Mitopure is a novel supplement from a company called Timeline that contains a compound called Urolithin A. The brand describes this supplement as "The first clinically tested Urolithin A supplement," and claims that it "energizes cells."

But is Urolithin A shown in clinical research to have that effect? What were the results of the clinical trials on Mitopure? Does this supplement contain any unhealthy additive ingredients? And how do real Mitopure customers rate and describe the effects of the supplement?

In this article we'll answer all of these questions and more, as we analyze the ingredients in Mitopure to give our take on whether or not it's likely to be effective for improving energy levels, and whether or not it's healthy. 

We'll also analyze the clinical trials on Mitopure, and feature real customer reviews of the supplement.

Is Mitopure Proven to Work?

Timeline funded a clinical trial on Mitopure in older adults, published in the Nutrition, Obesity and Exercise journal.

Supplementation with the active ingredient in Mitopure (at twice the dose) caused a "significant improvement in muscle endurance" and decreased C-reactive protein levels (an inflammatory marker).

A 2022 clinical trial tested the exercise effects of Mitopure in middle-aged adults.

Leg strength and flexion were improved by around 15% in the group supplementing with Mitopure.

This trial showed the Urolithin A dose used in Mitopure to be effective (whereas the previous trial used double the dose).

At the time of publishing this article, there don't appear to be any other clinical trials on Mitopure with human participants published in peer-reviewed journals.

Overall, we consider Mitopure likely to be effective for improving exercise strength and endurance in middle-aged and older adults, however we have no evidence that it improves subjective energy levels.

Ingredient Analysis

The active ingredient in Mitopure is shown below:

As we established in the previous section, Urolithin A is clinically shown to have ergogenic (exercise-enhancing) effects in older adults both at a 500 milligram (mg) dose and a 1,000 mg dose.

The inactive ingredients in Mitopure are shown below:

These ingredients should be safe and non-toxic.

Overall, we consider Mitopure to be effectively dosed, and we consider it to have no unhealthy additives.

Real People Try Mitopure

A YouTube creator named Chris Michael Harris shared his thoughts on whether or not Mitopure was worth it for him:

A YouTube creator named Jared Taylor shared his experience after taking the active ingredient in Mitopure for 30 days:

Where to Get the Best Price

Mitopure is currently sold at the brand's website and at Amazon.

Here's a price breakdown for a one-time purchase at the time of publishing this article:

Amazon: $125 (free shipping, link to official Amazon listing)

Brand website: $112.50 (free shipping, requires subscription, link)

The brand's website currently offers a better price, but requires a monthly subscription, so Amazon may be a better choice for consumers who just want to try the product once.

Does Mitopure Cause Side Effects?

Mitopure appears to have a favorable side effect profile according to the clinical trials we cited previously in this article.

The first trial reported "no statistical differences in adverse events" between the group taking placebo pills and the group taking Mitopure.

In the second trial, the placebo group reported more adverse events, which suggests that Mitopure doesn't cause any significant side effects.

A medical review on Urolithin A, published in the Nutrients journal, didn't report any side effects.

Overall, we consider Mitopure unlikely to cause side effects in healthy adults.

Customers Rate Mitopure

We consider Amazon to be a better resource for honest customer reviews than a brand's website.

At the time of publishing this article, Mitopure has been reviewed over 500 times on Amazon, with an average review rating of 4 out of 5 stars.

A top positive review from a verified purchaser comes from a user named "cassiexx430" who gave the product a 5/5 rating:

"This supplement...has significantly boosted my energy levels and reduced end of day fatigue. Additionally, I noticed improvements in my skin’s hydration and resilience."

A top negative review from a verified purchaser is written by a user named "VS" who gave the product a 1/5 rating:

"I [started] with a lower dosage than the one it says, I moved up slowly to the dosage it recommends and I gave me the worst migranes of my life, neck and bottom of the head inflammation pain. I ended up at the ER with the worst migrane of my life. I took a break from it after I got out of the ER and the headaches and neck and shoulder pain went away."

Timeline Nutrition currently has a 65% recommendation rating on Facebook.

Mitopure Pros and Cons

Here are the pros and cons of Mitopure in our opinion:

Pros:

• Clinically tested
• May improve strength in older adults
• May improve endurance in older adults
• Unlikely to cause side effects
• No unhealthy additives
• Great branding
• Free shipping from brand's website
• Positive Amazon reviews

Cons:

• Mediocre Facebook reviews
• We can't find evidence of benefit in younger adults
• We can't find evidence for subjective energy improvements

Conclusion

Mitopure is a high-quality supplement brand in our view.

Its manufacturer, Timeline Nutrition, funded clinical trials published in peer-reviewed journals, which is uncommon for dietary supplements, and which is the gold standard for product research.

The trials found that Mitopure has ergogenic effects in middle-aged and older adults.

We're unable to identify any clinical trials showing that Mitopure is beneficial in individuals under the age of 40.

We do not consider Mitopure likely to cause side effects, as no greater rate of side effect reporting was seen in the Mitopure group compared to the placebo group in the trials.

The inactive ingredients in Mitopure should be safe and non-toxic, and there are no ingredients in this formulation that we consider to be dangerous or unhealthy.

At the time of publishing this article, the brand's website has the best price on Mitopure.