Scream Cream Review: Does it Improve Sex?

Scream Cream Review: Does it Improve Sex?

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Disclaimer: None of the information in this article constitutes medical advice, and is just the opinion of the writer(s). We recommend that patients follow their doctor’s guidance in regard to sexual enhancement.

Scream Cream is a female sexual enhancement product that’s used on the skin. It requires a prescription, and is sold at a variety of online retailers.

But is Scream Cream actually proven to work in medical studies, or is it a waste of money? Is it dangerous? Does it cause side effects? And how do real users rate and describe the effects?

In this article we’ll answer all of these questions and more, as we analyze the ingredients in Scream Cream based on medical studies to give our take on whether or not it’s likely to be effective.

We’ll also discuss side effects and feature unsponsored customer reviews.

Ingredient Analysis

Scream Cream ingredients

The ingredients in Scream Cream sold by CareFirst Pharmacy (which claims on their website to be a nationally accredited compounding pharmacy), are shown above.

We’ve seen different Scream Cream ingredient lists across different online retailers, which raises red flags in our opinion.

Aminophylline is the first-listed ingredient, and seems like a very strange choice for a sexual enhancement cream, as it’s a bronchodilator, meaning it prevents airway obstruction when inhaled.

We can’t find any clinical evidence that topical aminophylline improves sexual function in women, nor can we even find any clinical trials testing it for this effect.

L-arginine is an amino acid, and while a 2021 medical review concluded that this compound may be effective at increasing libido in women when administered orally, we can’t find any evidence it’s effective when administered topically, nor does the pharmacy mentioned above cite any on their product page.

Testosterone is a male sex hormone, as we documented in our Weider Prime review article.

We haven’t come across any medical studies suggesting that topical testosterone is effective or safe in women for improving sexual drive or performance.

Overall, we cannot find any evidence for any of the active ingredients in Scream Cream, and we find this to be a highly questionable formulation.

It’s also notable that Scream Cream does not appear to be clinically tested, which raises questions about long-term safety.

We do not currently recommend this product.

But how do real users rate and describe its effects? We’ll feature real customer reviews in the next section of this article.

Real People Try Scream Cream

A TikTok creator named Sue McGarvie shares her thoughts on Scream Cream:

@coffeewithsue ♬ original sound - Sue McGarvie

A TikTok creator named The Aud Compounder shares an interesting video of how Scream Cream is made in the pharmacy:

@theaudcompounder Making “Scream Cream” for women tbat need help having an orgasm. #fyp #foryoupage #fypシ #compoundingpharmacy #pharmacytechnician #pharmacytiktok #asmr #compoundingchemist #pharmacyasmr #compounding #chemistry #pharmacylife #orgasmforthewin #screamcream ♬ original sound - The Aud Compounder

Is Scream Cream Dangerous?

As stated in the ingredient analysis section, Scream Cream does not appear to be clinically tested. It’s also not currently FDA-approved, both of which may increase the potential for side effects since there is a lack of research on the safety of these ingredients combined.

The fact that Scream Cream is topical may reduce the risk of severe side effects compared to oral medication, because less of the active ingredients may be absorbed.

Testosterone may cause acne and hair loss in women, among other side effects, according to a medical review published in the Systematic Reviews journal.

It’s unclear if these effects occur during transdermal use, or only with oral testosterone.

Pentoxifylline can cause dizziness, headache, anxiety and confusion as documented in a 2014 medical review.

Overall, we’re unable to make any specific determination about the likelihood of side effects for Scream Cream, which is why it seems so risky.

We’d certainly recommend that patients speak with a doctor about using these ingredients topically and potential risks.

Our Clean Women's Libido Picks

Ristela by Bonafide is our top overall women's libido pick.

The four active ingredients in this supplement are clinically shown to improve sexual desire and satisfaction scores by over 100% after eight weeks.

Momentous Vitamin D3 is our top value women's libido pick.

Vitamin D was shown to improve sexual desire, orgasm and satisfaction in young women with low vitamin D status in a 2018 clinical trial

Momentous Zinc is our top libido pick for postmenopausal women.

A 2021 clinical trial concluded that zinc supplementation can improve sexual function in postmenopausal women.

Pros and Cons of Scream Cream

Here are the pros and cons of Scream Cream in our opinion:


  • Topical use may be safer than oral
  • Compounded by pharmacies


  • Doesn’t appear clinically tested
  • Active ingredient concentrations not published
  • No information about inactive ingredients
  • Different online pharmacies sell different formulations
  • Not FDA-approved
  • No proof of efficacy
  • No long-term proof of safety
  • We can’t identify any active ingredients we consider effective
  • Hard to find real customer reviews
Stay up-to-date on our research reviews


Scream Cream is among the worst sexual enhancement products for women that we’ve reviewed to date on Illuminate Health. 

While this product requires a prescription and is compounded by a pharmacy, which adds legitimacy, we can’t find any proof that it’s effective.

Not only do there not appear to be any clinical trials showing this specific blend of ingredients to be effective in combination, we can’t even find proof that any of these ingredients are effective in isolation.

Different online pharmacies are selling different formulations under the Scream Cream trade name, which is another red flag in our opinion.

Some of the active ingredients in Scream Cream appear to cause side effects when used topically, but it’s challenging to determine risk of side effects when the relative concentrations are not published.

Overall, we think there are much better options on the market for enhancing sex drive in women, both in regard to pharmaceutical treatments and over-the-counter (OTC) products.

We would strongly recommend that women considering this product speak with a doctor first about potential risks.