\n \"headline\": \"Heal n Soothe Review: Can Enzymes Reduce Pain?\",\n \"keywords\": \"heal n soothe, heal n soothe review, heal n soothe reviews, heal-n-soothe, heal-n-soothe reviews\",\n \"description\": \"Our research team reviews every active ingredient in Heal n Soothe based on published medical studies to determine if the supplement is safe and effective for reducing pain. We explain why we consider the brand's 'Research Section' to be questionable, and highlight real user reviews of the supplement.\",\n \"url\": \"https:\/\/illuminatelabs.org\/blogs\/health\/heal-n-soothe-review\",\n\"author\": {\n \"@type\": \"Person\",\n \"name\": \"Calloway Cook\",\n \"url\": \"https:\/\/illuminatelabs.org\/pages\/calloway-cook\",\n \"sameAs\": \"https:\/\/www.linkedin.com\/in\/calloway-cook\/\",\n \"jobTitle\": \"President\",\n \"knowsAbout\": \"entrepreneurship, dietary supplements, herbal supplements, eCommerce, medical research\",\n \"alumniOf\": {\n \"@type\": \"EducationalOrganization\",\n \"name\": \"S.I. Newhouse School of Public Communications at Syracuse University\"\n },\n \"memberOf\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n }\n},\n\"creator\": {\n \"@type\": \"Person\",\n \"name\": \"Calloway Cook\",\n \"url\": \"https:\/\/illuminatelabs.org\/pages\/calloway-cook\",\n \"sameAs\": \"https:\/\/www.linkedin.com\/in\/calloway-cook\/\",\n \"jobTitle\": \"President\",\n \"knowsAbout\": \"entrepreneurship, dietary supplements, herbal supplements, eCommerce, medical research\",\n \"alumniOf\": {\n \"@type\": \"EducationalOrganization\",\n \"name\": \"S.I. Newhouse School of Public Communications at Syracuse University\"\n },\n \"memberOf\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n }\n},\n\"editor\": {\n \"@type\": \"Person\",\n \"name\": \"DJ Mazzoni\",\n \"honorificSuffix\": [\n \"M.S.\",\n \"R.D.\",\n \"C.D.N.\",\n \"C.S.C.S.\"\n ],\n \"url\": \"https:\/\/illuminatelabs.org\/pages\/dj-mazzoni\",\n \"sameAs\": \"https:\/\/www.linkedin.com\/in\/dj-mazzoni-rd-cdn-cscs-00a33038\/\",\n \"jobTitle\": \"Medical Reviewer\",\n \"knowsAbout\": \"exercise, drugs, pharmaceutical, health, workout, strength and conditioning, nutrition, dietetics, medicine, medical research, scientific research, scientific method, healthcare, patient care, wellness\",\n \"alumniOf\": {\n \"@type\": \"EducationalOrganization\",\n \"name\": [\n \"State University of New York College Oswego\",\n \"D’Youville College\"\n ]\n },\n \"memberOf\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n }\n},\n\"image\": {\n\"@type\": \"ImageObject\",\n\"url\": \"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Heal_n_Soothe_Thumbnail.png?v=1659823674\",\n\"width\": \"3338\",\n\"height\": \"3338\"\n},\n\"citation\": [\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16673265\/\", \n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12587686\/\",\n\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8067380\/\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32122870\/\",\n\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7368679\/\",\n\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7037709\/\",\n\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4818021\/\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11710709\/\",\n\"https:\/\/journal-inflammation.biomedcentral.com\/articles\/10.1186\/1476-9255-3-6\",\n\"https:\/\/illuminatelabs.org\/blogs\/health\/instaflex-review\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34649217\/\",\n\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3918523\/\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33511486\",\n\"https:\/\/www.amazon.com\/Anti-Inflammatory-Supplement-Proteolytic-Enzyme\/dp\/B00MH4H3QQ\",\n\"https:\/\/www.fakespot.com\/product\/heal-n-soothe\",\n\"https:\/\/healnsoothe.com\/products\/141\/sp-hns\",\n\"https:\/\/www.amazon.com\/Anti-Inflammatory-Supplement-Proteolytic-Enzyme\/dp\/B00MH4H3QQ\/ref=cm_cr_arp_d_product_top?ie=UTF8\"\n],\n\"mentions\": [{\n \"@type\": \"Thing\",\n \"name\": \"protease\"\n },\n {\n \"@type\": \"Thing\",\n \"name\": \"FCCPU\"\n },\n {\n \"@type\": \"Thing\",\n \"name\": \"turmeric extract\"\n },\n {\n \"@type\": \"Thing\",\n \"name\": \"Amazon\"\n },\n {\n \"@type\": \"Thing\",\n \"name\": \"FakeSpot\"\n }\n],\n\"datePublished\": \"2022-08-06\",\n\"copyrightHolder\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n},\n\"publisher\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\",\n \"url\": \"https:\/\/illuminatelabs.org\/\",\n \"description\": \"Illuminate Labs is the most transparent supplement company in the U.S., and is a leading publisher of research-based health information.\",\n \"knowsAbout\": \"supplements, science, nutrition, exercise, health, medication, pharmaceutical, wellness, diet, weight loss, medical research\",\n \"publishingPrinciples\": \"https:\/\/illuminatelabs.org\/pages\/editorial-guidelines\",\n \"logo\": {\n \"@type\": \"ImageObject\",\n \"url\": \"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Illuminate_Labs_Logo.png?v=1641249064\", \n \"width\": 150,\n \"height\": 150\n},\n \"foundingDate\": \"2019-01-30\",\n \"Address\": {\n \"@type\": \"PostalAddress\",\n \"streetAddress\": \"50 Union Street, Unit 9\",\n \"addressLocality\": \"Northampton\",\n \"addressRegion\": \"Massachusetts\",\n \"postalCode\": \"01060\",\n \"addressCountry\": \"US\"\n},\n \"sameAs\": [\n \"https:\/\/www.instagram.com\/illuminatelabs\",\n \"https:\/\/twitter.com\/illuminatelabs\",\n \"https:\/\/www.linkedin.com\/company\/illuminate-labs-supplements\",\n \"https:\/\/www.youtube.com\/channel\/UCpgSJAsIPb-fZ25djtTxBEA\"\n ]\n }\n}\n\/\/ ]]\u003e\u003c\/script\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Heal_n_Soothe_Review_Article_Header_Image_Optimized.png?v=1659823324\" alt=\"\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan class=\"dc\"\u003eH\u003c\/span\u003eeal n Soothe, alternatively referred to as Heal-n-Soothe, is an anti-inflammatory dietary supplement. It’s manufactured by a company called Livingwell Nutraceuticals. The brand claims that it can reduce joint pain with its blend of proteolytic enzymes and botanical ingredients.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIn this article we’ll review every active ingredient in Heal n Soothe based on published medical research to determine if we believe it’s likely to be effective, or if it’s another dietary supplement that makes bold claims but comes up short.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eSystemic Enzyme Blend Review\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Heal_n_Soothe_Systemic_Enzyme_Blend_Optimized.png?v=1659823556\" alt=\"Heal n Soothe Systemic Enzyme Blend\" style=\"display: block; margin-left: auto; margin-right: auto;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe first section of Heal n Soothe’s ingredients consists of a “Systemic Enzyme Blend” with a total dosage of 750 milligrams (mg). \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThis blend contains three different types of \u003c\/span\u003e\u003cb\u003eprotease\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e, which is a digestive enzyme that breaks down protein: Protease AM, Protease 6.0 and Alkaline Protease. We cannot find any information on Heal n Soothe’s website explaining why they use three different types of this enzyme, or what the relative benefits are.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe can’t locate any research cited on Heal n Soothe’s website suggesting or proving that protease supplementation reduces pain. In fact, we identified a \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16673265\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emedical review\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e published in the \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eSeminars in Thrombosis and Hemostasis\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e journal with the following title: “Protease-activated receptors: how proteases signal to cells to cause inflammation and pain.”\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe review clarifies that some proteases that are produced by the body contribute to pain and inflammation, not necessarily exogenously supplemented proteases like those in Heal n Soothe, but we still consider this to be a bad sign.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe cannot find a single medical study suggesting that supplemental protease reduces pain.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eBromelain\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e is another active ingredient in the Systemic Enzyme Blend. This is an enzyme that’s typically extracted from pineapple. The listed dose in Heal n Soothe is 6,000,000 Food Chemical Codex Papain Units (FCCPU). It’s unclear how many mg this equates to, and Heal n Soothe does not appear to provide this information on their website.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eA \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12587686\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eclinical trial\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e published in 2002 found that supplemental bromelain reduced knee pain in patients at doses of 200 mg and 400 mg. A \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8067380\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emedical review\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e found that bromelain reduces the expression of several inflammatory markers.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe will consider this a potentially effective ingredient, though we can’t say it’s conclusively effective without understanding the dosage in mg units.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe final active ingredient in this blend is \u003c\/span\u003e\u003cb\u003epapain\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e, which is an enzyme sourced from papaya. This ingredient was found in a \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32122870\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emedical trial\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e to significantly reduce lower back pain in arthritis patients in combination with bromelain. This trial described dosage in mg, while the dosage in Heal n Soothe is described again in FCCPU. We would urge Livingwell Nutraceuticals to change their listing of dosage to mg, which seems to be the medical standard, and which would make it easier for researchers and consumers to evaluate the efficacy of their supplement.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe will consider papain potentially effective, depending on dosage.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOverall we consider this blend to be decently formulated for analgesic (pain-relieving) function. Two of the three ingredients appear to have medical backing, though we cannot evaluate if these ingredients are effectively dosed due to the way Heal n Soothe reports dosage.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eBotanical Active Ingredient Review\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Heal_n_Soothe_Botanical_Active_Ingredients_Optimized.png?v=1659823596\" alt=\"Heal n Soothe botanical active ingredients list\" style=\"display: block; margin-left: auto; margin-right: auto;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOutside of the Systemic Enzyme Blend, Heal n Soothe contains a number of active ingredients.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe highest-dose active ingredient in this section is \u003c\/span\u003e\u003cb\u003eBoswellia serrata extract\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e, at a dosage of 150 mg. This appears to be an effective dose for pain management. A \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7368679\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emedical review\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e of this herbal compound, which analyzed data from 7 individual medical trials on the topic, reported the effective therapeutic dosing range of boswellia serrata extract to be 100 - 250 mg.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eCitrus bioflavonoid complex\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e is the next-listed ingredient at a dosage of 90 mg. While these compounds have \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7037709\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003edocumented\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e analgesic effects in medical research, we cannot find any studies proving they’re effective at such a low dose. The minimum dose from the research trials in the above-linked medical review was 150 mg\/day.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eGinger root extract\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e is included at 90 mg. We consider this an ineffective and underdosed amount. One of the \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4818021\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emedical studies\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e linked to on the Heal n Soothe site states the following: “Also, the daily dosage varied from 600 to 2500 mg. Similarly, in a recent systematic review on the use of ginger in CINV, typical dosing regimens were 1–2 g of ginger.” The other \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11710709\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003estudy\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e the brand linked to used a 255 mg ginger extract dosage.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe find it to be somewhat ironic that the brand’s own citations prove the amount of ginger they used is underdosed.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eYucca\u003c\/b\u003e \u003ca href=\"https:\/\/journal-inflammation.biomedcentral.com\/articles\/10.1186\/1476-9255-3-6\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eis proven\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e to be an effective anti-inflammatory compound. We cannot find dosing recommendations so we will consider this a potentially effective ingredient inclusion.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eTurmeric\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e is another active ingredient in this formulation at a dose of 60 mg. This is a very low dose of turmeric, and Heal n Soothe uses raw turmeric (like what you’d find in a grocery store spice aisle) rather than turmeric extract, which is what most medical studies on the compound use because it’s more potent. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAs we outlined in our review of \u003c\/span\u003e\u003ca href=\"https:\/\/illuminatelabs.org\/blogs\/health\/instaflex-review\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eInstaflex\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e, which is another anti-inflammatory dietary supplement, the minimum effective therapeutic dose of turmeric extract is 1,000 mg, which is over 10x the dose of the raw, un-extracted version used in Heal n Soothe. Thus we will consider this an ineffective inclusion.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eAlpha-lipoic acid\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e also appears to be underdosed in Heal n Soothe at only 50 mg. The minimum effective dose we could find of this compound is 400 mg from a 2021 \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34649217\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eresearch trial\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAnother ingredient we would consider underdosed is \u003c\/span\u003e\u003cb\u003eDevil’s Claw root extract\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e, which is included at a dose of 30 mg in the supplement. A medical review of this herb found that it was effective for pain reduction, but the average dose used in the analyzed trials was over 1,000 mg, which is over 30x more than that in Heal n Soothe.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe final active ingredient is \u003c\/span\u003e\u003cb\u003erutin\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e, and we cannot identify any medical evidence that 30 mg of rutin is effective for reducing pain.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIt’s worth noting that Heal n Soothe contains inactive ingredients which are non-toxic and safe, which is a good sign because some supplements contain additives like added sugar and artificial dyes which may be harmful to health.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOverall we consider this to be a relatively poor formulation and we would not recommend it. While most of the ingredients do have some research backing, we believe that most of the botanical ingredients in this supplement are underdosed (sometimes significantly). The only ingredient in the botanical ingredients section that we identified as effectively dosed is boswellia serrata extract.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eQuestionable Research Studies Section\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Heal_n_Soothe_Research_Studies_Optimized.png?v=1659823621\" alt=\"Heal n Soothe research studies section of their website\" style=\"display: block; margin-left: auto; margin-right: auto;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eHeal n Soothe’s website contains a Research Studies section which we find to be effectively pointless.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThis section states that bromelain has been found to be effective for pain at a 400 mg dosage, but as we described in the previous section, the brand does not list dosage in terms of mg, so this information is useless to consumers. Further, the brand doesn’t link to the study in question so consumers have no ability to verify whether this health claim is true.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe second health claim is that turmeric can inhibit formation of an enzyme that causes inflammation and pain, but the brand again does not link to the study they’re referencing and we can’t locate it, so we have no way to verify whether this information is accurate, and at what dose turmeric has this effect.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eOur Recommendation for Pain Relief\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe would recommend turmeric extract with black pepper extract (sometimes referred to by a trademarked brand name “BioPerine”) instead of Heal n Soothe for pain relief. Turmeric extract is a more potent format of turmeric than the raw turmeric powder used in Heal n Soothe, and is typically standardized for curcuminoids, which are the active chemical constituents of turmeric thought to be responsible for its analgesic properties.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eBlack pepper extract \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3918523\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eis proven\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e in medical research to improve the absorption of turmeric by up to 2,000%, which is why this ingredient is almost always included in high-quality analgesic supplements that contain turmeric.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAn extensive \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33511486\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emedical review\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e of turmeric extract for pain relief examined data from 16 clinical trials on the topic, encompassing 1,810 trial participants. The researchers found that turmeric extract supplementation significantly reduced pain and improved physical function. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe daily dose of turmeric extract cited in the review ranged from 80 mg to 2,000 mg, with the majority of trials using doses towards the higher end of that range.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eHeal n Soothe User Reviews\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eHeal n Soothe has been reviewed over 6,000 times \u003c\/span\u003e\u003ca href=\"https:\/\/www.amazon.com\/Anti-Inflammatory-Supplement-Proteolytic-Enzyme\/dp\/B00MH4H3QQ\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eon Amazon\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e. Its average rating is 4\/5 stars, but its adjusted rating \u003c\/span\u003e\u003ca href=\"https:\/\/www.fakespot.com\/product\/heal-n-soothe\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eon FakeSpot\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e is only 2.5\/5 at the time of writing this article, and its FakeSpot review grade is C. FakeSpot is an algorithm that detects potentially fraudulent Amazon reviews. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe top positive review from a verified purchaser is written by an anonymous “Amazon Customer” who claims the product relieved their knee arthritis:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e“I have used Heal and Sooth for over 2 years now and would not be without it. The arthritis in my knees has been so bad at times, I couldn't stand putting weight on it. I started off taking 3 tablets in the morning and 3 at night. I noticed an improvement by the second week. I couldn't afford to keep taking them at that price so after a month I cut back to 3 tablets each day in the morning. I found that was enough to keep the pain at bay and allow me to go about my normal activities.”\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe top negative review from a ve\u003c\/span\u003e\u003cspan style=\"font-weight: 400;\"\u003erified purchaser comes from a user named “Derek Switzer” who claims the supplement caused uncomfortable side effects:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e“Product causes extreme acid reflux issues. They are aware of this issue bc they tell you to drink lots of water with the supplement AND afterwards yet it doesn’t help. They recommend you mix with with applesauce if you have trouble with it causing reflux issues. Well, when you bust them open and sprinkle on applesauce, the applesauce becomes so spicy that you can hardly eat it.”\u003c\/b\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eHeal n Soothe Price\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAt the time of writing this article, Heal n Soothe is significantly cheaper on Amazon than on the manufacturer website. Thus, even though we don’t recommend this supplement, we would recommend that consumers set on purchasing it do so through Amazon. It can often be easier to request refunds from Amazon than from manufacturers as well.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/healnsoothe.com\/products\/141\/sp-hns\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eOfficial website\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e: $69.95\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/www.amazon.com\/Anti-Inflammatory-Supplement-Proteolytic-Enzyme\/dp\/B00MH4H3QQ\/ref=cm_cr_arp_d_product_top?ie=UTF8\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eAmazon\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e: $49\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eHeal n Soothe Pros and Cons\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eHere’s our take on the pros and cons of this product:\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003ePros:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eNo harmful ingredients\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eSome ingredients may be effective\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eCons:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eMany ingredients appear underdosed\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eBrand makes uncited health claims\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eRelatively expensive on manufacturer website\u003c\/span\u003e\u003c\/li\u003e\n\u003cli style=\"font-weight: 400;\"\u003e\u003cspan style=\"font-weight: 400;\"\u003ePoor FakeSpot review grade\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eConclusion\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe do not recommend Heal n Soothe as we do not believe it’s likely to be effective for pain relief based on a review of medical literature. The product may be somewhat effective, and we find it unlikely to cause harm because it contains no questionable or harmful ingredients or additives, but we believe that there are significantly better options on the market.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIn our opinion, many of the ingredients in Heal n Soothe are underdosed. We believe that turmeric extract with black pepper extract would be a more effective supplement for pain relief.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eHeal n Soothe’s website has a questionable research study section that fails to link out to the research studies they reference, and we consider the brand to be relatively low-quality overall.\u003c\/span\u003e\u003c\/p\u003e","blog_id":49281925193,"author":"Calloway Cook","user_id":26601750601,"published_at":"2022-08-06T18:17:21-04:00","updated_at":"2022-08-06T18:17:21-04:00","summary_html":"We review every active ingredient in pain relief supplement Heal n Soothe based on published medical studies to determine if it's likely to be safe and effective for reducing pain. We explain why we consider the brand's \"Research Section\" to be questionable, and highlight real user reviews of the supplement.","template_suffix":"","handle":"heal-n-soothe-review","tags":"_related:pain"}

Heal n Soothe Review: Can Enzymes Reduce Pain?

Heal n Soothe Review: Can Enzymes Reduce Pain?


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Read our Editorial Guidelines to learn more about what makes our site the premier resource for online health information.
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Read our Editorial Guidelines to learn more about what makes our site the premier resource for online health information.


Read our Editorial Guidelines to learn more about what makes our site the premier resource for online health information.

Heal n Soothe, alternatively referred to as Heal-n-Soothe, is an anti-inflammatory dietary supplement. It’s manufactured by a company called Livingwell Nutraceuticals. The brand claims that it can reduce joint pain with its blend of proteolytic enzymes and botanical ingredients.

In this article we’ll review every active ingredient in Heal n Soothe based on published medical research to determine if we believe it’s likely to be effective, or if it’s another dietary supplement that makes bold claims but comes up short.

Systemic Enzyme Blend Review

Heal n Soothe Systemic Enzyme Blend

The first section of Heal n Soothe’s ingredients consists of a “Systemic Enzyme Blend” with a total dosage of 750 milligrams (mg). 

This blend contains three different types of protease, which is a digestive enzyme that breaks down protein: Protease AM, Protease 6.0 and Alkaline Protease. We cannot find any information on Heal n Soothe’s website explaining why they use three different types of this enzyme, or what the relative benefits are.

We can’t locate any research cited on Heal n Soothe’s website suggesting or proving that protease supplementation reduces pain. In fact, we identified a medical review published in the Seminars in Thrombosis and Hemostasis journal with the following title: “Protease-activated receptors: how proteases signal to cells to cause inflammation and pain.”

The review clarifies that some proteases that are produced by the body contribute to pain and inflammation, not necessarily exogenously supplemented proteases like those in Heal n Soothe, but we still consider this to be a bad sign.

We cannot find a single medical study suggesting that supplemental protease reduces pain.

Bromelain is another active ingredient in the Systemic Enzyme Blend. This is an enzyme that’s typically extracted from pineapple. The listed dose in Heal n Soothe is 6,000,000 Food Chemical Codex Papain Units (FCCPU). It’s unclear how many mg this equates to, and Heal n Soothe does not appear to provide this information on their website.

A clinical trial published in 2002 found that supplemental bromelain reduced knee pain in patients at doses of 200 mg and 400 mg. A medical review found that bromelain reduces the expression of several inflammatory markers.

We will consider this a potentially effective ingredient, though we can’t say it’s conclusively effective without understanding the dosage in mg units.

The final active ingredient in this blend is papain, which is an enzyme sourced from papaya. This ingredient was found in a medical trial to significantly reduce lower back pain in arthritis patients in combination with bromelain. This trial described dosage in mg, while the dosage in Heal n Soothe is described again in FCCPU. We would urge Livingwell Nutraceuticals to change their listing of dosage to mg, which seems to be the medical standard, and which would make it easier for researchers and consumers to evaluate the efficacy of their supplement.

We will consider papain potentially effective, depending on dosage.

Overall we consider this blend to be decently formulated for analgesic (pain-relieving) function. Two of the three ingredients appear to have medical backing, though we cannot evaluate if these ingredients are effectively dosed due to the way Heal n Soothe reports dosage.

Botanical Active Ingredient Review

Heal n Soothe botanical active ingredients list

Outside of the Systemic Enzyme Blend, Heal n Soothe contains a number of active ingredients.

The highest-dose active ingredient in this section is Boswellia serrata extract, at a dosage of 150 mg. This appears to be an effective dose for pain management. A medical review of this herbal compound, which analyzed data from 7 individual medical trials on the topic, reported the effective therapeutic dosing range of boswellia serrata extract to be 100 - 250 mg.

Citrus bioflavonoid complex is the next-listed ingredient at a dosage of 90 mg. While these compounds have documented analgesic effects in medical research, we cannot find any studies proving they’re effective at such a low dose. The minimum dose from the research trials in the above-linked medical review was 150 mg/day.

Ginger root extract is included at 90 mg. We consider this an ineffective and underdosed amount. One of the medical studies linked to on the Heal n Soothe site states the following: “Also, the daily dosage varied from 600 to 2500 mg. Similarly, in a recent systematic review on the use of ginger in CINV, typical dosing regimens were 1–2 g of ginger.” The other study the brand linked to used a 255 mg ginger extract dosage.

We find it to be somewhat ironic that the brand’s own citations prove the amount of ginger they used is underdosed.

Yucca is proven to be an effective anti-inflammatory compound. We cannot find dosing recommendations so we will consider this a potentially effective ingredient inclusion.

Turmeric is another active ingredient in this formulation at a dose of 60 mg. This is a very low dose of turmeric, and Heal n Soothe uses raw turmeric (like what you’d find in a grocery store spice aisle) rather than turmeric extract, which is what most medical studies on the compound use because it’s more potent. 

As we outlined in our review of Instaflex, which is another anti-inflammatory dietary supplement, the minimum effective therapeutic dose of turmeric extract is 1,000 mg, which is over 10x the dose of the raw, un-extracted version used in Heal n Soothe. Thus we will consider this an ineffective inclusion.

Alpha-lipoic acid also appears to be underdosed in Heal n Soothe at only 50 mg. The minimum effective dose we could find of this compound is 400 mg from a 2021 research trial.

Another ingredient we would consider underdosed is Devil’s Claw root extract, which is included at a dose of 30 mg in the supplement. A medical review of this herb found that it was effective for pain reduction, but the average dose used in the analyzed trials was over 1,000 mg, which is over 30x more than that in Heal n Soothe.

The final active ingredient is rutin, and we cannot identify any medical evidence that 30 mg of rutin is effective for reducing pain.

It’s worth noting that Heal n Soothe contains inactive ingredients which are non-toxic and safe, which is a good sign because some supplements contain additives like added sugar and artificial dyes which may be harmful to health.

Overall we consider this to be a relatively poor formulation and we would not recommend it. While most of the ingredients do have some research backing, we believe that most of the botanical ingredients in this supplement are underdosed (sometimes significantly). The only ingredient in the botanical ingredients section that we identified as effectively dosed is boswellia serrata extract.

Questionable Research Studies Section

Heal n Soothe research studies section of their website

Heal n Soothe’s website contains a Research Studies section which we find to be effectively pointless.

This section states that bromelain has been found to be effective for pain at a 400 mg dosage, but as we described in the previous section, the brand does not list dosage in terms of mg, so this information is useless to consumers. Further, the brand doesn’t link to the study in question so consumers have no ability to verify whether this health claim is true.

The second health claim is that turmeric can inhibit formation of an enzyme that causes inflammation and pain, but the brand again does not link to the study they’re referencing and we can’t locate it, so we have no way to verify whether this information is accurate, and at what dose turmeric has this effect.

Our Recommendation for Pain Relief

We would recommend turmeric extract with black pepper extract (sometimes referred to by a trademarked brand name “BioPerine”) instead of Heal n Soothe for pain relief. Turmeric extract is a more potent format of turmeric than the raw turmeric powder used in Heal n Soothe, and is typically standardized for curcuminoids, which are the active chemical constituents of turmeric thought to be responsible for its analgesic properties.

Black pepper extract is proven in medical research to improve the absorption of turmeric by up to 2,000%, which is why this ingredient is almost always included in high-quality analgesic supplements that contain turmeric.

An extensive medical review of turmeric extract for pain relief examined data from 16 clinical trials on the topic, encompassing 1,810 trial participants. The researchers found that turmeric extract supplementation significantly reduced pain and improved physical function. 

The daily dose of turmeric extract cited in the review ranged from 80 mg to 2,000 mg, with the majority of trials using doses towards the higher end of that range.

Heal n Soothe User Reviews

Heal n Soothe has been reviewed over 6,000 times on Amazon. Its average rating is 4/5 stars, but its adjusted rating on FakeSpot is only 2.5/5 at the time of writing this article, and its FakeSpot review grade is C. FakeSpot is an algorithm that detects potentially fraudulent Amazon reviews. 

The top positive review from a verified purchaser is written by an anonymous “Amazon Customer” who claims the product relieved their knee arthritis:

“I have used Heal and Sooth for over 2 years now and would not be without it. The arthritis in my knees has been so bad at times, I couldn't stand putting weight on it. I started off taking 3 tablets in the morning and 3 at night. I noticed an improvement by the second week. I couldn't afford to keep taking them at that price so after a month I cut back to 3 tablets each day in the morning. I found that was enough to keep the pain at bay and allow me to go about my normal activities.”

The top negative review from a verified purchaser comes from a user named “Derek Switzer” who claims the supplement caused uncomfortable side effects:

“Product causes extreme acid reflux issues. They are aware of this issue bc they tell you to drink lots of water with the supplement AND afterwards yet it doesn’t help. They recommend you mix with with applesauce if you have trouble with it causing reflux issues. Well, when you bust them open and sprinkle on applesauce, the applesauce becomes so spicy that you can hardly eat it.”

Heal n Soothe Price

At the time of writing this article, Heal n Soothe is significantly cheaper on Amazon than on the manufacturer website. Thus, even though we don’t recommend this supplement, we would recommend that consumers set on purchasing it do so through Amazon. It can often be easier to request refunds from Amazon than from manufacturers as well.

Official website: $69.95

Amazon: $49

Heal n Soothe Pros and Cons

Here’s our take on the pros and cons of this product:

Pros:

  • No harmful ingredients
  • Some ingredients may be effective

Cons:

  • Many ingredients appear underdosed
  • Brand makes uncited health claims
  • Relatively expensive on manufacturer website
  • Poor FakeSpot review grade
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Conclusion

We do not recommend Heal n Soothe as we do not believe it’s likely to be effective for pain relief based on a review of medical literature. The product may be somewhat effective, and we find it unlikely to cause harm because it contains no questionable or harmful ingredients or additives, but we believe that there are significantly better options on the market.

In our opinion, many of the ingredients in Heal n Soothe are underdosed. We believe that turmeric extract with black pepper extract would be a more effective supplement for pain relief.

Heal n Soothe’s website has a questionable research study section that fails to link out to the research studies they reference, and we consider the brand to be relatively low-quality overall.





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