Vyvamind Review: Do Performance Brain Supplements Work?

Vyvamind Review: Do Performance Brain Supplements Work?

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Vyvamind is a nootropic supplement used to improve focus, concentration and mental energy. The brand claims that “our research has been exhaustive” and that Vyvamind “is the only brain supplement on the market designed for performance.”

But does Vyvamind contain research-backed ingredients for improving cognition? Does it contain any questionable additive ingredients? Has the supplement been clinically tested? And how do real users rate and describe the effects of Vyvamind?

In this article we’ll answer all of these questions and more as we analyze the ingredients in Vyvamind based on medical studies to give our take on whether the supplement is likely to be effective or if it’s a waste of money.

We’ll explain if the supplement has been clinically tested and feature Vyvamind customer reviews.

Ingredient Analysis

Vyvamind ingredients

The ingredients in Vyvamind are shown above.

One immediate red flag is that no inactive ingredients are listed. What is the capsule material? Are there any fillers? This is important information for consumer safety and we hope that in the future Vyvamind publishes this information on their Supplement Facts label.

There are some research-backed ingredients in this formulation for enhancing cognitive function.

Caffeine (misspelled as “caffein” on the label) is one of the most well-studied nootropic ingredients, and was shown in a medical review published in the Journal of Alzheimer’s Disease to improve focus, cognition and memory.

The 75 milligram (mg) dose in Vyvamind, equivalent to around 80% of one cup of coffee, is relatively low based on our review of medical research, but still in the effective range.

L-theanine is an amino acid that has synergistic effects with caffeine. A 2008 clinical trial found that the combination of caffeine and l-theanine improved performance on cognitively demanding tasks.

Citicoline is clinically shown to improve memory in older adults, however as we discussed in our review of another nootropic supplement containing this ingredient called Vitaae, we cannot find any medical trials proving this ingredient effective at a dose lower than 500 mg. 

The dose in Vyvamind is only 200 mg.

L-tyrosine is another amino acid shown to improve cognition in a 2015 clinical trial, but the dose used was 2,000 mg, or more than 600% of the dose in Vyvamind.

Vitamin B6 and vitamin B12 are the two remaining active ingredients, and we cannot find any clinical evidence that these two vitamins improve cognition in individuals without deficiencies in these vitamins.

Overall, we consider Vyvamind likely to support cognition and memory given its effective dose of caffeine and l-theanine which is a potent nootropic combination. 

Assuming the inactive ingredients are safe and non-toxic, we have no issues with this formulation, but we don’t consider it a great value at over $70 per bottle.

In the next section we’ll share our concerns about some of the research cited by the brand.

Our Concerns About Vyvamind Research

The Vyvamind website has a “Research and Formulation” section that cites clinical studies on the efficacy of the active ingredients in the supplement.

However, in some cases, the research cited uses doses entirely different from that in Vyvamind.

As shown below, the Vyvamind website claims that citicoline can increase brain energy by over 13%:

Vyvamind questionable health claim 1

However, the clinical trial cited to back this claim used daily doses of 500 mg or 2,000 mg of citicoline, which is 250% and 1,000% higher than the dose per-serving in Vyvamind.

The Vyvamind website claims that tyrosine can reduce reaction times and minimize stress:

Vyvamind questionable health claim 2

However, the medical review cited to back this claim does not prove these effects at the dose in Vyvamind.

The Vyvamind website claims that vitamins B6 and B12 can support brain health:

Vyvamind questionable health claim 3

However, the clinical trial cited to back this claim only studied the effects of vitamin B6 supplementation (not vitamin B12 supplementation), and the daily dose used was 20 mg, or 800% of the amount in Vyvamind.

We urge Vyvamind to either update their medical citations or remove specific health claims from their website which are currently backed by research that is not dose-matched.

But how do real users rate and describe the effects of Vyvamind? We’ll review in the next section.

Real People Try Vyvamind

A YouTube creator named “Mr RAGE” who claims to have ADHD complains that Vyvamind is a waste of money:

A TikTok creator named Rika Shanay shared her experience using Vyvamind:

@rikashanay A quick review for Vyvamind. Neurostimulant + Focus aid supplement. Please do your own research! B6 & B12 included. #supplements #memory #vyvamind #focus #itsachickensalad #yallbettercomeuphereandgetoneofthese ♬ original sound - Rika Shanay

Does Vyvamind Cause Side Effects?

Vyvamind does not appear to be clinically tested, so it’s challenging to say for certain whether or not the supplement will cause side effects.

However, we can make an educated guess based on its active ingredients.

We do not consider Vyvamind likely to cause side effects. All of its active ingredients are well-studied, and none are included at a dangerously high dose in our opinion.

Even caffeine, which is a stimulant, is included at a dose less than the equivalent of one cup of coffee, so it should be acceptable for even caffeine-sensitive individuals. The l-theanine has a calming effect which should balance caffeine’s stimulatory effects.

Our main concern in regard to side effects is the lack of inactive ingredient information. We consider the risk of side effects to be higher for any supplement without a clearly published full set of ingredients, because without this information consumers cannot make informed decisions and avoid ingredients they may be allergic or sensitive to.

We do not recommend using any supplement without clearly published active and inactive ingredients.

The brand’s website currently states that taking the recommended dose is unlikely to cause side effects, while taking more than the recommended dose “drastically increases the risks of side effects.”

Where to Buy Vyvamind?

At the time of publishing this article, Vyvamind only appears to be for sale on the manufacturer’s official website, which can be accessed here (we do not endorse this product nor are we affiliated with this brand).

Vyvamind does not appear to be sold on large third-party internet retailers like Amazon or Walmart, and purchasing directly from the brand may reduce the risk of counterfeit products.

There is no mention of authorized retailers or distributors that we could find on the Vyvamind website, so for consumers intent on purchasing this supplement, we recommend doing so from the brand directly.

Our Clean Nootropic Picks

Mind Lab Pro by Performance Lab is our top premium nootropic pick.

This is the first Illuminate Labs Certified supplement, and has been shown to be effective for short-term cognitive improvements in two clinical trials published in peer-reviewed journals.

Performance Lab MCT Oil is our top food-based nootropic pick.

MCT oil is derived from coconut oil, and improved memory recall by 20% in adults in a 2022 meta-study.

Illuminate Labs Ginkgo Biloba Extract is our top herbal nootropic pick.

medical review published in the Psychopharmacology journal found that ginkgo biloba supplementation improved attention and cognitive performance in healthy, young adults.

Pros and Cons of Vyvamind

Here are the pros and cons of Vyvamind in our opinion:


  • Several research-backed active ingredients
  • Should support cognition
  • Should support memory
  • Safe active ingredients
  • Unlikely to cause side effects


  • Brand makes questionable research claims
  • Inactive ingredients not published on Supplement Facts label
  • Some active ingredients are underdosed in our opinion
  • Expensive
  • Doesn’t appear clinically tested
Stay up-to-date on our research reviews


Vyvamind contains a number of research-backed active ingredients, and we do consider the supplement likely to support cognition, memory and focus.

That being said, the only active ingredients in this formulation that we consider effectively dosed, based on a review of medical research, are caffeine and l-theanine. It’s much cheaper to get caffeine and l-theanine elsewhere.

The brand fails to publish inactive ingredients on the Supplement Facts label at the time of publishing this article, which is a concern that we hope the brand either clarifies or rectifies, given that this potentially affects consumer safety.

The Vyvamind website has a research section, but some of the research cited to back ingredient efficacy includes vastly higher doses than the ingredient doses actually in Vyvamind.

For consumers intent on purchasing this supplement, we recommend purchasing from the brand website directly, since there don’t appear to be any authorized distributors or third-party sellers on sites like Amazon.