Disclaimer: None of the information in this article constitutes medical advice. All statements are merely the opinion of the writer(s). We recommend that patients follow their doctor’s guidance in regard to pain relief.
Biofreeze and Icy Hot are two of the most popular pain relieving creams on the market. Both creams claim to work fast, and it can be challenging for consumers to differentiate between the two products.
But do Biofreeze and Icy Hot both have ingredients shown in medical studies to relieve pain? Which product has the better formulation? Does either cream have unhealthy additive ingredients? And how do real users compare the effects of the two products?
In this article we’ll answer all of these questions and more, as we analyze the ingredients in Biofreeze and Icy Hot based to give our take on which product has a better formulation for pain relief, and which we would recommend.
We’ll feature real, unsponsored user comparisons between the two products and provide a cost breakdown to determine which is cheaper.
Key takeaways:
- Biofreeze has a healthier formulation in our view
- Icy Hot has a more powerful formulation
- We do not currently recommend either product from a health perspective
Ingredient Analysis – Biofreeze
The ingredients in Biofreeze Colorless Pain Relief Gel are shown below:
Menthol is the active ingredient, and is clinically shown to reduce pain when applied to the skin.
A 2022 clinical trial found that menthol significantly reduced pain scores when applied to the skin. This is a commonly-used drug ingredient, and also the active ingredient in products like Vicks VapoRub.
A clinical trial published in the Journal of Geriatric Physical Therapy reported that pain scores and the ability to complete functional tasks improved significantly in patients with arthritis after application of a menthol gel.
Aloe Barbadensis (aloe vera) is clinically shown to support wound healing.
Camphor was described in a 2021 clinical trial as having anti-inflammatory and pain-relieving effects when applied topically.
Triethanolamine is a pH balancer that was shown in animal studies to be toxic, as we documented in our review of Perbelle cosmetics.
Overall, we consider Biofreeze likely to be effective for pain relief, but we don't currently recommend it due to the inclusion of triethanolamine.
Ingredient Analysis – Icy Hot
The active ingredients in Icy Hot are shown below:
Menthol is included at the exact same concentration as in Biofreeze, and we already documented the research backing of this ingredient for pain relief in the previous section.
Menthol provides a cooling effect.
Methyl salicylate provides a warming effect, which is why the product is called “Icy Hot.”
This compound was shown in a clinical trial published in the Frontiers in Pharmacology journal to relieve pain in over 82% of patients.
A 2017 medical review described the pain relief capabilities of methyl salicylate as “well established,” but also discussed the potential for salicylate poisoning with over-application of topical pain relief products like Icy Hot.
A 1996 medical review described potential dangers from use of methyl salicylate on the skin, including anaphylactic reactions which can be fatal. The study authors concluded:
“Physicians should fully appreciate the potential dangers from topical preparations containing methyl salicylate.”
The inactive ingredients in Icy Hot are shown below:
Triethanolamine is a pH balancer that we consider potentially unhealthy, as we documented in the previous Ingredient Analysis section.
Overall, we consider Icy Hot likely to have a stronger pain-relieving effect, due to the higher concentration of menthol and the second active ingredient.
We consider Biofreeze to have a healthier formulation, since it's free of methyl salicylate.
Real People Compare the Two
A YouTube creator named “116falconer” compared the effects of Biofreeze and Icy Hot:
A YouTube creator named Izzy Kornblau who has chronic pain reviewed a large number of topical pain creams including Biofreeze:
Which Product is Cheaper?
Both Biofreeze and Icy Hot are relatively affordable, with the cream version of each product costing well under $15.
Since the products are sold at different sizes, here’s a price comparison per-ounce:
Icy Hot: $4.79 (link to official Amazon listing)
Biofreeze: $3.81 (link to official Amazon listing)
At the time of publishing this article, Biofreeze is 20% cheaper per-ounce than Icy Hot.
Our Clean Anti-Inflammatory Picks
Illuminate Labs Ceylon Cinnamon Extract is our top anti-inflammatory supplement.
Cinnamon was shown to reduce inflammatory markers in a 2020 clinical trial. The study authors concluded that “Cinnamon could be regarded as a safe supplement to relieve pain.”
Cornbread CBD Lotion is our top anti-inflammatory skin lotion.
Cannabidiol (CBD) is clinically shown to be effectively absorbed through the skin, and CBD caused "significant improvements in pain" when applied topically in a 2020 clinical trial.
Both of the products recommended in this section are free of ingredients that we consider to be unhealthy.
