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{"id":556154421321,"title":"Bio X4 Review: Probiotics for Weight Loss?","created_at":"2022-01-30T00:01:37-05:00","body_html":"\u003cscript type=\"application\/ld+json\"\u003e\/\/ \u003c![CDATA[\n{\n \"@context\": \"https:\/\/schema.org\",\n \"@type\": \"Article\",\n \"headline\": \"Bio X4 Review: Probiotics for Weight Loss?\",\n \"keywords\": \"bio x4, bio x4 review, bio x4 reviews, nucific bio x4, nucific bio x4 reviews, bio x4 scam\",\n \"description\": \"Our MD and research team review the ingredients in Bio X4 based on medical research to determine whether it’s likely to be safe and effective. We explain some dosage issues and highlight an alternative supplement with more medical backing for weight loss.\",\n \"url\": \"https:\/\/illuminatelabs.org\/blogs\/health\/bio-x4-review\",\n\"author\": {\n \"@type\": \"Person\",\n \"name\": \"Taylor Graber MD\",\n \"url\": \"https:\/\/illuminatelabs.org\/pages\/taylor-graber\",\n \"sameAs\": \"https:\/\/www.linkedin.com\/in\/taylor-j-graber-md-81351642\/\",\n \"jobTitle\": \"Content Partner\",\n \"knowsAbout\": \"medicine, health, anesthesiology, iv therapy, science, drugs, pharmaceutical, medical research, scientific research, medical journals, entrepreneurship, healthcare, orthopedic surgery, biomedical engineering\",\n \"alumniOf\": {\n \"@type\": \"EducationalOrganization\",\n \"name\": [\n \"University of California San Diego\",\n \"Arizona University\",\n \"University of Arizona College of Medicine\"\n ]\n },\n \"memberOf\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n }\n},\n\"contributor\": {\n \"@type\": \"Person\",\n \"name\": \"Calloway Cook\",\n \"url\": \"https:\/\/illuminatelabs.org\/pages\/calloway-cook\",\n \"sameAs\": \"https:\/\/www.linkedin.com\/in\/calloway-cook\/\",\n \"jobTitle\": \"President\",\n \"knowsAbout\": \"entrepreneurship, dietary supplements, herbal supplements, eCommerce, medical research\",\n \"alumniOf\": {\n \"@type\": \"EducationalOrganization\",\n \"name\": \"S.I. Newhouse School of Public Communications at Syracuse University\"\n },\n \"memberOf\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n }\n},\n\"editor\": {\n \"@type\": \"Person\",\n \"name\": \"DJ Mazzoni\",\n \"honorificSuffix\": [\n \"M.S.\",\n \"R.D.\",\n \"C.D.N.\",\n \"C.S.C.S.\"\n ],\n \"url\": \"https:\/\/illuminatelabs.org\/pages\/dj-mazzoni\",\n \"sameAs\": \"https:\/\/www.linkedin.com\/in\/dj-mazzoni-rd-cdn-cscs-00a33038\/\",\n \"jobTitle\": \"Medical Reviewer\",\n \"knowsAbout\": \"exercise, drugs, pharmaceutical, health, workout, strength and conditioning, nutrition, dietetics, medicine, medical research, scientific research, scientific method, healthcare, patient care, wellness\",\n \"alumniOf\": {\n \"@type\": \"EducationalOrganization\",\n \"name\": [\n \"State University of New York College Oswego\",\n \"D’Youville College\"\n ]\n },\n \"memberOf\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n }\n},\n\"image\": {\n\"@type\": \"ImageObject\",\n\"url\": \"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Bio_X4_Thumbnail.jpg?v=1643580771\",\n\"width\": \"1010\",\n\"height\": \"1010\"\n},\n\"citation\": [\n\"https:\/\/illuminatelabs.org\/blogs\/health\/floraspring-review\", \n\"https:\/\/illuminatelabs.org\/blogs\/health\/provitalize-review\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22634320\/\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25062610\/\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26093535\/\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19597519\/\",\n\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8406948\/\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23642949\/\",\n\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8579607\/\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34159755\/\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11396693\/\",\n\"https:\/\/illuminatelabs.org\/blogs\/health\/eat-healthy-dollar-tree\"\n],\n\"mentions\": [{\n \"@type\": \"Thing\",\n \"name\": \"probiotic species\"\n },\n {\n \"@type\": \"Thing\",\n \"name\": \"dietary fiber\"\n }\n],\n\"datePublished\": \"2022-01-31\",\n\"copyrightHolder\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n},\n\"publisher\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\",\n \"url\": \"https:\/\/illuminatelabs.org\/\",\n \"description\": \"Illuminate Labs is the most transparent supplement company in the U.S., and is a leading publisher of research-based health information.\",\n \"knowsAbout\": \"supplements, science, nutrition, exercise, health, medication, pharmaceutical, wellness, diet, weight loss, medical research\",\n \"publishingPrinciples\": \"https:\/\/illuminatelabs.org\/pages\/editorial-guidelines\",\n \"logo\": {\n \"@type\": \"ImageObject\",\n \"url\": \"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Illuminate_Labs_Logo.png?v=1641249064\", \n \"width\": 150,\n \"height\": 150\n},\n \"foundingDate\": \"2019-01-30\",\n \"Address\": {\n \"@type\": \"PostalAddress\",\n \"streetAddress\": \"50 Union Street, Unit 9\",\n \"addressLocality\": \"Northampton\",\n \"addressRegion\": \"Massachusetts\",\n \"postalCode\": \"01060\",\n \"addressCountry\": \"US\"\n},\n \"sameAs\": [\n \"https:\/\/www.instagram.com\/illuminatelabs\",\n \"https:\/\/twitter.com\/illuminatelabs\",\n \"https:\/\/www.linkedin.com\/company\/illuminate-labs-supplements\",\n \"https:\/\/www.youtube.com\/channel\/UCpgSJAsIPb-fZ25djtTxBEA\"\n ]\n }\n}\n\/\/ ]]\u003e\u003c\/script\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Bio_X4_Review_Article_Header_Image_Optimized.png?v=1643520301\" alt=\"\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan class=\"dc\"\u003eB\u003c\/span\u003eio X4 is a probiotic supplement manufactured by a brand called Nucific which claims it supports weight loss. We’ve seen very poor results in our previous reviews of probiotic weight loss supplements such as \u003c\/span\u003e\u003ca href=\"https:\/\/illuminatelabs.org\/blogs\/health\/floraspring-review\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eFloraspring\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e and \u003c\/span\u003e\u003ca href=\"https:\/\/illuminatelabs.org\/blogs\/health\/provitalize-review\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eProvitalize\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e, so we’re curious to explore whether Bio X4 is backed by good science.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIn this article we’ll review the ingredients in Bio X4 based on medical research to determine whether it’s likely to be safe and effective. The supplement is relatively expensive at $99 per bottle, so for that price consumers should expect a premium, potent formulation.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eIngredient Review - Probiotic Blend\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Bio_X4_Probiotic_Blend_Optimized.png?v=1643580470\" alt=\"Bio X4 Probiotic Blend ingredients\" style=\"display: block; margin-left: auto; margin-right: auto;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eBio X4’s probiotic blend contains 4 billion colony-forming units (CFU), which is the metric for probiotic dose.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe brand only lists the species and genus of probiotic, and not the strain, which is a sign of a poorly-formulated product.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eProbiotics have a genus (\u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eLactobacillus\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e), a species (\u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003erhamnosus\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e) and a strain (\u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eGG\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e). Different strains have different effects, so it’s important to accurately list this information and not only list the generic species.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eNucific also only lists the total dose of their probiotic blend rather than the dose of each individual ingredient.  \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOne of the probiotic species included (\u003c\/span\u003e\u003cb\u003e\u003ci\u003eL. acidophilus\u003c\/i\u003e\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e) was actually found to increase weight in both human and animal studies, based on a \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22634320\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emedical review\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e, so we find it strange that Nucific included it in a weight loss supplement.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWithout the strain listed, it’s challenging to evaluate the other ingredients for efficacy. One \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25062610\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emedical study\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e found that \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eB. animalis\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e subspecies \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003elactis 420\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e prevented obesity in animals, but that doesn’t necessarily mean that the generic \u003c\/span\u003e\u003cb\u003e\u003ci\u003eB. animalis\u003c\/i\u003e\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e included in Bio X4 will.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOverall the species and dose of probiotic used in this supplement seem safe. They are all well-studied. We just don’t believe there’s any proof that this blend of probiotic species is effective for any health claim, nor does the company provide any data suggesting so, so we’ll assume this blend is ineffective for weight management.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eIngredient Review - Digestive Enzyme Blend\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Bio_X4_Digestive_Enzyme_Blend_Optimized.png?v=1643580496\" alt=\"Bio X4 Digestive Enzyme blend ingredients\" style=\"display: block; margin-left: auto; margin-right: auto;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eDigestive enzymes are produced naturally by the body and we haven’t seen any evidence that healthy adults benefit from supplementing them. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThere is medical research suggesting that specific disease states, such as IBS, may benefit from digestive enzyme supplementation, but patients with chronic conditions would be taking specific medical treatments rather than this product, so we don’t really see the purpose of including this category in a generic probiotic supplement.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eIngredient Review - Weight Management Blend\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Bio_X4_Weight_Management_Blend_Optimized.png?v=1643580537\" alt=\"Bio X4 Weight Management Blend ingredients\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThere’s only one ingredient in Bio X4’s “weight management blend”, so it’s not much of a “blend”, but in any case the ingredient is \u003c\/span\u003e\u003cb\u003eGreen Tea Extract\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e standardized to 50% EGCG.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOne \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26093535\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eclinical trial\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e found that green tea extract significantly reduced weight, but the dosage was 856.8 milligrams (mg) or nearly 10x the dose in Bio X4.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eA \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19597519\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003ethorough medical review\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e of green tea extract and weight loss was published in the International Journal of Obesity in 2009. The researchers examined results from 15 individual trials on the topic, and found that green tea increased weight loss on average.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe lowest dose used in any of the trials was 270 mg\/day, which is significantly higher than the 100 mg of green tea extract in Bio X4.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAnother \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8406948\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emedical review\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e reported that for a supplement containing green tea extract to be approved for weight management claims by Health Canada, it must have between 126 and 300 mg EGCG. Bio X4’s green tea extract contains 50 mg EGCG, or less than half the required dose.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eBased on the available research, and considering that Nucific doesn’t publish any of their own, we conclude that the weight management blend is underdosed and ineffective. We wouldn’t recommend green tea extract for long-term use in any case because there are so many safer alternatives for weight loss. There are toxicity concerns with high dose green tea extract used over long periods of time.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eIngredient Review - Craving Control Blend\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Bio_X4_Craving_Control_Blend_Optimized.png?v=1643580560\" alt=\"Bio X4 Craving Control blend ingredients\" style=\"display: block; margin-left: auto; margin-right: auto;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eBio X4’s Supplement Facts panel finishes with another single-ingredient “blend”, which is something we’d not seen prior to reviewing this product.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe ingredient in this blend is a patented plant extract called \u003c\/span\u003e\u003cb\u003eSlimaluma\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOne \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23642949\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emedical study\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e found that this plant extract was effective for reducing weight, but the daily dosage was 1 gram (g), or over 5 times the dose in Bio X4.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eA \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8579607\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emore recent medical review\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e analyzed much of the available research on the plant extract in Slimaluma, and found that when the studies were properly controlled with a placebo, there was no statistically significant effect of supplementation on weight loss.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eAll of the clinical trials analyzed by the study authors in the second-linked review had doses significantly higher than that in Bio X4.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe conclude that the Craving Control blend is another ineffective and underdosed ingredient blend.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eBetter Alternative\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eUnfortunately there isn’t much medical research proving that dietary supplements are effective for weight loss. In fact, a \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34159755\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003e2021 medical review\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e published in the Obesity journal analyzed a variety of different weight loss supplements across 315 clinical trials and found them all to be ineffective on average.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eHowever there is one food supplement that is proven to aid weight loss efforts in medical research, and that’s dietary fiber. We have discussed this at length in other weight loss supplement reviews, but medical research \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11396693\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003ehas shown\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e that increased dietary fiber conclusively leads to improved weight loss outcomes.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe above-linked study details that an additional 14 g\/day of fiber intake is associated with a decreased calorie intake of 10%, and additional weight loss of 3.8 kilograms (equivalent to 8.38 pounds) over 3.8 months.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe cheapest way to increase dietary fiber intake is to simply eat high-fiber foods, most of which are healthy because they’re necessarily whole foods.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eBeans are incredibly high in fiber and nutrients, and when purchased dry are one of the cheapest foods available, as we detailed in our article proving that it’s possible to eat healthy from the \u003c\/span\u003e\u003ca href=\"https:\/\/illuminatelabs.org\/blogs\/health\/eat-healthy-dollar-tree\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eDollar Tree\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eFiber supplements are also available for consumers who don’t like fibrous foods. Look for a powdered supplement without added sugar or sweeteners. Psyllium husk powder is a fiber supplement that’s often sold free of additives.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eConclusion\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe don’t recommend Bio X4 and find it to be very poorly formulated especially considering the price. For around $100 a consumer should expect a supplement with every ingredient backed by research and at a potent dose, but Bio X4 provides very few effectively dosed ingredients that match their health claims.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe company publishes no research suggesting their products are effective, and shares no test results proving their products are safe and\/or accurately labeled.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe don’t believe this supplement is likely to be actively harmful; just that it’s a total waste of money for relatively healthy adults looking to lose weight.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIncreasing dietary fiber intake through consumption of whole foods like beans or supplements like psyllium husk powder is a cheaper, safer and much more effective weight loss strategy in our opinion than taking Bio X4.\u003c\/span\u003e\u003c\/p\u003e","blog_id":49281925193,"author":"Calloway Cook","user_id":26601750601,"published_at":"2022-01-31T18:00:00-05:00","updated_at":"2022-01-31T18:03:06-05:00","summary_html":"\u003cmeta charset=\"utf-8\"\u003e\n\u003cdiv class=\"Polaris-Card_yis1o\"\u003e\n\u003cdiv class=\"Polaris-Card__Section_1b1h1\"\u003e\n\u003cdiv\u003e\n\u003cp class=\"Sd8DF\"\u003eWe review the ingredients in probiotic weight loss supplement Bio X4 based on medical research to determine whether it’s likely to be safe and effective. We explain some dosage issues and highlight an alternative supplement with more medical backing for weight loss.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"Polaris-Card_yis1o\"\u003e\n\u003cdiv class=\"Polaris-Card__Header_z4uwg\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e","template_suffix":"","handle":"bio-x4-review","tags":"_related:probiotics, _related:weight-loss"}

Bio X4 Review: Probiotics for Weight Loss?

Bio X4 Review: Probiotics for Weight Loss?


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Read our Editorial Guidelines to learn more about what makes our site the premier resource for online health information.
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Read our Editorial Guidelines to learn more about what makes our site the premier resource for online health information.


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Bio X4 is a probiotic supplement manufactured by a brand called Nucific which claims it supports weight loss. We’ve seen very poor results in our previous reviews of probiotic weight loss supplements such as Floraspring and Provitalize, so we’re curious to explore whether Bio X4 is backed by good science.

In this article we’ll review the ingredients in Bio X4 based on medical research to determine whether it’s likely to be safe and effective. The supplement is relatively expensive at $99 per bottle, so for that price consumers should expect a premium, potent formulation.

Ingredient Review - Probiotic Blend

Bio X4 Probiotic Blend ingredients

Bio X4’s probiotic blend contains 4 billion colony-forming units (CFU), which is the metric for probiotic dose.

The brand only lists the species and genus of probiotic, and not the strain, which is a sign of a poorly-formulated product.

Probiotics have a genus (Lactobacillus), a species (rhamnosus) and a strain (GG). Different strains have different effects, so it’s important to accurately list this information and not only list the generic species.

Nucific also only lists the total dose of their probiotic blend rather than the dose of each individual ingredient.  

One of the probiotic species included (L. acidophilus) was actually found to increase weight in both human and animal studies, based on a medical review, so we find it strange that Nucific included it in a weight loss supplement.

Without the strain listed, it’s challenging to evaluate the other ingredients for efficacy. One medical study found that B. animalis subspecies lactis 420 prevented obesity in animals, but that doesn’t necessarily mean that the generic B. animalis included in Bio X4 will.

Overall the species and dose of probiotic used in this supplement seem safe. They are all well-studied. We just don’t believe there’s any proof that this blend of probiotic species is effective for any health claim, nor does the company provide any data suggesting so, so we’ll assume this blend is ineffective for weight management.

Ingredient Review - Digestive Enzyme Blend

Bio X4 Digestive Enzyme blend ingredients

Digestive enzymes are produced naturally by the body and we haven’t seen any evidence that healthy adults benefit from supplementing them. 

There is medical research suggesting that specific disease states, such as IBS, may benefit from digestive enzyme supplementation, but patients with chronic conditions would be taking specific medical treatments rather than this product, so we don’t really see the purpose of including this category in a generic probiotic supplement.

Ingredient Review - Weight Management Blend

Bio X4 Weight Management Blend ingredients

There’s only one ingredient in Bio X4’s “weight management blend”, so it’s not much of a “blend”, but in any case the ingredient is Green Tea Extract standardized to 50% EGCG.

One clinical trial found that green tea extract significantly reduced weight, but the dosage was 856.8 milligrams (mg) or nearly 10x the dose in Bio X4.

A thorough medical review of green tea extract and weight loss was published in the International Journal of Obesity in 2009. The researchers examined results from 15 individual trials on the topic, and found that green tea increased weight loss on average.

The lowest dose used in any of the trials was 270 mg/day, which is significantly higher than the 100 mg of green tea extract in Bio X4.

Another medical review reported that for a supplement containing green tea extract to be approved for weight management claims by Health Canada, it must have between 126 and 300 mg EGCG. Bio X4’s green tea extract contains 50 mg EGCG, or less than half the required dose.

Based on the available research, and considering that Nucific doesn’t publish any of their own, we conclude that the weight management blend is underdosed and ineffective. We wouldn’t recommend green tea extract for long-term use in any case because there are so many safer alternatives for weight loss. There are toxicity concerns with high dose green tea extract used over long periods of time.

Ingredient Review - Craving Control Blend

Bio X4 Craving Control blend ingredients

Bio X4’s Supplement Facts panel finishes with another single-ingredient “blend”, which is something we’d not seen prior to reviewing this product.

The ingredient in this blend is a patented plant extract called Slimaluma.

One medical study found that this plant extract was effective for reducing weight, but the daily dosage was 1 gram (g), or over 5 times the dose in Bio X4.

A more recent medical review analyzed much of the available research on the plant extract in Slimaluma, and found that when the studies were properly controlled with a placebo, there was no statistically significant effect of supplementation on weight loss.

All of the clinical trials analyzed by the study authors in the second-linked review had doses significantly higher than that in Bio X4.

We conclude that the Craving Control blend is another ineffective and underdosed ingredient blend.

Better Alternative

Unfortunately there isn’t much medical research proving that dietary supplements are effective for weight loss. In fact, a 2021 medical review published in the Obesity journal analyzed a variety of different weight loss supplements across 315 clinical trials and found them all to be ineffective on average.

However there is one food supplement that is proven to aid weight loss efforts in medical research, and that’s dietary fiber. We have discussed this at length in other weight loss supplement reviews, but medical research has shown that increased dietary fiber conclusively leads to improved weight loss outcomes.

The above-linked study details that an additional 14 g/day of fiber intake is associated with a decreased calorie intake of 10%, and additional weight loss of 3.8 kilograms (equivalent to 8.38 pounds) over 3.8 months.

The cheapest way to increase dietary fiber intake is to simply eat high-fiber foods, most of which are healthy because they’re necessarily whole foods.

Beans are incredibly high in fiber and nutrients, and when purchased dry are one of the cheapest foods available, as we detailed in our article proving that it’s possible to eat healthy from the Dollar Tree.

Fiber supplements are also available for consumers who don’t like fibrous foods. Look for a powdered supplement without added sugar or sweeteners. Psyllium husk powder is a fiber supplement that’s often sold free of additives.

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Conclusion

We don’t recommend Bio X4 and find it to be very poorly formulated especially considering the price. For around $100 a consumer should expect a supplement with every ingredient backed by research and at a potent dose, but Bio X4 provides very few effectively dosed ingredients that match their health claims.

The company publishes no research suggesting their products are effective, and shares no test results proving their products are safe and/or accurately labeled.

We don’t believe this supplement is likely to be actively harmful; just that it’s a total waste of money for relatively healthy adults looking to lose weight.

Increasing dietary fiber intake through consumption of whole foods like beans or supplements like psyllium husk powder is a cheaper, safer and much more effective weight loss strategy in our opinion than taking Bio X4.





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