{"id":556957597769,"title":"Peptiva Review: Can Probiotics Improve Sleep?","created_at":"2022-09-14T21:34:43-04:00","body_html":"\u003cscript type=\"application\/ld+json\"\u003e\/\/ \u003c![CDATA[\n{\n \"@context\": \"https:\/\/schema.org\",\n \"@type\": \"Article\",\n \"headline\": \"Peptiva Review: Can Probiotics Improve Sleep?\",\n \"keywords\": \"peptiva, peptiva review, peptiva reviews, peptiva ingredients, peptiva probiotic, peptiva sleep support, peptiva probiotics, peptiva gnc\",\n \"description\": \"Our research team reviews the ingredients in Peptiva based on medical studies to give our take on whether the supplement is likely to improve sleep quality or whether it's a waste of money. We highlight a questionable ingredient in Peptiva.\",\n \"url\": \"https:\/\/illuminatelabs.org\/blogs\/health\/peptiva-review\",\n\"author\": {\n \"@type\": \"Person\",\n \"name\": \"Calloway Cook\",\n \"url\": \"https:\/\/illuminatelabs.org\/pages\/calloway-cook\",\n \"sameAs\": \"https:\/\/www.linkedin.com\/in\/calloway-cook\/\",\n \"jobTitle\": \"President\",\n \"knowsAbout\": \"entrepreneurship, dietary supplements, herbal supplements, eCommerce, medical research\",\n \"alumniOf\": {\n \"@type\": \"EducationalOrganization\",\n \"name\": \"S.I. Newhouse School of Public Communications at Syracuse University\"\n },\n \"memberOf\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n }\n},\n\"creator\": {\n \"@type\": \"Person\",\n \"name\": \"Calloway Cook\",\n \"url\": \"https:\/\/illuminatelabs.org\/pages\/calloway-cook\",\n \"sameAs\": \"https:\/\/www.linkedin.com\/in\/calloway-cook\/\",\n \"jobTitle\": \"President\",\n \"knowsAbout\": \"entrepreneurship, dietary supplements, herbal supplements, eCommerce, medical research\",\n \"alumniOf\": {\n \"@type\": \"EducationalOrganization\",\n \"name\": \"S.I. Newhouse School of Public Communications at Syracuse University\"\n },\n \"memberOf\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n }\n},\n\"editor\": {\n \"@type\": \"Person\",\n \"name\": \"Taylor Graber\",\n \"honorificSuffix\": \"M.D.\",\n \"url\": \"https:\/\/illuminatelabs.org\/pages\/taylor-graber\",\n \"sameAs\": [\n \"https:\/\/www.linkedin.com\/in\/taylor-j-graber-md-81351642\/\",\n \"https:\/\/www.asapivs.com\/\"\n ],\n \"jobTitle\": \"Content Partner\",\n \"knowsAbout\": \"medicine, health, anesthesiology, iv therapy, science, drugs, pharmaceutical, medical research, scientific research, medical journals, entrepreneurship, healthcare, orthopedic surgery, biomedical engineering\",\n \"alumniOf\": {\n \"@type\": \"EducationalOrganization\",\n \"name\": [\n \"University of California San Diego\",\n \"Arizona University\",\n \"University of Arizona College of Medicine\"\n ]\n },\n \"memberOf\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n }\n},\n\"image\": {\n\"@type\": \"ImageObject\",\n\"url\": \"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Peptiva_Thumbnail.png?v=1663206242\",\n\"width\": \"3642\",\n\"height\": \"3642\"\n},\n\"citation\": [\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33609341\/\", \n\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7527439\/\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31383052\/\",\n\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4394901\/\",\n\"https:\/\/www.fas.usda.gov\/data\/european-union-titanium-dioxide-banned-food-additive-eu\",\n\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31714321\/\",\n\"https:\/\/www.fakespot.com\/product\/peptiva-probiotics-sleep-support\"\n],\n\"mentions\": [{\n \"@type\": \"Thing\",\n \"name\": \"GABA\"\n },\n {\n \"@type\": \"Thing\",\n \"name\": \"melatonin\"\n },\n {\n \"@type\": \"Thing\",\n \"name\": \"FakeSpot\"\n },\n {\n \"@type\": \"Thing\",\n \"name\": \"titanium dioxide\"\n }\n],\n\"datePublished\": \"2022-09-14\",\n\"copyrightHolder\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\"\n},\n\"publisher\": {\n \"@type\": \"Organization\",\n \"name\": \"Illuminate Labs\",\n \"url\": \"https:\/\/illuminatelabs.org\/\",\n \"description\": \"Illuminate Labs is the most transparent supplement company in the U.S., and is a leading publisher of research-based health information.\",\n \"knowsAbout\": \"supplements, science, nutrition, exercise, health, medication, pharmaceutical, wellness, diet, weight loss, medical research\",\n \"publishingPrinciples\": \"https:\/\/illuminatelabs.org\/pages\/editorial-guidelines\",\n \"memberOf\": [\n {\n \"@type\": \"Organization\",\n \"name\": \"U.S. Chamber of Commerce\",\n \"url\": \"https:\/\/www.uschamber.com\/\"\n },\n {\n \"@type\": \"Organization\",\n \"name\": \"Certified B Corp\",\n \"url\": \"https:\/\/www.bcorporation.net\/en-us\/\"\n },\n {\n \"@type\": \"Organization\",\n \"name\": \"Natural Products Association\",\n \"url\": \"https:\/\/www.npanational.org\/\"\n }\n ], \n \"logo\": {\n \"@type\": \"ImageObject\",\n \"url\": \"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Illuminate_Labs_Favicon_48x48_7595c3cc-e27b-47b8-a4fe-edcc7ed9b29a.png?v=1666502785\", \n \"width\": 48,\n \"height\": 48\n},\n \"foundingDate\": \"2019-01-30\",\n \"sameAs\": [\n \"https:\/\/www.instagram.com\/illuminatelabs\",\n \"https:\/\/twitter.com\/illuminatelabs\",\n \"https:\/\/www.linkedin.com\/company\/illuminate-labs-supplements\",\n \"https:\/\/www.youtube.com\/channel\/UCpgSJAsIPb-fZ25djtTxBEA\"\n ]\n }\n}\n\/\/ ]]\u003e\u003c\/script\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Peptiva_Review_Article_Header_Image_Optimized.png?v=1663205693\" alt=\"\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cspan class=\"dc\"\u003eP\u003c\/span\u003eeptiva is a dietary supplement for sleep support that’s sold exclusively at GNC. It has a unique formulation that’s primarily composed of probiotics, which isn’t something we’ve seen in any other sleep supplement that we’ve reviewed on Illuminate Health.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIn this article we’ll review every ingredient in Peptiva based on published medical research to provide our determination on whether the supplement is likely to be effective for improving sleep quality or if it’s a waste of money.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eBecause this supplement contains many active ingredients, we’ll break our ingredient analysis down into three sections: Probiotic Ingredient Review, Other Active Ingredient Review, and Inactive Ingredient Review.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eProbiotic Ingredient Review\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Peptiva_Probiotic_Ingredients.png?v=1663205961\" alt=\"Peptiva probiotic ingredients\"\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eMost of the ingredients in Peptiva are probiotics. The supplement provides a 26 billion colony-forming units (CFU) total dose.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eFour of the included probiotic strains are of the Lactobacillus species, including \u003c\/span\u003e\u003cb\u003e\u003ci\u003eLactobacillus acidophilus\u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e (ATCC SD6865)\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e and \u003c\/span\u003e\u003cb\u003e\u003ci\u003eLactobacillus acidophilus\u003c\/i\u003e\u003c\/b\u003e\u003cb\u003e (ATCC SD6866)\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e. We cannot identify any medical research suggesting that \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eLactobacillus\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e probiotics are effective for improving sleep quality.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIn fact, a \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33609341\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emedical review\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e published in the \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eAlternative Therapies in Health and Medicine\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e journal examined the effects of supplementation with \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eLactobacillus\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e probiotics on insomnia, and the study authors concluded that there were no studies that proved a benefit.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThis type of probiotic may be effective for sleep, but it doesn’t appear to have been proven so in clinical research.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe two other species of probiotics included in this formulation are \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eBifidobacterium\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e strains, and again we cannot identify any medical studies suggesting them to be effective for sleep. Peptiva cites no clinical studies on their website’s product page proving any of these ingredients effective, so we’ll consider them all likely ineffective at this point in time. \u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eOther Active Ingredient Review\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Peptiva_Other_Active_Ingredients.png?v=1663205993\" alt=\"Peptiva other active ingredients\" style=\"display: block; margin-left: auto; margin-right: auto;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003ePeptiva contains three other active ingredients: gamma-aminobutyric acid (GABA), valerian extract and melatonin. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eGABA\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e appears to be an effective ingredient for a sleep supplement. A \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7527439\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emedical review\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e published in the well-respected \u003c\/span\u003e\u003ci\u003e\u003cspan style=\"font-weight: 400;\"\u003eFrontiers in Neuroscience\u003c\/span\u003e\u003c\/i\u003e\u003cspan style=\"font-weight: 400;\"\u003e journal analyzed data from 14 clinical trials on GABA and sleep, and concluded the following: \u003c\/span\u003e\u003cb\u003e“doses ranging between 100 and 300 mg seems to be efficacious in reducing sleep latency with prolonged use of 1–4 weeks.”\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe GABA dose in Peptiva is 100 milligrams (mg) so we’ll consider this an effective ingredient and dose.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eMelatonin\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e is one of the most well studied and safe ingredients for enhancing sleep quality and reducing time-to-sleep. The 1.5 mg total dose in Peptiva is effective based on a \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31383052\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emeta-study\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e published in 2019 which documented the therapeutic dosing range as 1 mg to 6 mg.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe final active ingredient in this supplement is \u003c\/span\u003e\u003cb\u003evalerian extract\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e. This is an effective ingredient for sleep, but may be underdosed in Peptiva. A \u003c\/span\u003e\u003ca href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4394901\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003emeta-study\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e analyzed data on valerian extract and sleep from 16 clinical trials on the topic. The researchers found the supplement to be effective, but the minimum dose used in any of the trials was 225 mg daily. Peptiva contains only 50 mg.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe consider these ingredients to be more effective than the probiotics overall for sleep.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eInactive Ingredient Review\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Peptiva_Inactive_Ingredients.png?v=1663206011\" alt=\"Peptiva inactive ingredients\" style=\"display: block; margin-left: auto; margin-right: auto;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003ePeptiva is naturally colored with \u003c\/span\u003e\u003cb\u003ecarrot concentrate\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e which is a much healthier option than artificial dye.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe majority of inactive ingredients in this formulation are safe and non-toxic, however there is one ingredient we typically recommend consumers avoid.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003eTitanium dioxide\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e is used for its white color, but this ingredient \u003c\/span\u003e\u003ca href=\"https:\/\/www.fas.usda.gov\/data\/european-union-titanium-dioxide-banned-food-additive-eu\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eis banned\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e in the European Union (E.U.) for use as a food additive due to concerns over genotoxicity. This means that this additive can potentially damage DNA.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe dose of titanium dioxide in Peptiva is almost certainly very low, but it seems reasonable to avoid this ingredient entirely.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eWill Peptiva Improve Sleep?\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eOverall we do believe that Peptiva is likely to improve sleep quality due to the effectively-dosed GABA and melatonin. However, we don’t recommend the supplement overall because of the inclusion of titanium dioxide. We also consider the probiotic blend, while harmless, to be pointless for a sleep supplement.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eSleep supplements are a relatively cheap category of dietary supplements, and we believe there are options that may be just as effective for sleep, free of questionable additive ingredients, and better-priced than Peptiva. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe do consider Peptiva to be relatively well-formulated though, and consider the formulation to be superior to most dietary supplements we review on Illuminate Health.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003eOur Sleep Supplement Recommendation\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0047\/1524\/9737\/files\/Is_Melatonin_Safe_Article_Header_Image_Optimized_a726a044-cb5a-4172-b2da-604d5181efd7.png?v=1662522659\" alt=\"\" style=\"display: block; margin-left: auto; margin-right: auto;\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe recommend \u003c\/span\u003e\u003ca rel=\"sponsored\" href=\"https:\/\/bulletproof.fdf2.net\/a1XMvQ\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eBulletproof Sleep\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e to consumers seeking a sleep supplement.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eIt contains an effective dose of melatonin (3 mg), and also \u003c\/span\u003e\u003cb\u003epassionflower extract\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e which has been shown in a \u003c\/span\u003e\u003ca href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31714321\/\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eclinical trial\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e to increase total sleep time and decrease wakefulness. Most importantly, the supplement contains no questionable additive ingredients like flavoring agents.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eWe’re not suggesting that Bulletproof Sleep is more effective than Peptiva, but we believe it’s likely to be equally effective with a more favorable additive ingredient profile and a better price.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003ePeptiva currently costs $59.99 for 30 servings, which equates to a per-serving cost of $2. Bulletproof Sleep currently costs $29.95 for 30 servings, which equates to a per-serving cost of \u003c\/span\u003e\u003cb\u003e$0.99\u003c\/b\u003e\u003cspan style=\"font-weight: 400;\"\u003e, or over 50% cheaper than Peptiva.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eInterested consumers can buy Bulletproof Sleep \u003c\/span\u003e\u003ca rel=\"sponsored\" href=\"https:\/\/bulletproof.fdf2.net\/a1XMvQ\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eat this link\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cb\u003ePeptiva Real User Reviews\u003c\/b\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003ePeptiva has been reviewed over 3,000 times on Amazon, and has an average review rating of 4.1 out of 5 stars. The product only scores a “C” grade \u003c\/span\u003e\u003ca href=\"https:\/\/www.fakespot.com\/product\/peptiva-probiotics-sleep-support\"\u003e\u003cspan style=\"font-weight: 400;\"\u003eon FakeSpot\u003c\/span\u003e\u003c\/a\u003e\u003cspan style=\"font-weight: 400;\"\u003e, which is a software tool that detects potentially fraudulent Amazon reviews. The adjusted grade that FakeSpot gives Peptiva’s sleep supplement is 2 out of 5 stars.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe top positive review from a verified purchaser comes from a user named “Linda M.” who claims the supplement is effective:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e“The product does what it is advertised to do ! I was hesitant about the claims in the advertising but decided to take a chance , not much of a chance since it was free for a 15 day trial . I did not hesitate to order after the first week. You will be happy after trying!”\u003c\/b\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe top negative review from a verified purchaesr is written by a user named “vicelia k” who claims the product didn’t work for them:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cb\u003e“I started taking this product over a week ago, and since then I wake up every 3 hrs for no reason. I was under the impression that I would have a continuous improvement of sleeping, but do not!”\u003c\/b\u003e\u003c\/p\u003e\n\u003ch2 style=\"text-align: center;\"\u003e\u003cstrong\u003eConclusion\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003ePeptiva is a decently-formulated sleep supplement that we consider likely to improve sleep quality because it contains two effectively-dosed ingredients. However, we don’t recommend the supplement overall because it contains an additive ingredient we find questionable, and we consider it to be a cost-inefficient way to improve sleep.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThere exist other sleep supplements like Bulletproof Sleep on the market with a lower cost-per-serving and free of questionable additive ingredients.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: 400;\"\u003eThe majority of active ingredients in Peptiva constitute a probiotic blend, which we find to be a strange decision for a sleep supplement, given that very little clinical research exists suggesting that probiotics improve sleep quality.\u003c\/span\u003e\u003c\/p\u003e","blog_id":49281925193,"author":"Calloway Cook","user_id":26601750601,"published_at":"2022-09-14T21:47:10-04:00","updated_at":"2022-10-23T02:28:00-04:00","summary_html":"We review the ingredients in Peptiva based on medical studies to give our take on whether the supplement is likely to improve sleep quality or whether it's a waste of money. We highlight a questionable ingredient in Peptiva.","template_suffix":"","handle":"peptiva-review","tags":"_related:sleep"}

Peptiva Review: Can Probiotics Improve Sleep?

Peptiva Review: Can Probiotics Improve Sleep?


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Read our Editorial Guidelines to learn more about what makes our site the premier resource for online health information.

Peptiva is a dietary supplement for sleep support that’s sold exclusively at GNC. It has a unique formulation that’s primarily composed of probiotics, which isn’t something we’ve seen in any other sleep supplement that we’ve reviewed on Illuminate Health.

In this article we’ll review every ingredient in Peptiva based on published medical research to provide our determination on whether the supplement is likely to be effective for improving sleep quality or if it’s a waste of money.

Because this supplement contains many active ingredients, we’ll break our ingredient analysis down into three sections: Probiotic Ingredient Review, Other Active Ingredient Review, and Inactive Ingredient Review.

Probiotic Ingredient Review

Peptiva probiotic ingredients

Most of the ingredients in Peptiva are probiotics. The supplement provides a 26 billion colony-forming units (CFU) total dose.

Four of the included probiotic strains are of the Lactobacillus species, including Lactobacillus acidophilus (ATCC SD6865) and Lactobacillus acidophilus (ATCC SD6866). We cannot identify any medical research suggesting that Lactobacillus probiotics are effective for improving sleep quality.

In fact, a medical review published in the Alternative Therapies in Health and Medicine journal examined the effects of supplementation with Lactobacillus probiotics on insomnia, and the study authors concluded that there were no studies that proved a benefit.

This type of probiotic may be effective for sleep, but it doesn’t appear to have been proven so in clinical research.

The two other species of probiotics included in this formulation are Bifidobacterium strains, and again we cannot identify any medical studies suggesting them to be effective for sleep. Peptiva cites no clinical studies on their website’s product page proving any of these ingredients effective, so we’ll consider them all likely ineffective at this point in time. 

Other Active Ingredient Review

Peptiva other active ingredients

Peptiva contains three other active ingredients: gamma-aminobutyric acid (GABA), valerian extract and melatonin. 

GABA appears to be an effective ingredient for a sleep supplement. A medical review published in the well-respected Frontiers in Neuroscience journal analyzed data from 14 clinical trials on GABA and sleep, and concluded the following: “doses ranging between 100 and 300 mg seems to be efficacious in reducing sleep latency with prolonged use of 1–4 weeks.”

The GABA dose in Peptiva is 100 milligrams (mg) so we’ll consider this an effective ingredient and dose.

Melatonin is one of the most well studied and safe ingredients for enhancing sleep quality and reducing time-to-sleep. The 1.5 mg total dose in Peptiva is effective based on a meta-study published in 2019 which documented the therapeutic dosing range as 1 mg to 6 mg.

The final active ingredient in this supplement is valerian extract. This is an effective ingredient for sleep, but may be underdosed in Peptiva. A meta-study analyzed data on valerian extract and sleep from 16 clinical trials on the topic. The researchers found the supplement to be effective, but the minimum dose used in any of the trials was 225 mg daily. Peptiva contains only 50 mg.

We consider these ingredients to be more effective than the probiotics overall for sleep.

Inactive Ingredient Review

Peptiva inactive ingredients

Peptiva is naturally colored with carrot concentrate which is a much healthier option than artificial dye.

The majority of inactive ingredients in this formulation are safe and non-toxic, however there is one ingredient we typically recommend consumers avoid.

Titanium dioxide is used for its white color, but this ingredient is banned in the European Union (E.U.) for use as a food additive due to concerns over genotoxicity. This means that this additive can potentially damage DNA.

The dose of titanium dioxide in Peptiva is almost certainly very low, but it seems reasonable to avoid this ingredient entirely.

Will Peptiva Improve Sleep?

Overall we do believe that Peptiva is likely to improve sleep quality due to the effectively-dosed GABA and melatonin. However, we don’t recommend the supplement overall because of the inclusion of titanium dioxide. We also consider the probiotic blend, while harmless, to be pointless for a sleep supplement.

Sleep supplements are a relatively cheap category of dietary supplements, and we believe there are options that may be just as effective for sleep, free of questionable additive ingredients, and better-priced than Peptiva. 

We do consider Peptiva to be relatively well-formulated though, and consider the formulation to be superior to most dietary supplements we review on Illuminate Health.

Our Sleep Supplement Recommendation

We recommend Bulletproof Sleep to consumers seeking a sleep supplement.

It contains an effective dose of melatonin (3 mg), and also passionflower extract which has been shown in a clinical trial to increase total sleep time and decrease wakefulness. Most importantly, the supplement contains no questionable additive ingredients like flavoring agents.

We’re not suggesting that Bulletproof Sleep is more effective than Peptiva, but we believe it’s likely to be equally effective with a more favorable additive ingredient profile and a better price.

Peptiva currently costs $59.99 for 30 servings, which equates to a per-serving cost of $2. Bulletproof Sleep currently costs $29.95 for 30 servings, which equates to a per-serving cost of $0.99, or over 50% cheaper than Peptiva.

Interested consumers can buy Bulletproof Sleep at this link.

Peptiva Real User Reviews

Peptiva has been reviewed over 3,000 times on Amazon, and has an average review rating of 4.1 out of 5 stars. The product only scores a “C” grade on FakeSpot, which is a software tool that detects potentially fraudulent Amazon reviews. The adjusted grade that FakeSpot gives Peptiva’s sleep supplement is 2 out of 5 stars.

The top positive review from a verified purchaser comes from a user named “Linda M.” who claims the supplement is effective:

“The product does what it is advertised to do ! I was hesitant about the claims in the advertising but decided to take a chance , not much of a chance since it was free for a 15 day trial . I did not hesitate to order after the first week. You will be happy after trying!”

The top negative review from a verified purchaesr is written by a user named “vicelia k” who claims the product didn’t work for them:

“I started taking this product over a week ago, and since then I wake up every 3 hrs for no reason. I was under the impression that I would have a continuous improvement of sleeping, but do not!”

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Conclusion

Peptiva is a decently-formulated sleep supplement that we consider likely to improve sleep quality because it contains two effectively-dosed ingredients. However, we don’t recommend the supplement overall because it contains an additive ingredient we find questionable, and we consider it to be a cost-inefficient way to improve sleep.

There exist other sleep supplements like Bulletproof Sleep on the market with a lower cost-per-serving and free of questionable additive ingredients.

The majority of active ingredients in Peptiva constitute a probiotic blend, which we find to be a strange decision for a sleep supplement, given that very little clinical research exists suggesting that probiotics improve sleep quality.




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