Arthrozene Review: Is Natural Pain Relief Possible?

Arthrozene Review: Is Natural Pain Relief Possible?

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​​Disclaimer: None of the information in this article constitutes medical advice, and is just the opinion of the writer(s). We recommend that patients follow their doctor’s guidance in regard to pain relief.

Arthrozene is a pain relief supplement manufactured by a company called Fisico Inc. that claims to "soothe discomfort," "ease stiffness" and improve flexibility and mobility. The brand claims that these results can be seen in as little as five days.

But can an over-the-counter (OTC) supplement really provide dramatic pain relief or are these just marketing claims? Are the ingredients in Arthrozene shown in research studies to work? Does the supplement contain any questionable additive ingredients? And can it cause side effects?

In this article we’ll answer all of these questions and more, as we analyze the ingredients in Arthrozene based on clinical studies, to give our take on whether or not the supplement is likely to relieve pain.

We'll also discuss the potential for side effects and feature unsponsored customer reviews.

Ingredient Analysis

Arthrozene ingredients

The ingredients in Arthrozene are shown above.

Arthrozene only has three active ingredients: Boswellia serrata extract, chicken comb extract and collagen.

Boswellia serrata extract is an herbal extract sourced from a tree native to the Arabian peninsula. We consider it effective for pain relief.

A clinical trial on this ingredient at same dosage as in Arthrozene found that it was significantly more effective than placebo at reducing pain and improving joint function.

A medical review published in the BMC Complementary Medicine and Therapies journal analyzed data from seven clinical trials on Boswellia and pain, and concluded the following:

"Based on current evidence, Boswellia and its extract may be an effective and safe treatment option for patient with [osteoarthritis]".

Natural chicken comb extract is the second ingredient in this supplement, and a patented extract called “Mobilee” is used. This extract has been shown in clinical studies to relieve pain.

A 2014 clinical trial on healthy volunteers with joint irritation compared Mobilee with a placebo for pain management. The group taking Mobilee experienced significant pain reduction. The dosage used in the study is the exact same as that in Arthrozene.

An animal study on chicken comb extract found similarly impressive results. Dogs with osteoarthritis who consumed this ingredient experienced “improvements in osteoarthritis biomarkers.”

Type II Native Collagen is included at a 40 milligram (mg) dose.

As we documented in our Instaflex reviews article, collagen is often used at much higher daily doses than 40 mg.

However, type II collagen has been clinically shown to relieve pain even at as low a dose as exists in Arthrozene.

Researchers from the above-linked medical review suggested that type II collagen appears to have an anti-inflammatory effect in cartilage.

The inactive ingredients in Arthrozene should be safe and non-toxic.

Overall, we consider Arthrozene likely to provide pain relief, because all three of its active ingredients appear to be effectively dosed for supporting that outcome.

This is one of the best-formulated pain relief supplements that we've reviewed to date on Illuminate Health, from both an efficacy and safety perspective.

Does Arthrozene Cause Side Effects?

Arthrozene doesn't appear to have been tested in any clinical trials, which makes it more challenging to determine whether or not the supplement will cause side effects.

However, we can make an educated guess based on its ingredients.

We do not consider Arthrozene likely to cause side effects in otherwise healthy individuals. Its ingredients (both active and inactive) seem to have favorable safety profiles based on existing clinical studies.

There is no mention of side effects on the FAQs page of Arthrozene's website at the time of updating this article.

Real People Try Arthrozene

A YouTube creator named "Supplement Critique" reviewed arthrozene and shares whether or not the supplement helped to reduce joint pain:

Arthrozene currently has an average review rating of 3.6 out of 5 stars on Facebook.

Our Clean Joint Health Picks

There are natural compounds which have been shown in clinical studies to support optimal joint health and relieve pain.

Momentous Collagen Powder is our top collagen supplement pick.

Collagen is the core structural protein in joints, and has been clinically shown to reduce arthritic pain. Bulletproof's supplement contains collagen sourced from grass-fed animals.

Cornbread CBD Lotion is our top CBD lotion pick.

Cannabidiol (CBD) is clinically shown to be effectively absorbed through the skin, and CBD caused "significant improvements in pain" when applied topically in a 2020 clinical trial.

Cornbread's lotion also contains menthol, which was shown in a 2022 clinical trial to reduce pain scores.

Illuminate Labs Ceylon Cinnamon Extract is our standardized cinnamon supplement, which is third-party tested for purity and potency and costs only $15 at a subscription price.

Cinnamon was shown to reduce inflammatory markers in a 2020 clinical trialThe study authors concluded that “Cinnamon could be regarded as a safe supplement to relieve pain.”

All of the products recommended in this section are entirely free of ingredients that we consider to be unhealthy.

Can Stretching Help Relieve Arthritic Pain?

A YouTube video from the "Versus Arthritis" channel includes back and neck stretches that the creator suggests may help to relieve arthritic pain:

Pros and Cons of Arthrozene

Here's our take on the pros and cons of Arthrozene:


  • Research-backed active ingredients
  • Effectively dosed active ingredients
  • No questionable additive ingredients
  • Better-than-average formulation
  • Unlikely to cause side effects
  • Should support pain relief


  • Relatively expensive
  • Challenging to find real user reviews online
  • Doesn't appear to be clinically tested
Stay up-to-date on our research reviews


Arthrozene is better-formulated than most of the pain relief supplements we've reviewed to date on Illuminate Health.

All three of the active ingredients in this formulation have significant clinical backing, and we consider all three to be effectively dosed.

There are no active or inactive ingredients in Arthrozene that we consider unsafe or likely to cause side effects, and there are currently no side effect warnings on the brand's website that we can identify.

The brand's website appears to be the only official distributor of this supplement.

In this article, we featured a free stretching video for arthritis that may be useful for readers seeking natural solutions.